2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

In enzymology, a 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase () is an enzyme that catalysis, catalyzes the chemical reaction

:2-dehydro-3-deoxy-D-gluconate + NAD⁺ $\rightleftharpoons$ (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H⁺

Thus, the two substrate (biochemistry), substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconate and nicotinamide adenine dinucleotide, NAD⁺, whereas its 3 product (chemistry), products are (4S)-4,6-dihydroxy-2,5-dioxohexanoate, nicotinamide adenine dinucleotide, NADH, and hydrogen ion, H⁺.

This enzyme participates in pentose and glucuronate interconversions.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The List of enzymes, systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NAD⁺ 5-oxidoreductase. Other names in common use include 2-keto-3-deoxygluconate 5-dehydrogenase, 2-keto-3-deoxy-D-gluconate dehydrogenase, 2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide, (phosphate)) dehydrogenase, 2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic, and acid) dehydrogenase.

References

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EC 1.1.1
NADH-dependent enzymes
Enzymes of unknown structure

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