2-Tetralone is an
organic chemical compound with the molecular formula C
10H
10O. This colourless oil is an intermediate in
organic synthesis
Organic synthesis is a branch of chemical synthesis concerned with the construction of organic compounds. Organic compounds are molecules consisting of combinations of covalently-linked hydrogen, carbon, oxygen, and nitrogen atoms. Within the gen ...
. It is a
ketone
In organic chemistry, a ketone is an organic compound with the structure , where R and R' can be a variety of carbon-containing substituents. Ketones contain a carbonyl group (a carbon-oxygen double bond C=O). The simplest ketone is acetone ( ...
derivative of
tetralin, a
hydrogenated derivative of
naphthalene
Naphthalene is an organic compound with formula . It is the simplest polycyclic aromatic hydrocarbon, and is a white Crystal, crystalline solid with a characteristic odor that is detectable at concentrations as low as 0.08 Parts-per notation ...
.
History and synthesis
The compound was first obtained by
Eugen Bamberger and Wilhelm Lodter in 1893 by
dehydrohalogenation of 3-chloro-2-tetralol with hot alkali.
2-Tetralone may be prepared by reductive cleavage of 2-naphthyl ethers.
Applications
2-Tetralone is an intermediate in the synthesis of a variety of pharmaceutical drugs including
L-687,384,
nepinalone,
napamezole,
, and
trioxifene.
See also
*
1-Tetralone
References
{{DEFAULTSORT:Tetralone, 2-
Tetralones