2-''C''-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (MEcPP synthase, IspF, EC 4.6.1.12) is a

zinc Zinc is a chemical element; it has symbol Zn and atomic number 30. It is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in group 12 (IIB) of the periodic tabl ...

-dependent

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

and a member of the YgbB N terminal protein domain, which participates in the MEP pathway (non-mevalonate pathway) of

isoprenoid The terpenoids, also known as isoprenoids, are a class of naturally occurring organic chemicals derived from the 5-carbon compound isoprene and its derivatives called terpenes, diterpenes, etc. While sometimes used interchangeably with "terpene ...

precursor biosynthesis. It

catalyzes Catalysis () is the increase in rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quick ...

the following reaction: :4-diphosphocytidyl-2-''C''-methyl-D)erythritol 2-phosphate

\rightleftharpoons

2-''C''-methyl-D-erythritol 2,4-cyclodiphosphate + CMP The enzyme is considered a phosphorus-oxygen lyase. The

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ...

of this enzyme class is 2-phospho-4-(cytidine 5′-diphospho)-2-''C''-methyl-D-D-erythritol CMP-lyase (cyclizing; 2-''C''-methyl-D-erythritol 2,4-cyclodiphosphate-forming). Other names in common use include IspF, YgbB and MEcPP synthase.

Structural studies

As of late 2007, 20

structures A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ...

have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , , and .

References

EC 4.6.1 Enzymes of known structure {{lyase-stub