2,5-Dimethoxy-4-ethoxyamphetamine (MEM) is a
psychedelic drug
A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhal ...
of the
phenethylamine and
amphetamine
Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used ...
chemical classes. It was first
synthesized by
Alexander Shulgin.
In his book ''
PiHKAL'', he lists the active dose range as 20–50 mg, and the duration as 10–14 hours.
According to Shulgin, MEM produces color enhancement, visual phenomena, and pattern movement, among other effects.
MEM possesses
affinity (K
i) for the
5-HT2A (3,948 nM),
5-HT2B (64.5 nM),
5-HT7 (7,156 nM), and
σ1 (5,077 nM)
receptors. It behaves as a
partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonist ...
at the 5-HT
2A receptor.
MEM is relatively
selective for these sites and displays low/negligible (> 10,000 nM) affinity for a wide array of other targets.
See also
*
2,5-Dimethoxy-4-substituted amphetamine
4-Substituted-2,5-dimethoxyamphetamines (DO''x'') is a chemical class of substituted amphetamine derivatives featuring methoxy groups at the 2- and 5- positions of the phenyl ring, and a substituent such as alkyl or halogen at the 4- position of ...
s
References
External links
MEM entry in ''PiHKAL''MEM entry in PiHKAL • info
5-HT2B agonists
Substituted amphetamines
2,5-Dimethoxyphenethylamines
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