2,2'-Azobis(2-amidinopropane) dihydrochloride (abbreviated AAPH or AMPA) is a chemical compound used to study the chemistry of the
oxidation
Redox ( , , reduction–oxidation or oxidation–reduction) is a type of chemical reaction in which the oxidation states of the reactants change. Oxidation is the loss of electrons or an increase in the oxidation state, while reduction is ...
of
drug
A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via insufflation (medicine), inhalation, drug i ...
s.
It is a
free radical
A daughter category of ''Ageing'', this category deals only with the biological aspects of ageing.
Ageing
Biogerontology
Biological processes
Causes of death
Cellular processes
Gerontology
Life extension
Metabolic disorders
Metabolism
...
-generating
azo compound
Azo compounds are organic compounds bearing the functional group diazenyl (, in which R and R′ can be either aryl or alkyl groups).
IUPAC defines azo compounds as: "Derivatives of diazene (diimide), , wherein both hydrogens are substituted ...
. It is gaining prominence as a model oxidant in
small molecule
In molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm. Many drugs are small molecules; ...
and
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
therapeutics for its ability to initiate oxidation reactions via both nucleophilic and free radical mechanisms.
2,2′-azobis (2-amidinopropane) dihydrochloride has been used in experiments on
linoleic acid subjected to induced oxidation with different combinations of binary mixtures of
natural phenolics. The experiments show that some binary mixtures can lead to a
synergetic antioxidant effect while other mixtures lead to an
antagonistic effect.
[Antioxidant activity of phenolic compounds in 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced oxidation: Synergistic and antagonistic effects. M. N. Peyrat-Maillard, M. E. Cuvelier and C. Berset, Journal of the American Oil Chemists' Society, 2003, Volume 80, Number 10, pages 1007-1012, ]
References
{{DEFAULTSORT:Azobis(2-amidinopropane) dihydrochloride, 2,2'-
Azo compounds
Amidines
Hydrochlorides