14-Methoxydihydromorphinone is a
semi-synthetic
Semisynthesis, or partial chemical synthesis, is a type of chemical synthesis that uses chemical compounds isolated from natural sources (such as microbial cell cultures or plant material) as the starting materials to produce novel compounds wit ...
opioid
Opioids are a class of Drug, drugs that derive from, or mimic, natural substances found in the Papaver somniferum, opium poppy plant. Opioids work on opioid receptors in the brain and other organs to produce a variety of morphine-like effects, ...
related to
14-methoxymetopon (14-MM), an opioid with a K
i of 0.15 nM, and
14-O-methyloxymorphone (14-OMO) with a K
i of 0.10 nM. By contrast,
oxymorphone
Oxymorphone (sold under the brand names Numorphan and Opana among others) is a highly potent opioid analgesic indicated for treatment of severe pain. Pain relief after injection begins after about 5–10 minutes; after oral administration it ...
has a K
i of 0.97 nM and
morphine
Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (''Papaver somniferum''). It is mainly used as an analgesic (pain medication). There are ...
one of 6.55 nM (all at
mu receptors). This suggests that both 14-OMO and 14-MM have a higher mu/kappa selectivity than oxymorphone.
See also
*
Metopon
Metopon (5-methylhydromorphone, CAS number 124-92-5) is an opioid analogue that is a methylated derivative of hydromorphone which was invented in 1929 as an analgesic
An analgesic drug, also called simply an analgesic, antalgic, pain reliev ...
References
4,5-Epoxymorphinans
Mu-opioid receptor agonists
Semisynthetic opioids
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