1-Hydroxyphenanthrene is a
phenanthrol and a human metabolite of
phenanthrene
Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) with formula C14H10, consisting of three fused benzene rings. It is a colorless, crystal-like solid, but can also appear yellow. Phenanthrene is used to make dyes, plastics, pesticides, expl ...
that can be detected in urine of persons exposed to PAHs.
It can also be used as a marker for PAH pollution measured in marine fish bile.
The model fungus ''
Cunninghamella elegans
''Cunninghamella elegans'' is a species of fungus in the genus ''Cunninghamella'' found in soil.
It can be grown in Raymond Sabouraud, Sabouraud dextrose broth, a liquid medium used for cultivation of yeasts and molds from liquid which are norma ...
'' produces, in the case of the biodegradation of phenanthrene, a
glucoside
A glucoside is a glycoside that is chemically derived from glucose. Glucosides are common in plants, but rare in animals. Glucose is produced when a glucoside is hydrolysed by purely chemical means, or decomposed by fermentation or enzymes.
Th ...
conjugate of 1-hydroxyphenanthrene (
phenanthrene 1-O-beta-glucose).
Relationship with smoking
Highly significant differences and dose-response relationships with regard to cigarettes smoked per day were found for
2-,
3- and
4-hydroxyphenanthrene and
1-hydroxypyrene, but not for 1-hydroxyphenanthrene.
[Urinary monohydroxylated phenanthrenes and hydroxypyrene – the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism. Heudorf U and Angerer J, International Archives of Occupational and Environmental Health, April 2001, Volume 74, Issue 3, pages 177-183, ]
References
External links
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{{DEFAULTSORT:Hydroxyphenanthrene, 1-
Phenanthrenoids
Phenolic human metabolites