Integrin beta-3 (β3) or CD61 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''ITGB3''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. CD61 is a

cluster of differentiation The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophe ...

found on

thrombocyte Platelets or thrombocytes () are a part of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping to form a blood clot. Platelets have no cell nucleus; they are fragments of cytop ...

Structure and function

The ITGB3 protein product is the integrin beta chain beta 3.

Integrins Integrins are transmembrane receptors that help cell–cell and cell– extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, ...

are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.

Role in endometriosis

Defectively expressed β3 integrin subunit has been correlated with presence of

endometriosis Endometriosis is a disease in which Tissue (biology), tissue similar to the endometrium, the lining of the uterus, grows in other places in the body, outside the uterus. It occurs in women and a limited number of other female mammals. Endomet ...

, and has been suggested as a putative marker of this condition.

Interactions

CD61 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...

with

PTK2 PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the ''PTK2'' gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to ...

ITGB3BP Centromere protein R is a protein that in humans is encoded by the ''ITGB3BP'' gene. Interactions ITGB3BP has been shown to interact with: * CD61, * Cyclin A2, * NFKB1 Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is enco ...

TLN1 Talin-1 is a protein that in humans is encoded by the ''TLN1'' gene. Talin-1 is ubiquitously expressed, and is localized to costamere structures in cardiac muscle, cardiac and skeletal muscle cells, and to focal adhesions in smooth muscle and non ...

and

CIB1 Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the ''CIB1'' gene and is located in Chromosome 15. The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this ...

References

External links

*
ITGB3
Info with links in th
Cell Migration Gateway
* Integrins {{gene-17-stub

Structure and function

Role in endometriosis

Interactions

See also

References

Further reading

External links