(Histone-H3)-lysine-36 demethylase (, ''JHDM1A'', ''JmjC domain-containing histone demethylase 1A'', ''H3-K36-specific demethylase'', ''histone-lysine (H3-K36) demethylase'', ''histone demethylase'', ''protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase'') is an

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

with

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ...

''protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase''. This enzyme catalyses the following

chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...

: protein N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O₂

\rightleftharpoons

protein L-lysine + 2

succinate Succinic acid () is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2. In living organisms, succinic acid takes the form of an anion, succinate, which has multiple biological roles as a metabolic intermediate being converted into Fuma ...

+ 2

formaldehyde Formaldehyde ( , ) (systematic name methanal) is an organic compound with the chemical formula and structure , more precisely . The compound is a pungent, colourless gas that polymerises spontaneously into paraformaldehyde. It is stored as ...

+ 2 CO₂ (overall reaction) :(1a) protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O₂

\rightleftharpoons

protein N6-methyl-L-lysine + succinate + formaldehyde + CO₂ :(1b) protein N6-methyl-L-lysine + 2-oxoglutarate + O2

\rightleftharpoons

protein L-lysine + succinate + formaldehyde + CO₂ (Histone-H3)-lysine-36 demethylase contains

iron Iron is a chemical element; it has symbol Fe () and atomic number 26. It is a metal that belongs to the first transition series and group 8 of the periodic table. It is, by mass, the most common element on Earth, forming much of Earth's o ...

(II).

References

External links

* {{DEFAULTSORT:Histone-H3)-lysine-36 demethylase EC 1.14.11 Epigenetics Post-translational modification