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Vasopressin V1A Receptor
Vasopressin receptor 1A (V1AR), or arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major Receptor (biochemistry), receptor types for vasopressin (Arginine vasopressin receptor 1B, AVPR1B and Arginine vasopressin receptor 2, AVPR2 being the others), and is present throughout the brain, as well as in the periphery in the liver, kidney, and Circulatory system, vasculature. AVPR1A is also known as: * V1a vasopressin receptor * antidiuretic hormone receptor 1A * SCCL vasopressin subtype 1a receptor * V1-vascular vasopressin receptor AVPR1A * vascular/hepatic-type arginine vasopressin receptor Structure and function Human AVPR1A cDNA is 1472 bp long and encodes a 418 amino-acid long polypeptide which shares 72%, 36%, 37%, and 45% sequence identity with rat AVPR1A, human AVPR2, rat AVPR2, and human oxytocin receptor (OXTR), respectively. AVPR1A is a G-protein coupled receptor (GPCR) with 7 Transmembrane domain, transmembrane domains that couples to Gq a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Antihypotensive Agent
An antihypotensive, also known as a vasopressor, is an agent that raises blood pressure by constricting blood vessels, thereby increasing systemic vascular resistance. This is different from inotropes which increase the force of cardiac contraction. Some substances do both (e.g. dopamine, dobutamine). If low blood pressure is due to blood loss, then preparations increasing volume of blood circulation—plasma-substituting solutions such as colloid and crystalloid solutions (salt solutions)—will raise the blood pressure without any direct vasopressor activity. Packed red blood cells, plasma or whole blood should not be used solely for volume expansion or to increase oncotic pressure of circulating blood. Blood products should only be used if reduced oxygen carrying capacity or coagulopathy is present. Other causes of either absolute (dehydration, loss of plasma via wound/burns) or relative ( third space losses) vascular volume depletion also respond, although blood products a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |