|
Uterine Papillary Serous Carcinoma
Uterine serous carcinoma is a malignant form of serous tumor that originates in the uterus. It is an uncommon form of endometrial cancer that typically arises in postmenopausal women. It is typically diagnosed on endometrial biopsy, prompted by post-menopausal bleeding. Unlike the more common low-grade endometrioid endometrial adenocarcinoma, uterine serous carcinoma does not develop from endometrial hyperplasia and is not hormone-sensitive. It arises in the setting of endometrial atrophy and is classified as a type II endometrial cancer. Cause Initially there is a precursor lesion called serous endometrial intraepithelial carcinoma. Mutation is found in TP53 gene which is a tumor suppressor gene even in precursor lesion suggesting early involvement of this gene. Also many missense mutation and mutation in PI3K and PP2A genes are involved which also contribute to this tumor. Diagnosis The lesion is found in patients who present typically with abnormal or postmenopausal bleed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histology H&E
Histology, also known as microscopic anatomy or microanatomy, is the branch of biology that studies the microscopic anatomy of biological tissue (biology), tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures visible without a microscope. Although one may divide microscopic anatomy into ''organology'', the study of organs, ''histology'', the study of tissues, and ''cytology'', the study of cell (biology), cells, modern usage places all of these topics under the field of histology. In medicine, histopathology is the branch of histology that includes the microscopic identification and study of diseased tissue. In the field of paleontology, the term paleohistology refers to the histology of fossil organisms. Biological tissues Animal tissue classification There are four basic types of animal tissues: muscle tissue, nervous tissue, connective tissue, and epithelial tissue. All animal tissues are considered to be subtypes of these ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cilia
The cilium (: cilia; ; in Medieval Latin and in anatomy, ''cilium'') is a short hair-like membrane protrusion from many types of eukaryotic cell. (Cilia are absent in bacteria and archaea.) The cilium has the shape of a slender threadlike projection that extends from the surface of the much larger cell body. Eukaryotic flagella found on sperm cells and many protozoans have a similar structure to motile cilia that enables swimming through liquids; they are longer than cilia and have a different undulating motion. There are two major classes of cilia: ''motile'' and ''non-motile'' cilia, each with two subtypes, giving four types in all. A cell will typically have one primary cilium or many motile cilia. The structure of the cilium core, called the axoneme, determines the cilium class. Most motile cilia have a central pair of single microtubules surrounded by nine pairs of double microtubules called a 9+2 axoneme. Most non-motile cilia have a 9+0 axoneme that lacks the central pai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HER2/neu
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ''ERBB2'' gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 ( cluster of differentiation 340). HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Platinum
Platinum is a chemical element; it has Symbol (chemistry), symbol Pt and atomic number 78. It is a density, dense, malleable, ductility, ductile, highly unreactive, precious metal, precious, silverish-white transition metal. Its name originates from Spanish language, Spanish , a diminutive of "silver". Platinum is a member of the platinum group of elements and group 10 element, group 10 of the periodic table of elements. It has six naturally occurring isotopes. It is one of the Abundance of elements in Earth's crust, rarer elements in Earth's crust, with an average abundance of approximately 5 microgram, μg/kg, making platinum about 30 times rarer than gold. It occurs in some nickel and copper ores along with some Native element mineral, native deposits, with 90% of current production from deposits across Russia's Ural Mountains, Colombia, the Sudbury Basin, Sudbury basin of Canada, and a large reserve in South Africa. Because of its scarcity in Earth's crust, only a f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiation Therapy
Radiation therapy or radiotherapy (RT, RTx, or XRT) is a therapy, treatment using ionizing radiation, generally provided as part of treatment of cancer, cancer therapy to either kill or control the growth of malignancy, malignant cell (biology), cells. It is normally delivered by a linear particle accelerator. Radiation therapy may be cure, curative in a number of types of cancer if they are localized to one area of the body, and have not metastasis, spread to other parts. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist. Radiation therapy is commonly applied to the canc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymphatic System
The lymphatic system, or lymphoid system, is an organ system in vertebrates that is part of the immune system and complementary to the circulatory system. It consists of a large network of lymphatic vessels, lymph nodes, lymphoid organs, lymphatic tissue and lymph. Lymph is a clear fluid carried by the lymphatic vessels back to the heart for re-circulation. The Latin word for lymph, , refers to the deity of fresh water, "Lympha". Unlike the circulatory system that is a closed system, the lymphatic system is open. The human circulatory system processes an average of 20 litres of blood per day through Starling equation, capillary filtration, which removes blood plasma, plasma from the blood. Roughly 17 litres of the filtered blood is reabsorbed directly into the blood vessels, while the remaining three litres are left in the interstitial fluid. One of the main functions of the lymphatic system is to provide an accessory return route to the blood for the surplus three litres. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymphadenectomy
Lymphadenectomy, or lymph node dissection, is the surgical removal of one or more groups of lymph nodes. It is almost always performed as part of the surgical management of cancer. In a regional lymph node dissection, some of the lymph nodes in the tumor area are removed; in a radical lymph node dissection, most or all of the lymph nodes in the tumor area are removed. Indications Lymphadenectomies are usually done because many types of cancer have a marked tendency to produce lymph node metastasis early in their natural histories. This is particularly true of melanoma, head and neck cancer, differentiated thyroid cancer, breast cancer, lung cancer, gastric cancer, and colorectal cancer. Famed British surgeon Berkeley Moynihan once remarked that "the surgery of cancer is not the surgery of organs; it is the surgery of the lymphatic system." The better-known examples of lymphadenectomy are '' axillary lymph node dissection'' for breast cancer; ''radical neck dissection'' for h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salpingo-oophorectomy
In medicine, salpingo-oophorectomy is the removal of an ovary and its fallopian tube. This procedure is most frequently associated with prophylactic surgery in response to the discovery of a BRCA mutation, particularly those of the normally tumor suppressing ''BRCA1'' gene (or, with a statistically lower negative impact, those of the tumour suppressing ''BRCA2'' gene), which can increase the risk of a woman developing ovarian cancer to as high as 65% (as high as 25% for a mutated ''BRCA2'' gene). See also * List of surgeries by type * Oophorectomy Oophorectomy (; from Greek , , 'egg-bearing' and , , 'a cutting out of'), historically also called ''ovariotomy'', is the surgical removal of an ovary or ovaries. The surgery is also called ovariectomy, but this term is mostly used in reference ... References Gynecological surgery Surgical removal procedures {{Surgery-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hysterectomy
Hysterectomy is the surgical removal of the uterus and cervix. Supracervical hysterectomy refers to removal of the uterus while the cervix is spared. These procedures may also involve removal of the ovaries (oophorectomy), fallopian tubes ( salpingectomy), and other surrounding structures. The term “partial” or “total” hysterectomy are lay-terms that incorrectly describe the addition or omission of oophorectomy at the time of hysterectomy. These procedures are usually performed by a gynecologist. Removal of the uterus is a form of sterilization, rendering the patient unable to bear children (as does removal of ovaries and fallopian tubes) and has surgical risks as well as long-term effects, so the surgery is normally recommended only when other treatment options are not available or have failed. It is the second most commonly performed gynecological surgical procedure, after cesarean section, in the United States. Nearly 68 percent were performed for conditions such as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gynecologic Oncology (journal)
''Gynecologic Oncology'' is a peer-reviewed medical journal covering all aspects of gynecologic oncology. The journal covers investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest. It is published by Elsevier and is the official journal of the Society of Gynecologic Oncology. Abstracting and indexing The journal is abstracted and indexed in Current Contents/Clinical Medicine, Index Medicus, Science Citation Index, and Scopus Scopus is a scientific abstract and citation database, launched by the academic publisher Elsevier as a competitor to older Web of Science in 2004. The ensuing competition between the two databases has been characterized as "intense" and is c .... References External links * Elsevier academic journals Monthly journals Oncology journals Academic journals established in 1972 English-language journals Obstetrics and gynaecology jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myometrium
The myometrium is the middle layer of the uterine wall, consisting mainly of uterine smooth muscle cells (also called uterine myocytes) but also of supporting stromal and vascular tissue. Its main function is to induce uterine contractions. Structure The myometrium is located between the endometrium (the inner layer of the uterine wall) and the serosa or perimetrium (the outer uterine layer). The myometrium can be divided into three layers: * The inner one-third thickness is termed the ''junctional'' or ''sub-endometrial'' layer. In most mammals it is characterized by fibers oriented in a circular way. Humans, having a single uterus form the fusion of two Müllerian ducts, have the fibers forming two cones. Mice have an unfused uterus, so the arrangement is simply circular. * The middle layer occurs in both mice and humans. In mice it is a hard-to-spot mesh-like structure that probably helps coordinate the forces from the inner and outer layers. In humans there is also a mesh-li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
