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Trypanocide
A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites. Examples include: * Aminoquinuride * benzonidazole * blasticidin S * DAPI * diminazene * diminazene aceturate * eflornithine * ethidium * isometamidium chloride * lonidamine * melaminylthioarsenate * melarsoprol * nifurtimox * pentamidine * posaconazole * puromycin * quinapyramine * salicylhydroxamic acid * suramin * tetraphenylporphine sulfonate Resistance , 17 or 18 African countries had confirmed resistant parasite populations, and that was up to 21. Multiply resistant populations are an increasing problem in the Adamawa Region of Cameroon and south east Mali. The Gibe River Valley in southwest Ethiopia showed universal resistance (in '' T. congolense'' isolated from Boran cattle) between July 1989 and February 1993. This likely indicates a permanent loss of function in this area for the tested trypanocides, diminazene aceturate, isometamidium chloride, and homidium chloride. See also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanocide Resistance
A trypanocidal agent is an antiprotozoal agent that acts upon Trypanosoma, trypanosome parasites. Examples include: * Aminoquinuride * benzonidazole * blasticidin S * DAPI * diminazene * diminazene aceturate * eflornithine * ethidium * isometamidium chloride * lonidamine * melaminylthioarsenate * melarsoprol * nifurtimox * pentamidine * posaconazole * puromycin * quinapyramine * salicylhydroxamic acid * suramin * tetraphenylporphine sulfonate Resistance , 17 or 18 African countries had confirmed trypanocide resistance, resistant parasite populations, and that was up to 21. Multiple drug resistance, Multiply resistant populations are an increasing problem in the Adamawa Region of Cameroon and south east Mali. The Gibe River Valley in southwest Ethiopia showed universal resistance (in ''Trypanosoma congolense, T. congolense'' isolated from Boran cattle) between July 1989 and February 1993. This likely indicates a permanent loss of function in this area for the tested trypanocides, di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanosoma Congolense
''Trypanosoma congolense'' is a species of trypanosomes and is the major pathogen responsible for the disease nagana in cattle and other animals including sheep, pigs, goats, horses and camels, dogs, as well as laboratory mice. It is the most common cause of nagana in east Africa, but is also a major cause of nagana in west Africa. This parasite is spread by tsetse flies. In its mammalian host, ''Trypanosoma congolense'' only lives in blood vessels, and causes in particular anaemia. , USAHA gray book, 6th ed. (1998). Infection process ''T. congolense'' causes . Nok ''et al.'', 2003 find ''T. congolense'' to alter the surf ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suramin
Suramin is a medication used to treat African sleeping sickness and river blindness. It is the treatment of choice for sleeping sickness without central nervous system involvement. It is given by injection into a vein. Suramin causes a fair number of side effects. Common side effects include nausea, vomiting, diarrhea, headache, skin tingling, and weakness. Sore palms of the hands and soles of the feet, trouble seeing, fever, and abdominal pain may also occur. Severe side effects may include low blood pressure, decreased level of consciousness, kidney problems, and low blood cell levels. It is unclear if it is safe when breastfeeding. Suramin was made at least as early as 1916. It is on the World Health Organization's List of Essential Medicines. In the United States it can be acquired from the Centers for Disease Control (CDC). In regions of the world where the disease is common suramin is provided for free by the World Health Organization (WHO). Medical uses Suramin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Posaconazole
Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication. It was approved for medical use in the European Union in October 2005, and in the United States in September 2006. It is available as a generic medication. Medical uses Posaconazole is used to treat invasive ''Aspergillus'' and '' Candida'' infections. It is also used for the treatment of oropharyngeal candidiasis (OPC), including OPC refractory to other drugs such as itraconazole and fluconazole. Clinical evidence of efficacy in treatment of invasive disease caused by ''Fusarium'' species ( fusariosis) is limited. It appears to be helpful in a mouse model of naegleriasis and kills ''Acanthamoeba castellanii'' cysts ''in vitro''. It has been used to treat mucormycosis (black fungus disease) caused by ''Rhizopus'' mold. Pharmacology Pharmacodynamics Posaconazole works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethiopia
Ethiopia, officially the Federal Democratic Republic of Ethiopia, is a landlocked country located in the Horn of Africa region of East Africa. It shares borders with Eritrea to the north, Djibouti to the northeast, Somalia to the east, Kenya to the south, South Sudan to the west, and Sudan to the northwest. Ethiopia covers a land area of . , it has around 128 million inhabitants, making it the List of countries and dependencies by population, thirteenth-most populous country in the world, the List of African countries by population, second-most populous in Africa after Nigeria, and the most populous landlocked country on Earth. The national capital and largest city, Addis Ababa, lies several kilometres west of the East African Rift that splits the country into the African Plate, African and Somali Plate, Somali tectonic plates. Early modern human, Anatomically modern humans emerged from modern-day Ethiopia and set out for the Near East and elsewhere in the Middle Paleolithi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gibe River
The Gibe River (also Great Gibe River) is by far the largest tributary of the Omo River in southwestern Ethiopia and flows generally south-southeast. The confluence of the Gibe River with the smaller Wabe River forms the Omo River. The whole drainage basin is sometimes referred to as the ''Omo-Gibe River Basin'' with the Gibe and the Omo draining the (respectively) upper and lower reaches. In common with most of Ethiopia's rivers, the Gibe is not navigable. Overview The Gibe rises at an elevation of more than 2,000 m north of Bila town, west of the Chomen swamp from Gudeya Bila woreda, which is located in the East Welega Zone, Oromia Region. The river then flows generally to the southeast towards its confluence with the Wabe River. Its tributaries include the Amara, Alanga, and Gilgel Gibe rivers. The southern drainage area of the Gibe includes the Gibe region, site of a number of historic kingdoms of the Oromo and the Sidama people. The Gibe River terminates at an el ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mali
Mali, officially the Republic of Mali, is a landlocked country in West Africa. It is the List of African countries by area, eighth-largest country in Africa, with an area of over . The country is bordered to the north by Algeria, to the east by Niger, to the northwest by Mauritania, to the south by Burkina Faso and Ivory Coast, and to the west by Guinea and Senegal. The population of Mali is about 23.29 million, 47.19% of which are estimated to be under the age of 15 in 2024. Its Capital city, capital and largest city is Bamako. The country has 13 official languages, of which Bambara language, Bambara is the most commonly spoken. The sovereign state's northern borders reach deep into the middle of the Sahara, Sahara Desert. The country's southern part, where the majority of inhabitants live, is in the Sudanian savanna and has the Niger River, Niger and Senegal River, Senegal rivers running through it. The country's economy centres on agriculture and mining with its most promine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cameroon
Cameroon, officially the Republic of Cameroon, is a country in Central Africa. It shares boundaries with Nigeria to the west and north, Chad to the northeast, the Central African Republic to the east, and Equatorial Guinea, Gabon, and the Republic of the Congo to the south. Its coastline lies on the Bight of Biafra, part of the Gulf of Guinea, and the Atlantic Ocean. Due to its strategic position at the crossroads between West Africa and Central Africa, it has been categorized as being in both camps. Cameroon's population of nearly 31 million people speak 250 native languages, in addition to the national tongues of English and French, or both. Early inhabitants of the territory included the Sao civilisation around Lake Chad and the Baka people (Cameroon and Gabon), Baka hunter-gatherers in the southeastern rainforest. Portuguese discoveries, Portuguese explorers reached the coast in the 15th century and named the area ''Rio dos Camarões'' (''Shrimp River''), which became ''C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adamawa Region
The Adamawa Region () is a constituent region of the Cameroon, Republic of Cameroon. It borders the Centre Region (Cameroon), Centre and East Region (Cameroon), East regions to the south, the Northwest Region (Cameroon), Northwest and West Region (Cameroon), West regions to the southwest, Nigeria to the west, the Central African Republic (CAR) to the east, and the North Region (Cameroon), North Region to the north. This mountainous area forms the barrier between Cameroon's forested south and savanna north. At almost 64,000 km2 in land area, the Adamawa is the third largest of regions of Cameroon, Cameroon's ten regions. The land is rugged and sparsely populated, however, as most is devoted to the rearing of cattle. The Islam, Muslim Fula people, Fulbe (Fulani) form the major ethnic group, though Tikar, Gbaya people, Gbaya, and other peoples are present in lesser numbers. History Early population movements The Adamawa's oldest populations were various Paleo-Sudanese peo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multiple Drug Resistance
Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to at least one antimicrobial drug in three or more antimicrobial categories. Antimicrobial categories are classifications of antimicrobial agents based on their mode of action and specific to target organisms. The MDR types most threatening to public health are MDR bacteria that resist multiple antibiotics; other types include MDR viruses, parasites (resistant to multiple antifungal, antiviral, and antiparasitic drugs of a wide chemical variety). Recognizing different degrees of MDR in bacteria, the terms ''extensively drug-resistant'' (''XDR'') and ''pandrug-resistant'' (''PDR'') have been introduced. ''Extensively drug-resistant (XDR)'' is the non-susceptibility of one bacteria species to all antimicrobial agents except in two or less antimicrobial categories. Within XDR, ''pandrug-resistant (PDR)'' is the non-susceptibility of bacteria to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Africa
Africa is the world's second-largest and second-most populous continent after Asia. At about 30.3 million km2 (11.7 million square miles) including adjacent islands, it covers 20% of Earth's land area and 6% of its total surface area.Sayre, April Pulley (1999), ''Africa'', Twenty-First Century Books. . With nearly billion people as of , it accounts for about of the world's human population. Demographics of Africa, Africa's population is the youngest among all the continents; the median age in 2012 was 19.7, when the worldwide median age was 30.4. Based on 2024 projections, Africa's population will exceed 3.8 billion people by 2100. Africa is the least wealthy inhabited continent per capita and second-least wealthy by total wealth, ahead of Oceania. Scholars have attributed this to different factors including Geography of Africa, geography, Climate of Africa, climate, corruption, Scramble for Africa, colonialism, the Cold War, and neocolonialism. Despite this lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
