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Thujone
Thujone () is a ketone and a terpene, monoterpene that occurs predominantly in two diastereomeric (epimeric) forms: (−)-α-thujone and (+)-β-thujone. Though it is best known as a chemical compound in the spirit absinthe, it is only present in trace amounts and is unlikely to be responsible for the spirit's purported stimulant and psychoactive effects. Thujone acts on the GABAA receptor, GABAA receptor as an antagonist. As a competitive antagonist of GABAA receptor, thujone alone is considered to be convulsant, though by interfering with the inhibitory transmitter GABA, it may convey stimulating, mood-elevating effects at low doses. It is also found in perfumery as a component of several essential oils. In addition to the naturally occurring (−)-α-thujone and (+)-β-thujone, two other forms are possible: (+)-α-thujone and (−)-β-thujone. In 2016, they were found in nature as well, in ''Salvia officinalis''. File:(-)-alpha-Thujon.svg, (−)-α-thujone File:Alpha-(+)-Thu ...
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Absinthe
Absinthe (, ) is an anise-flavored Liquor, spirit derived from several plants, including the flowers and leaves of ''Artemisia absinthium'' ("grand wormwood"), together with green anise, sweet fennel, and other medicinal and culinary herbs. Historically described as a highly alcoholic spirit, it is 45–74% Alcohol by volume, ABV or 90–148 proof in the US. Absinthe traditionally has a natural green colour but may also be colourless. It is commonly referred to in historical literature as . While sometimes casually referred to as a liqueur, absinthe is not traditionally bottled with sugar or sweeteners. Absinthe is traditionally bottled at a high level of alcohol by volume, but it is normally diluted with water before being consumed. Absinthe was created in the canton of Neuchâtel in Switzerland in the late 18th century by the France, French physician Pierre Ordinaire. It rose to great popularity as an alcoholic drink in late 19th- and early 20th-century France, particularly a ...
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Tansy
Tansy (''Tanacetum vulgare'') is a perennial, herbaceous flowering plant in the genus ''Tanacetum'' in the aster family, native to temperate Europe and Asia. It has been introduced to other parts of the world, including North America, and in some areas has become invasive. It is also known as common tansy, bitter buttons, cow bitter, or golden buttons. The Latin word ''vulgare'' means "common". Description Tansy is a flowering herbaceous plant with finely divided compound leaves and yellow, button-like flowers. It has a stout, somewhat reddish, erect stem, usually smooth, tall, and branching near the top. The leaves are alternate, long and are pinnately lobed, divided almost to the center into about seven pairs of segments, or lobes, which are again divided into smaller lobes having saw-toothed edges, giving the leaf a somewhat fern-like appearance. The roundish, flat-topped, button-like, yellow flower heads are produced in terminal clusters from mid-to-late summer. The ...
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Artemisia Absinthium
''Artemisia absinthium'', otherwise known as common wormwood, is a species of '' Artemisia'' native to North Africa and temperate regions of Eurasia, and widely naturalized in Canada and the northern United States. It is grown as an ornamental plant and is used as an ingredient in the spirit absinthe and some other alcoholic beverages. Etymology Wormwood's relative mugwort was traditionally used as a remedy for a variety of complaints, especially those of a gynaecological nature, and so the wormwood genus bears the name of the Greek goddess of childbirth, Artemis. The specific name derives from ''apsínthion'', the Greek term for the plant. "Wormwood" itself is an alteration of Old English ''wermod'', which is of obscure origin. The German cognate ''Wermut'' is the source of the term vermouth, used in French and English to describe a kind of wine traditionally flavoured with wormwood. Description ''A. absinthium'' is a herbaceous perennial plant with fibrous roots. The stem ...
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Mugwort
Mugwort is a common name for several species of aromatic flowering plants in the genus '' Artemisia.'' In Europe, mugwort most often refers to the species '' Artemisia vulgaris'', or common mugwort. In East Asia the species '' Artemisia argyi'' is often called "Chinese mugwort" in the context of traditional Chinese medicine, Ngai Chou in Cantonese or () for the whole plant in Mandarin, and () for the leaf, which is used specifically in the practice of moxibustion. '' Artemisia princeps'' is a mugwort known in Korea as () and in Japan as (). While other species are sometimes referred to by more specific common names, they may be called simply "mugwort" in many contexts. Etymology The Anglo-Saxon ''Nine Herbs Charm'' mentions . A folk etymology, based on coincidental sounds, derives ' from the word "mug"; more certainly, it has been used in flavoring drinks at least since the early Iron Age. * Other sources say ''mugwort'' is derived from the Old Norse (meaning "marsh") and ...
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Thuja
''Thuja'' ( ) is a genus of coniferous tree or shrub in the Cupressaceae (cypress family). There are five species in the genus, two native to North America and three native to eastern Asia. The genus is monophyletic and sister to ''Thujopsis''. Members are commonly known as arborvitaes (from the Latin term for 'tree of life'), thujas or cedars. Description ''Thuja'' are evergreen trees growing from tall, with stringy-textured reddish-brown Bark (botany), bark. The shoots are flat, with side shoots only in a single plane. The leaves are scale-like and long, except young seedlings in their first year, which have needle-like leaves. The scale leaves are arranged in alternating decussate pairs in four rows along the twigs. The male cones are small, inconspicuous, and are located at the tips of the twigs. The female conifer cone, cones start out similarly inconspicuous, but grow to about long at maturity when 6–8 months old; they have 6-12 overlapping, thin, leathery scales, each ...
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Common Sage
''Salvia officinalis'', the common sage or sage, is a perennial, evergreen subshrub, with woody stems, grayish leaves, and blue to purplish flowers. It is a member of the mint family Lamiaceae and native to the Mediterranean region, though it has been naturalized in many places throughout the world. It has a long history of medicinal and culinary use, and in modern times it has been used as an ornamental garden plant. The common name "sage" is also used for closely related species and cultivars. Description Cultivars are quite variable in size, leaf and flower color, and foliage pattern, with many variegated leaf types. The Old World type grows to approximately tall and wide, with lavender flowers most common, though they can also be white, pink, or purple. The plant flowers in late spring or summer. The leaves are oblong, ranging in size up to long by wide. Leaves are grey-green, rugose on the upper side, and nearly white underneath due to the many short soft hairs. Modern ...
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GABAA Receptor
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous Ligand (biochemistry), ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Accurate regulation of GABAergic transmission through appropriate developmental processes, specificity to neural cell types, and responsiveness to activity is crucial for the proper functioning of nearly all aspects of the central nervous system (CNS). Upon opening, the GABAA receptor on the Chemical synapse, postsynaptic cell is selectively permeable to Chloride, chloride ions () and, to a lesser extent, Bicarbonate, bicarbonate ions (). GABAAR are members of the ligand-gated ion channel receptor superfamily, which is a chloride channel family with a dozen or more heterotetrametric subtypes and 19 distinct subunits. These subtypes have distinct brain regional and subcellular localization, age-dependent expression, and the ability to undergo plastic alt ...
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Artemisia (plant)
''Artemisia'' ( ) is a large, diverse genus of plants belonging to the daisy family, Asteraceae, with almost 500 species. Common names for various species in the genus include mugwort, Artemisia absinthium, wormwood, and sagebrush. Some botanists split the genus into several genera, but DNA analysis does not support the maintenance of the genera ''Crossostephium'', ''Filifolium'', ''Neopallasia'', ''Seriphidium'', and ''Sphaeromeria''; three other segregate (taxonomy), segregate genera—''Stilnolepis'', ''Elachanthemum'', and ''Kaschgaria''—are maintained by this evidence. Occasionally, some of the species are called sages, causing confusion with the ''Salvia'' sages in the family Lamiaceae. ''Artemisia'' comprises hardiness (plants), hardy herbaceous plants and shrubs, which are known for the powerful chemical constituents in their essential oils. ''Artemisia'' species grow in temperate climates of both hemispheres, usually in dry or semiarid habitats. Notable species include ...
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Ball-and-stick Model
In chemistry, the ball-and-stick model is a molecular model of a chemical substance which displays both the Molecular geometry, three-dimensional position of the atoms and the chemical bond, bonds between them. The atoms are typically represented by sphere (geometry), spheres, connected by rods which represent the bonds. Double bond, Double and triple bonds are usually represented by two or three curved rods, respectively, or alternately by correctly positioned sticks for the sigma bond, sigma and pi bonds. In a good model, the angles between the rods should be the same as the Bond angle, angles between the bonds, and the distances between the centers of the spheres should be proportional to the distances between the corresponding atomic nucleus, atomic nuclei. The chemical element of each atom is often indicated by the sphere's color. In a ball-and-stick model, the radius of the spheres is usually much smaller than the rod lengths, in order to provide a clearer view of the atoms ...
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Mentha
''Mentha'', also known as mint (from Greek , Linear B ''mi-ta''), is a genus of flowering plants in the mint family, Lamiaceae. It is estimated that 13 to 24 species exist, but the exact distinction between species is unclear. Hybridization occurs naturally where some species' ranges overlap. Many hybrids and cultivars are known. The genus has a subcosmopolitan distribution, growing best in wet environments and moist soils. Description Mints are aromatic, almost exclusively perennial herbs. They have wide-spreading underground and overground stolons and erect, square, branched stems. Mints will grow tall and can spread over an indeterminate area. Due to their tendency to spread unchecked, some mints are considered invasive. The leaves are arranged in opposite pairs, from oblong to lanceolate, often downy, and with a serrated margin. Leaf colors range from dark green and gray-green to purple, blue, and sometimes pale yellow. The flowers are produced in long bracts ...
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Geranyl Diphosphate
Geranyl pyrophosphate (GPP), also known as geranyl diphosphate (GDP), is the pyrophosphate ester of the terpenoid geraniol. Its salts are colorless. It is a precursor to many thousands of natural products. Occurrence GPP is an intermediate in the isoprenoid biosynthesis pathway that produces longer prenyl chains such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate as well as many terpenes. It can be prepared in the laboratory from geraniol. Microbial toxicity Intracellularly produced GPP has been shown to be toxic to the bacteria '' E. coli'' at moderate doses. Related compounds * Geraniol * Farnesyl pyrophosphate * Geranylgeranyl pyrophosphate Geranylgeranyl pyrophosphate is an intermediate in the biosynthesis of diterpenes and diterpenoids. It is also the precursor to carotenoids, gibberellins, tocopherols, and chlorophylls. It is also a precursor to geranylgeranylated proteins, whic ... See also * Dimethylallyltranstransferase References Further reading ...
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