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Thrifty Gene Hypothesis
The thrifty gene hypothesis is an attempt by geneticist James V. Neel to explain why certain populations and subpopulations in the modern day are prone to diabetes mellitus type 2. He proposed the hypothesis in 1962 to resolve a problem: diabetes is a harmful medical condition, yet it is also common, and has a strong genetic basis. The problem is to understand how disease with a likely genetic component and with such negative effects may have been favoured by the process of natural selection. Neel suggested the resolution to this problem is that genes which predispose to diabetes (called 'thrifty genes') were historically advantageous, but they became detrimental in the modern world. In his words they were "rendered detrimental by 'progress'". Neel's primary interest was in diabetes, but the idea was soon expanded to encompass obesity as well. Thrifty genes are genes which enable individuals to efficiently collect and process food to deposit fat during periods of food abundance in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geneticist
A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processes or develop genetic technologies to aid in the pharmaceutical or and agriculture industries. Some geneticists perform experiments in model organisms such as '' Drosophila'', '' C. elegans'', zebrafish, rodents or humans and analyze data to interpret the inheritance of biological traits. A basic science geneticist is a scientist who usually has earned a PhD in genetics and undertakes research and/or lectures in the field. A medical geneticist is a physician who has been trained in medical genetics as a specialization and evaluates, diagnoses, and manages patients with hereditary conditions or congenital malformations; and provides genetic risk calculations and mutation analysis. Education Geneticists participate in courses from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Western Pattern Diet
The Western pattern diet is a modern dietary pattern originating in the industrialized West which is generally characterized by high intakes of pre-packaged foods, refined grains, red and processed meat, high-sugar drinks, candy and sweets, fried foods, high-fat dairy products (such as butter), eggs, potato products, and corn products (including high-fructose corn syrup). Conversely, there are generally low intakes of fruits, vegetables, whole grains, fish, nuts, and seeds. The nature of production also affects the nutrient profile, as in the example of industrially produced animal products versus pasture-raised animal products. Dietary pattern analysis focuses on overall diets (such as the Mediterranean diet) rather than individual foods or nutrients. Compared to a so-called "prudent pattern diet", which has higher proportions of "fruit, vegetables, whole grains, and poultry", the Western pattern diet is associated with higher risks of cardiovascular disease and ob ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chittaranjan Yajnik
Chittaranjan Yajnik is a medical scientist from Pune, India who is a specialist in diabetes research and maternal nutrition. Yajnik is known for his work on the topic of the ‘thin-fat’ Indian, which explains that though not obese by international criteria Indians are adipose (high body fat percent). He has worked in the field of intrauterine programming of diabetes and was successful in showing possible role of maternal micronutrient nutrition in its aetiology Etiology (; alternatively spelled aetiology or ætiology) is the study of causation or origination. The word is derived from the Greek word ''()'', meaning "giving a reason for" (). More completely, etiology is the study of the causes, origin .... In 2024, he was featured among the top 2% of researchers worldwide, Stanford’s 2024 top 2% list, released in collaboration with Elsevier. References External links Profile of Dr. Yajnik at WHO websiteA presentation by Dr. Yajnik regarding the concept of 'Thi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Regulatory Network
A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell. GRN also play a central role in morphogenesis, the creation of body structures, which in turn is central to evolutionary developmental biology (evo-devo). The regulator can be DNA, RNA, protein or any combination of two or more of these three that form a complex, such as a specific sequence of DNA and a transcription factor to activate that sequence. The interaction can be direct or indirect (through transcribed RNA or translated protein). In general, each mRNA molecule goes on to make a specific protein (or set of proteins). In some cases this protein will be structural, and will accumulate at the cell membrane or within the cell to give it particular structural properties. In other cases the protein will be an enz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canalisation (genetics)
Canalisation is a measure of the ability of a population to produce the same phenotype regardless of variability of its environment or genotype. It is a form of robustness (evolution), evolutionary robustness. The term was coined in 1942 by C. H. Waddington to capture the fact that "developmental reactions, as they occur in organisms submitted to natural selection...are adjusted so as to bring about one definite end-result regardless of minor variations in conditions during the course of the reaction". He used this word rather than robustness to consider that biological systems are not robust in quite the same way as, for example, engineered systems. Biological robustness or canalisation comes about when developmental biology, developmental pathways are evolutionary developmental biology, shaped by evolution. Waddington introduced the concept of the epigenetic landscape, in which the state of an organism rolls "downhill" during development. In this metaphor, a canalised trait is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipid Metabolism
Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown and storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. In animals, these fats are obtained from food and are synthesized by the liver. Lipogenesis is the process of synthesizing these fats. The majority of lipids found in the human body from ingesting food are triglycerides and cholesterol. Other types of lipids found in the body are fatty acids and membrane lipids. Lipid metabolism is often considered the digestion and absorption process of dietary fat; however, there are two sources of fats that organisms can use to obtain energy: from consumed dietary fats and from stored fat. Vertebrates (including humans) use both sources of fat to produce energy for organs such as the heart to function. Since lipids are hydrophobic molecules, they need to be solubilized before their metabolism can begin. Lipid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Body Mass Index
Body mass index (BMI) is a value derived from the mass (Mass versus weight, weight) and height of a person. The BMI is defined as the human body weight, body mass divided by the square (algebra), square of the human height, body height, and is expressed in Units of measurement, units of kg/m2, resulting from mass in kilograms (kg) and height in metres (m). The BMI may be determined first by measuring its components by means of a weighing scale and a stadiometer. The multiplication and division may be carried out directly, by hand or using a calculator, or indirectly using a lookup table (or chart). The table displays BMI as a function of mass and height and may show other units of measurement (converted to Metric system, metric units for the calculation). The table may also show contour lines or colours for different BMI categories. The BMI is a convenient rule of thumb used to broadly categorize a person as based on tissue mass (muscle, fat, and bone) and height. Major adult B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anthropology
Anthropology is the scientific study of humanity, concerned with human behavior, human biology, cultures, society, societies, and linguistics, in both the present and past, including archaic humans. Social anthropology studies patterns of behaviour, while cultural anthropology studies cultural meaning, including norms and values. The term sociocultural anthropology is commonly used today. Linguistic anthropology studies how language influences social life. Biological anthropology, Biological (or physical) anthropology studies the biology and evolution of Human evolution, humans and their close primate relatives. Archaeology, often referred to as the "anthropology of the past," explores human activity by examining physical remains. In North America and Asia, it is generally regarded as a branch of anthropology, whereas in Europe, it is considered either an independent discipline or classified under related fields like history and palaeontology. Etymology The abstract noun ''wikt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paleolithic
The Paleolithic or Palaeolithic ( years ago) ( ), also called the Old Stone Age (), is a period in human prehistory that is distinguished by the original development of stone tools, and which represents almost the entire period of human prehistoric technology. It extends from the earliest known use of stone tools by Hominini, hominins, 3.3 million years ago, to the end of the Pleistocene, 11,650 Before Present#Radiocarbon calibration, cal Before Present, BP. The Paleolithic Age in Europe preceded the Mesolithic Age, although the date of the transition varies geographically by several thousand years. During the Paleolithic Age, hominins grouped together in small societies such as band society, bands and subsisted by gathering plants, fishing, and hunting or scavenging wild animals. The Paleolithic Age is characterized by the use of Knapping, knapped stone tools, although at the time humans also used wood and bone tools. Other organic commodities were adapted for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Famine
A famine is a widespread scarcity of food caused by several possible factors, including, but not limited to war, natural disasters, crop failure, widespread poverty, an Financial crisis, economic catastrophe or government policies. This phenomenon is usually accompanied or followed by regional malnutrition, starvation, epidemic, and increased death, mortality. Every inhabited continent in the world has experienced a period of famine throughout history. During the 19th and 20th centuries, Southeast Asia, Southeast and South Asia, as well as Eastern Europe, Eastern and Central Europe, suffered the greatest number of fatalities due to famine. Deaths caused by famine declined sharply beginning in the 1970s, with numbers falling further since 2000. Since 2010, Africa has been the most affected continent in the world by famine. As of 2025, Haiti and Afghanistan are the two states with the most catastrophic and widespread states of famine, followed by Palestine (confined to Gaza Strip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inuit
Inuit (singular: Inuk) are a group of culturally and historically similar Indigenous peoples traditionally inhabiting the Arctic and Subarctic regions of North America and Russia, including Greenland, Labrador, Quebec, Nunavut, the Northwest Territories, Yukon (traditionally), Alaska, and the Chukotsky District of Chukotka Autonomous Okrug. The Inuit languages are part of the Eskaleut languages, also known as Inuit-Yupik-Unangan, and also as Eskimo–Aleut. Canadian Inuit live throughout most of Northern Canada in the territory of Nunavut, Nunavik in the northern third of Quebec, the Nunatsiavut in Labrador, and in various parts of the Northwest Territories and Yukon (traditionally), particularly around the Arctic Ocean, in the Inuvialuit Settlement Region. These areas are known, by Inuit Tapiriit Kanatami and the Government of Canada, as Inuit Nunangat. In Canada, sections 25 and 35 of the Constitution Act of 1982 classify Inuit as a distinctive group of Abo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Southwestern United States
The Southwestern United States, also known as the American Southwest or simply the Southwest, is a geographic and cultural list of regions of the United States, region of the United States that includes Arizona and New Mexico, along with adjacent portions of California, Colorado, Nevada, Oklahoma, Texas, and Utah. The largest cities by List of metropolitan statistical areas, metropolitan area are Phoenix, Arizona, Phoenix, Las Vegas, El Paso, Texas, El Paso, Albuquerque, and Tucson, Arizona, Tucson. Before 1848, in the historical region of Santa Fe de Nuevo México as well as parts of Alta California and Coahuila y Tejas, settlement was almost non-existent outside of New Mexico's pueblos and Santa Fe de Nuevo México#Regions and municipalities, Spanish or Mexican municipalities. Much of the area had been a part of New Spain and Mexico until the United States acquired the area through the Treaty of Guadalupe Hidalgo in 1848 and the smaller Gadsden Purchase in 1854. While the regio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
