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Tetra-amelia Syndrome
Tetra-amelia syndrome (''tetra-'' + '' amelia''), also called autosomal recessive tetraamelia, is an extremely rare autosomal recessive congenital disorder characterized by the absence of all four limbs. Other areas of the body are also affected by malformations, such as the face, skull, reproductive organs, anus, lungs and pelvis. The disorder can be caused by recessive mutations in the WNT3 or RSPO2 genes. Presentation Tetra-amelia syndrome is characterized by the complete absence of all four limbs. The syndrome causes severe malformations of various parts of the body, including the face and head, heart, nervous system, skeleton, and genitalia. In many cases, the lungs are underdeveloped, which makes breathing difficult or impossible. Because children with tetra-amelia syndrome have such serious medical problems, most are stillborn or die shortly after birth. Cause RSPO2 and WNT3 genes Researchers have found loss-of-function mutations in the WNT3 or the RSPO2 genes in peop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Violetta (performer)
Aloisia Wagner (1905 or 1906 – ), better known by her stage name Violetta, was a German-American woman who was born without legs or arms with a condition known as tetra-amelia syndrome. She was born in Hemelingen, Germany, and had a lengthy career in sideshow performance. Aloisia Wagner was born in either 1905 or 1906. Her exact date of birth is unknown. On March 23, 1924, she left her birth city of Bremen-Hemelingen, Germany, with her stepbrother and manager, Karl Grobecker, aboard the , which arrived in New York on April 3, 1924. According to the ship manifest, Aloisia had blonde hair and green eyes, was three feet tall, and was allowed into the U.S. for 25 weeks to work for Samuel W. Gumpertz in his Dreamland Circus Side Show. She was the daughter of Elise Wagner, of Hemelingen, Moltkestr. 26 (map). The manifest's "Held For Special Inquiry" page shows that both were held (in the hospital) for one day before being allowed to enter the U.S. Other pages of the manifest fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Carrier
A hereditary carrier (genetic carrier or just carrier), is a person or other organism that has inherited a recessive allele for a genetic trait or mutation but usually does not display that trait or show symptoms of the disease. Carriers are, however, able to pass the allele onto their offspring, who may then express the genetic trait. Carriers in autosomal inheritances Autosomal dominant-recessive inheritance is made possible by the fact that the individuals of most species (including all higher animals and plants) have two alleles of most hereditary predispositions because the chromosomes in the cell nucleus are usually present in pairs (diploid). Carriers can be female or male as the autosomes are homologous independently from the sex. In carriers the expression of a certain characteristic is recessive. The individual has both a genetic predisposition for the dominant trait and a genetic predisposition for the recessive trait, and the dominant expression prevails in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sideshow
In North America, a sideshow is an extra, secondary production associated with a circus, traveling carnival, carnival, fair, or other such attraction. They historically featured human oddity exhibits (so-called “Freak show, freak shows”), preserved specimens (real or fabricated, such as the Fiji mermaid, Fiji Mermaid), live animal acts, burlesque or Striptease, strip shows, actually or ostensibly dangerous stunts, or stunts that appear painful like human blockhead. Most modern sideshows feature fewer to no animal acts, and have a greater focus on trainable feats or consensual body modification rather than exhibiting people with congenital disabilities, either due to changing public opinion or local laws prohibiting the exhibition of disabled people or animals. Trainable acts associated with sideshows include sword swallowing, Fire breathing (circus act), fire breathing and manipulation, Magic (illusion), magic and visual illusions, human blockhead, knife throwing, lying on a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guyanese People
The people of Guyana, or Guyanese, come from a wide array of backgrounds and cultures including aboriginal natives, African and Indian origins, as well as a minority of Chinese and European descendant peoples. Demographics as of 2012 are Indo-Guyanese 39.8%, Afro-Guyanese 30.1%, mixed race (mostly Dougla) 19.9%, Amerindian 10.5%, other 1.5% (including Chinese and Europeans, such as the Portuguese). As a result, Guyanese do not equate their nationality with race and ethnicity, but with citizenship. Although citizens make up the majority of Guyanese, there is a substantial number of Guyanese expatriates, dual citizens and descendants living worldwide, chiefly elsewhere in the Anglosphere. Located on the northern coast of South America, Guyana is part of the main land Caribbean which is part of the historical British West Indies. It is culturally similar to Suriname and nearby island nations of the Caribbean such as Trinidad and Tobago, and is a culturally Caribbean countr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prince Randian
Prince Randian (sometimes misspelled Rardion or Randion; October 12, 1871 – December 19, 1934), also nicknamed Pillow Man, The Snake Man, The Human Torso, The Human Caterpillar and a variety of other names, was a Guyanese-born American performer with tetra-amelia syndrome and a famous limbless sideshow performer of the early 1900s, best known for his ability to roll cigarettes with his lips. He was brought to the United States by P.T. Barnum in 1889, at the age of 18, and was a popular Coney Island carnival and circus attraction for 45 years. In 1932, he was featured in the film '' Freaks'', in which he is seen lighting up a cigarette with a match. Personal life Randian (whose birth name is unknown) was born with no arms or legs in Demerara, British Guiana. He was Hindu and spoke Hindi, English, French, and German. According to a passenger manifest of SS ''Parima'' from April 14, 1917, he had lived previously at Charlotte Amalie, Saint Thomas, U.S. Virgin Islands. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States
The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 contiguous states border Canada to the north and Mexico to the south, with the semi-exclave of Alaska in the northwest and the archipelago of Hawaii in the Pacific Ocean. The United States asserts sovereignty over five Territories of the United States, major island territories and United States Minor Outlying Islands, various uninhabited islands in Oceania and the Caribbean. It is a megadiverse country, with the world's List of countries and dependencies by area, third-largest land area and List of countries and dependencies by population, third-largest population, exceeding 340 million. Its three Metropolitan statistical areas by population, largest metropolitan areas are New York metropolitan area, New York, Greater Los Angeles, Los Angel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Australia
Australia, officially the Commonwealth of Australia, is a country comprising mainland Australia, the mainland of the Australia (continent), Australian continent, the island of Tasmania and list of islands of Australia, numerous smaller islands. It has a total area of , making it the list of countries and dependencies by area, sixth-largest country in the world and the largest in Oceania. Australia is the world's flattest and driest inhabited continent. It is a megadiverse countries, megadiverse country, and its size gives it a wide variety of landscapes and Climate of Australia, climates including deserts of Australia, deserts in the Outback, interior and forests of Australia, tropical rainforests along the Eastern states of Australia, coast. The ancestors of Aboriginal Australians began arriving from south-east Asia 50,000 to 65,000 years ago, during the Last Glacial Period, last glacial period. By the time of British settlement, Aboriginal Australians spoke 250 distinct l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evangelism
Evangelism, or witnessing, is the act of sharing the Christian gospel, the message and teachings of Jesus Christ. It is typically done with the intention of converting others to Christianity. Evangelism can take several forms, such as personal conversations, preaching, media, and is especially associated with missionary work. Christians who specialize in evangelism are often known as evangelists, whether they are in their home communities or living as missionaries in the field, although some Christian traditions refer to such people as ''missionaries'' in either case. Some Christian traditions consider evangelists to be in a leadership position; they may be found preaching to large meetings or in governance roles. In addition, Christian groups who encourage evangelism are sometimes known as evangelistic or ''evangelist''. Etymology The word ''evangelist'' comes from the Koine Greek word (transliterated as ''euangelion'') via Latinised ''evangelium'' as used in the canonic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Without Limbs
Nicholas James Vujicic ( ; born 4 December 1982) is an Australian-American Christian evangelist and motivational speaker of Serbian descent. Vujicic has tetra-amelia syndrome, a condition characterised by the absence of arms and legs. Early life Vujicic was born in Melbourne, Australia, in 1982 to Dušanka and Borislav Vujičić, Serbian immigrants from Yugoslavia. He was raised Serbian Orthodox in his earliest years, but the family later converted to Protestantism. Vujicic's father is a pastor in the Apostolic Christian Church. Vujicic was born with tetra-amelia syndrome, a rare disability characterised by the absence of arms and legs. According to Vujicic's autobiography, his mother refused to see him or hold him immediately after his birth; instead, she and her husband left the hospital. He was bullied at school because of his medical condition. At one point, Vujicic attempted to commit suicide by drowning himself in a bathtub, but he was saved. While Vujicic's parents initi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hirotada Ototake
(born April 6, 1976) is a Japanese writer from Tokyo, who has written in the memoir, fiction and sports journalism genres. Biography Ototake was born without arms and legs due to tetra-amelia syndrome, a genetic disorder. Ototake is most notable for his 1998 memoir (). Within a year of publication, the book became the third-best-selling book in Japan since World War II. It has since been translated into English. After publishing his autobiography, Ototake became a successful sports journalist. In 2007, he took a job as a primary school (first through sixth grades) teacher at Suginami Dai-Yon Elementary School in Tokyo. He starred in ''Daijōbu 3-Gumi'' (; English title: ''Nobody's Perfect''), a 2013 film based on the events of his own life as a teacher. The Liberal Democratic Party considered recruiting Ototake to run in the summer 2016 upper house elections. In 2015, Ototake entered National Graduate Institute for Policy Studies as a Masters student. However, in March 2016, s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United Nations
The United Nations (UN) is the Earth, global intergovernmental organization established by the signing of the Charter of the United Nations, UN Charter on 26 June 1945 with the stated purpose of maintaining international peace and international security, security, to develop friendly Diplomacy, relations among State (polity), states, to promote international cooperation, and to serve as a centre for harmonizing the actions of states in achieving those goals. The United Nations headquarters is located in New York City, with several other offices located in United Nations Office at Geneva, Geneva, United Nations Office at Nairobi, Nairobi, United Nations Office at Vienna, Vienna, and The Hague. The UN comprises six principal organizations: the United Nations General Assembly, General Assembly, the United Nations Security Council, Security Council, the United Nations Economic and Social Council, Economic and Social Council, the International Court of Justice, the United Nations Se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
