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Temafloxacin
Temafloxacin (marketed by Abbott Laboratories as Omniflox) is a fluoroquinolone antibiotic drug which was withdrawn from sale in the United States shortly after its approval in 1992 because of serious adverse effects resulting in three deaths. It is not marketed in Europe. History Omniflox was approved to treat lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections in the United States by the Food and Drug Administration in January 1992. Severe adverse reactions, including allergic reactions and hemolytic anemia, developed in over 100 patients during the first four months of its use, leading to three patient deaths. Abbott withdrew the drug from sale in June 1992. Pharmacokinetics Following oral administration the compound is well absorbed from the gastrointestinal tract. The oral bioavailability is greater than 90%. Temafloxacin has a good tissue penetration in various biological fluids and tissues, particularly in the resp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluoroquinolone
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production. Quinolone antibiotics are classified into four generations based on their spectrum of activity and chemical modifications. The first-generation quinolones, such as nalidixic acid, primarily target Gram-negative bacteria and are mainly used for urinary tract infections. Second-generation quinolones introduced fluorine atoms into their structure, creating fluoroquinolones, which significantly expanded their antibacterial activity to include some Gram-positive bacteria. Third-generation fluoroquinolones further improved Gram-positive coverage, while fourth-generation fluoroquinolones offer broad-spectrum activity, including anaerobic bacteria. Only quinolone antibiotics in generati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluoroquinolone Antibiotics
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production. Quinolone antibiotics are classified into four generations based on their spectrum of activity and chemical modifications. The first-generation quinolones, such as nalidixic acid, primarily target Gram-negative bacteria and are mainly used for urinary tract infections. Second-generation quinolones introduced fluorine atoms into their structure, creating fluoroquinolones, which significantly expanded their antibacterial activity to include some Gram-positive bacteria. Third-generation fluoroquinolones further improved Gram-positive coverage, while fourth-generation fluoroquinolones offer broad-spectrum activity, including anaerobic bacteria. Only quinolone antibiotics in generation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quinolone Antibiotic
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production. Quinolone antibiotics are classified into four generations based on their spectrum of activity and chemical modifications. The first-generation quinolones, such as nalidixic acid, primarily target Gram-negative bacteria and are mainly used for urinary tract infections. Second-generation quinolones introduced fluorine atoms into their structure, creating fluoroquinolones, which significantly expanded their antibacterial activity to include some Gram-positive bacteria. Third-generation fluoroquinolones further improved Gram-positive coverage, while fourth-generation fluoroquinolones offer broad-spectrum activity, including anaerobic bacteria. Only quinolone antibiotics in generat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abbott Laboratories
Abbott Laboratories is an American multinational medical devices and health care company with headquarters in Abbott Park, Illinois, in the United States. The company was founded by Chicago physician Wallace Calvin Abbott in 1888 to formulate known drugs; today, it sells medical devices, diagnostics, branded generic medicines and nutritional products. It split off its research-based pharmaceuticals business into AbbVie in 2013. Abbott's products include Pedialyte, Similac, BinaxNOW, Ensure, Glucerna, ZonePerfect, FreeStyle Libre, i-STAT and MitraClip. History Foundation and early history In 1888 at the age of 30, Wallace Abbott (1857–1921), an 1885 graduate of the University of Michigan, founded the Abbott Alkaloidal Company in Ravenswood, Chicago. At the time, he was a practising physician and owned a drug store. His innovation was formulating the active part of alkaloid Herbalism, medicinal plants—morphine, quinine, strychnine and codeine—as tiny "dosimetric gra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Withdrawn Drugs
Withdrawal means "an act of taking out" and may refer to: * Anchoresis (withdrawal from the world for religious or ethical reasons) * ''Coitus interruptus'' (the withdrawal method) * Drug withdrawal * Social withdrawal * Taking of money from a bank * Water withdrawal * Withdrawal (military) * Withdrawal reflex * ''Withdrawal'', Twista Carl Terrell Mitchell (born November 27, 1973), better known by his stage name Twista (also known as Tung Twista), is an American rapper. He is best known for his Chopper (rap), chopper style of rapping and for once holding the title of fastest .../ Do or Die EP * "Withdrawals" (Tyler Farr song) See also * * {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatotoxins
Hepatotoxicity (from ''hepatic toxicity'') implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in Drug overdose, overdoses (e.g. Paracetamol, acetaminophen, paracetamol) and sometimes even when introduced within Therapeutic index, therapeutic ranges (e.g. halothane), may injure the organ. Other chemical agents, such as those used in laboratories and industries, natural chemicals (e.g., alpha-amanitin), and Herbalism, herbal remedies (two prominent examples being kava, though the causal mechanism is unknown, and comfrey, through pyrrolizidine alkaloid content) can also induce hepatotoxicity. Chemicals that cause liver injury are called hep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Soft Tissue
Soft tissue connective tissue, connects and surrounds or supports internal organs and bones, and includes muscle, tendons, ligaments, Adipose tissue, fat, fibrous tissue, Lymphatic vessel, lymph and blood vessels, fasciae, and synovial membranes. Soft tissue is Tissue (biology), tissue in the body that is not hard tissue, hardened by the processes of ossification or calcification such as bones and teeth. It is sometimes defined by what it is not – such as "nonepithelial, extraskeletal mesenchyme exclusive of the reticuloendothelial system and glia". Composition The characteristic substances inside the extracellular matrix of soft tissue are the collagen, elastin and ground substance. Normally the soft tissue is very hydrated because of the ground substance. The fibroblasts are the most common cell responsible for the production of soft tissues' fibers and ground substance. Variations of fibroblasts, like chondroblasts, may also produce these substances. Mechanical character ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Skin Infection
A skin infection is an infection of the skin in humans and other animals, that can also affect the associated soft tissues such as loose connective tissue and mucous membranes. They comprise a category of infections termed skin and skin structure infections (SSSIs), or skin and soft tissue infections (SSTIs), and acute bacterial SSSIs (ABSSSIs). They are distinguished from dermatitis (inflammation of the skin), although skin infections can result in skin inflammation. Causes Bacterial Bacterial skin infections affected about 155 million people and cellulitis occurred in about 600 million people in 2013. Bacterial skin infections include: * Cellulitis, a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Further, cellulitis can be classified based into purulent and non-purulent cellulitis, based on the most likely causative agent and the symptoms presentation. Purulent cellulitis is often caused by ''Staphylococcus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cervicitis
Cervicitis is inflammation of the uterine cervix. Cervicitis in women has many features in common with urethritis in men and many cases are caused by sexually transmitted infections. Non-infectious causes of cervicitis can include intrauterine devices, contraceptive diaphragms, and allergic reactions to spermicides or latex condoms. Cervicitis affects over half of all women during their adult life. Cervicitis may ascend and cause endometritis and pelvic inflammatory disease (PID). Cervicitis may be acute or chronic. Symptoms and signs Cervicitis may have no symptoms. If symptoms do manifest, they may include: * Abnormal vaginal bleeding after intercourse after periods * Unusual gray, white, or yellow vaginal discharge * Painful sexual intercourse * Pain in the vagina * Pressure or heaviness in the pelvis * Frequent, painful urination Causes Cervicitis can be caused by any of a number of infections, of which the most common are chlamydia and gonorrhea, with chlamydia a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-gonococcal Urethritis
Nongonococcal urethritis (NGU) is inflammation of the urethra that is not caused by gonorrheal infection. For treatment purposes, doctors usually classify infectious urethritis in two categories: gonococcal urethritis, caused by gonorrhea, and nongonococcal urethritis (NGU). Symptoms and signs The symptoms of urethritis can include pain or a burning sensation upon urination (dysuria), a white/cloudy discharge and a feeling that one needs to pass urine frequently. For men, the signs and symptoms are discharge from the penis, burning or pain when urinating, itching, irritation, or tenderness. In women, the signs and symptoms are discharge from vagina, burning or pain when urinating, anal or oral infections, abdominal pain, or abnormal vaginal bleeding, which may be an indication that the infection has progressed to Pelvic Inflammatory Disease. NGU is transmitted by touching the mouth, penis, vagina or anus by penis, vagina or anus of a person who has NGU. NGU is more common in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gonococcal Urethritis
Gonorrhoea or gonorrhea, colloquially known as the clap, is a sexually transmitted infection (STI) caused by the bacterium ''Neisseria gonorrhoeae''. Infection may involve the genitals, mouth, or rectum. Gonorrhea is spread through sexual contact with an infected person, or from a mother to a child during birth. Infected males may experience pain or burning with urination, discharge from the penis, or testicular pain. Infected females may experience burning with urination, vaginal discharge, vaginal bleeding between periods, or pelvic pain. Complications in females include pelvic inflammatory disease and in males include inflammation of the epididymis. Many of those infected, however, have no symptoms. If untreated, gonorrhea can spread to joints or heart valves. Globally, gonorrhea affects about 0.8% of women and 0.6% of men. An estimated 33 to 106 million new cases occur each year. In 2015, it caused about 700 deaths. Diagnosis is by testing the urine, urethra in male ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prostatitis
Prostatitis is an umbrella term for a variety of medical conditions that incorporate bacterial and non-bacterial origin illnesses in the pelvic region. In contrast with the plain meaning of the word (which means "inflammation of the prostate"), the diagnosis may not always include inflammation. Prostatitis is classified into acute, chronic, asymptomatic inflammatory prostatitis, and chronic pelvic pain syndrome. In the United States, prostatitis is diagnosed in 8% of all male urologist visits and 1% of all primary care physician visits for male genitourinary symptoms. Classification The term ''prostatitis'' refers to inflammation of the tissue of the prostate gland. It may occur as an appropriate physiological response to an infection, or it may occur in the absence of infection, or there may be no inflammation of the prostate at all. In 1999, the National Institutes of Health devised a new classification system. For more specifics about each type of prostatitis, including info ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
