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Suppositories
A suppository is a dosage form used to deliver pharmaceutical drug, medications by insertion into a body orifice (any opening in the body), where it dissolves or melts to exert local or systemic effects. There are three types of suppositories, each to insert into a different sections: rectal suppositories into the rectal administration, rectum, vaginal suppositories into the Intravaginal administration, vagina, and urethral suppositories into the Urethra#Male, urethra of a male. Suppositories are ideal for infants, elderly individuals and post-operative patients, who are unable to swallow oral medications, and for individuals experiencing severe nausea and/or vomiting. Suppositories are administered through rectal route to reduce onset time of reaction. Composition Several different ingredients can be used to form the base of a suppository: cocoa butter or a similar substitute, polyethylene glycol, Gel#Hydrogels, hydrogels, and glycerinated gelatin. The type of material used depen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laxatives
Laxatives, purgatives, or aperients are substances that loosen human feces, stools and increase defecation, bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubricant, and saline water, saline laxatives are used to evacuate the Colon (anatomy), colon for rectum, rectal and bowel examinations, and may be supplemented by enemas under certain circumstances. Sufficiently high doses of laxatives may cause diarrhea. Some laxatives combine more than one active ingredient, and may be administered Oral administration, orally or Rectum#Route of administration, rectally. Types Bulk-forming agents Bulk-forming laxatives, also known as roughage, are substances, such as dietary fiber, fiber in food and hydrophilic agents in over-the-counter drugs, that add bulk and water to human feces, stools so they can pass more easily through the intestines (lower part of the digestive tract). Prope ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Artesunate Suppositories
Artesunate suppositories are used for the treatment of malaria. Artesunate is an antimalarial water-soluble derivative of dihydroartemisinin. Artemisinins are sesquiterpene lactones isolated from '' Artemisia annua'', a Chinese traditional medicine. These suppositories are given rectally due to the risk of death from severe malaria, as described below. The risk of death from severe malaria is largely dependent on the time lag between the onset of symptoms and treatment. Rapid access and administration of effective treatment is therefore essential. For many patients, readily available oral drugs cannot be taken because of their symptoms (e.g., vomiting, convulsions, coma), and hospitals providing alternative, non-oral treatment are often inaccessible. The drug artesunate, given in rectal suppository form, provides a potential solution to this problem: it can be made available in remote areas and thus can be given at the onset of symptoms. Artesunate is one of a number of artemis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rectum
The rectum (: rectums or recta) is the final straight portion of the large intestine in humans and some other mammals, and the gut in others. Before expulsion through the anus or cloaca, the rectum stores the feces temporarily. The adult human rectum is about long, and begins at the rectosigmoid junction (the end of the sigmoid colon) at the level of the third sacral vertebra or the sacral promontory depending upon what definition is used. Its diameter is similar to that of the sigmoid colon at its commencement, but it is dilated near its termination, forming the rectal ampulla. It terminates at the level of the anorectal ring (the level of the puborectalis sling) or the dentate line, again depending upon which definition is used. In humans, the rectum is followed by the anal canal, which is about long, before the gastrointestinal tract terminates at the anal verge. The word rectum comes from the Latin '' rēctum intestīnum'', meaning ''straight intestine''. Struc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rectal Administration
Rectal administration (colloquially known as boofing or plugging) uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels,The rectum has numerous blood vessels available to absorb drugs: upwards 2/3rds of the dose bypasses first-pass metabolism through systemic distribution and the rest is taken through the liver and metabolized via the hepatic portal system. and flow into the body's circulatory system, which distributes the drug to the body's organs and bodily systems.The organs and systems include, depending on if the drug is able to pass the blood–brain barrier (BBB) or not, the central nervous system (CNS), peripheral nervous system (PNS), cardiovascular system (CVS), et cetera. Uses Medical uses In addition to pharmacological effects, rectal administration has some properties which can be advantageous for the use in medicine. Rectal administration can allow patients to remain in the home setting ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glycerin Suppositories
Glycerol () is a simple triol compound. It is a colorless, odorless, sweet-tasting, viscous liquid. The glycerol backbone is found in lipids known as glycerides. It is also widely used as a sweetener in the food industry and as a humectant in pharmaceutical formulations. Because of its three hydroxyl groups, glycerol is miscible with water and is hygroscopic in nature. Modern use of the word glycerine (alternatively spelled glycerin) refers to commercial preparations of less than 100% purity, typically 95% glycerol. Structure Although achiral, glycerol is prochiral with respect to reactions of one of the two primary alcohols. Thus, in substituted derivatives, the stereospecific numbering labels the molecule with a ''sn''- prefix before the stem name of the molecule. Production Natural sources Glycerol is generally obtained from plant and animal sources where it occurs in triglycerides, esters of glycerol with long-chain carboxylic acids. The hydrolysis, saponification, or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rectal Stricture
A rectal stricture (rectal stenosis) is a chronic and abnormal narrowing or constriction of the lumen of the rectum which presents a partial or complete obstruction to the movement of bowel contents. A rectal stricture is located deeper inside the body compared to an anal stricture. Sometimes other terms with wider meaning are used, such as ''anorectal stricture'', ''colorectal stricture'' or ''rectosigmoid stricture''. Definition Rectal stricture has been defined as the inability to pass a rigid proctoscope (12 mm diameter) or a rigid sigmoidoscope (19 mm diameter) through the affected cross-section of rectum. If the rectal stricture is accessible during digital rectal examination, a rectal stricture may be defined as narrowing to less than one-finger breadth.Ahmad, A; Krishnamurthy, P (June 2021).Benign Rectal Strictures: A Review Article. ''Practical Gastroenterology.'' 45 (6): 16-33. Anal stricture versus rectal stricture Anal strictures are usually located at th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cocoa Butter
Cocoa butter, also called theobroma oil, is a pale-yellow, edible Vegetable oil, fat extracted from the cocoa bean (''Theobroma cacao''). It is used to make chocolate, as well as some ointments, toiletries, and pharmaceuticals. Cocoa butter has a cocoa Flavoring, flavor and aroma. Its melting point is slightly below human body temperature. It is an essential ingredient of chocolate and related confectionary products. Cocoa butter does not contain butter or other animal products; it is veganism, vegan. Extraction and composition For use in chocolate manufacture, the cocoa beans are first Solid-state fermentation, fermented and then dried. The beans are then roasted and separated from their hulls to produce cocoa nibs. About 54–58% of the cocoa nibs is cocoa butter. The cocoa nibs are ground to form Chocolate liquor, cocoa mass, also known as cocoa liquor or chocolate liquor. Chocolate liquor is pressed to separate the cocoa butter from the non-fat cocoa solids. Cocoa butt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pessary
A pessary is a prosthetic device inserted into the Human vagina, vagina for structural and pharmaceutical purposes. It is most commonly used to treat Stress incontinence, stress urinary incontinence to stop urinary leakage and to treat pelvic organ prolapse to maintain the location of organs in the pelvic region. It can also be used to administer medications locally in the vagina or as a method of contraception. Pessaries come in different shapes and sizes, so it is important that individuals be fitted for them by health care professionals to avoid any complications. However, there are a few instances and circumstances that allow pessaries to be purchased without a prescription or without seeking help from a health care professional. Some side effects may occur if pessaries are not sized properly or regularly maintained, but with the appropriate care, pessaries are generally safe and well tolerated. History Early use of pessaries dates back to the ancient Egyptians, as they d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drugs Acting On The Gastrointestinal System And Metabolism
A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via inhalation, injection, smoking, ingestion, absorption via a patch on the skin, suppository, or dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to treat, cure, prevent, or diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a regular basis for chronic disorders. Classification Pharmaceutical drugs are often classified into drug classes—groups of related drugs that have sim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dosage Forms
Dosage forms (also called unit doses) are medication, pharmaceutical drug products presented in a specific form for use. They contain a mixture of active ingredients and inactive components (excipients), configured in a particular way (such as a capsule (pharmacy), capsule shell) and apportioned into a specific dose (biochemistry), dose. For example, two products may both be amoxicillin, but one may come in 500 mg capsules, while another may be in 250 mg chewable tablets. The term unit dose can also refer to non-reusable packaging, particularly when each drug product is individually packaged. However, the FDA differentiates this by referring to it as ''unit-dose "packaging" or "dispensing"''. Depending on the context, ''multi(ple) unit dose'' may refer to multiple distinct drug products ''packaged'' together or a ''single'' product containing multiple drugs and/or doses. Formulations The term dosage form may also sometimes refer only to the pharmaceutical formulation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Constipation
Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The Human feces, stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement. Complications from constipation may include hemorrhoids, anal fissure or fecal impaction. The normal frequency of bowel movements in adults is between three per day and three per week. Babies often have three to four bowel movements per day while young children typically have two to three per day. Constipation has many causes. Common causes include slow movement of stool within the colon, irritable bowel syndrome, and pelvic floor disorders. Underlying associated diseases include hypothyroidism, diabetes, Parkinson's disease, celiac disease, non-celiac gluten sensitivity, Vitamin B12 deficiency, vitamin B12 deficiency, colon cancer, diverticulitis, and inflammatory bowel disease. Medications associated with constipation in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
