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Stratifin
Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the ''SFN'' gene in humans. The protein is named for its presence in stratified epithelial cells Epithelium or epithelial tissue is a thin, continuous, protective layer of cells with little extracellular matrix. An example is the epidermis, the outermost layer of the skin. Epithelial ( mesothelial) tissues line the outer surfaces of man .... Interactions Stratifin has been shown to interact with PLK4, ERRFI1, MARK3, JUB and YWHAG. References Further reading * * * * * * * * * * * * * * * * * * {{gene-1-stub 14-3-3 proteins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PLK4
Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the ''PLK4'' gene. The ''Drosophila'' homolog is SAK, the ''C. elegans'' homolog is zyg-1, and the ''Xenopus'' homolog is Plx4. Function ''PLK4'' encodes a member of the polo family of serine/threonine protein kinase A serine/threonine protein kinase () is a kinase enzyme, in particular a protein kinase, that phosphorylates the OH group of the amino-acid residues serine or threonine, which have similar side chains. At least 350 of the 500+ human pro ...s. The protein localizes to centrioles—complex microtubule-based structures found in centrosomes—and regulates centriole duplication during the cell cycle. Overexpression of PLK4 results in centrosome amplification, and knockdown of PLK4 results in loss of centrosomes. Structure PLK4 contains an N-terminal kinase domain (residues 12-284) and a C-terminal localization domain (residues 596-898). Other ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ERRFI1
ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ''ERRFI1'' gene. MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000). Interactions ERRFI1 has been shown to interact with Stratifin and CDC42 Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the ''CDC42'' gene. Cdc42 is involved in regulation of the cell cycle. It was originally identified in ''S. cerevisiae'' (yeast) as a mediator of .... References Further reading * * * * * * * * * * * * External links * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MARK3
MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the ''MARK3'' gene. Interactions MARK3 has been shown to interact with Stratifin Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the ''SFN'' gene in humans. The protein is named for its presence in stratified epithelial cells Epithelium or epithelial tissue is a thin, continuou .... It has been linked to a form of genetic blindness, believed to be a genetic recessive disease that progressively destroys the eyes. References Further reading * * * * * * * * * * * * * * * * EC 2.7.11 {{gene-14-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
JUB (gene)
Protein ajuba is a protein that in humans is encoded by the ''JUB'' gene. Function JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment. Interactions JUB (gene) has been shown to interact with Stratifin Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the ''SFN'' gene in humans. The protein is named for its presence in stratified epithelial cells Epithelium or epithelial tissue is a thin, continuou ... and SLC1A2. References Further reading * * * * * * * * * * * {{gene-14-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
YWHAG
14-3-3 protein gamma is a protein that in humans is encoded by the ''YWHAG'' gene. This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. Interactions YWHAG has been shown to interact with C-Raf, EPB41L3, KIF1C and Stratifin Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the ''SFN'' gene in humans. The protein is named for its presence in stratified epithelial cells Epithelium or epithelial tissue is a th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of Gene product, RNA or protein from a gene), DNA is first transcription (biology), copied into RNA. RNA can be non-coding RNA, directly functional or be the intermediate protein biosynthesis, template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population (biology), population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epithelium
Epithelium or epithelial tissue is a thin, continuous, protective layer of cells with little extracellular matrix. An example is the epidermis, the outermost layer of the skin. Epithelial ( mesothelial) tissues line the outer surfaces of many internal organs, the corresponding inner surfaces of body cavities, and the inner surfaces of blood vessels. Epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. These tissues also lack blood or lymph supply. The tissue is supplied by nerves. There are three principal shapes of epithelial cell: squamous (scaly), columnar, and cuboidal. These can be arranged in a singular layer of cells as simple epithelium, either simple squamous, simple columnar, or simple cuboidal, or in layers of two or more cells deep as stratified (layered), or ''compound'', either squamous, columnar or cuboidal. In some tissues, a layer of columnar cells may appear to be stratified d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
