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Septum Intermedium
Endocardial cushions project into the atrial canal The proper development of the atrioventricular canal into its prospective components (The heart septum and associated valves) to create a clear division between the four compartments of the heart and ensure proper blood movement through the heart, ..., and, meeting in the middle line, unite to form the septum intermedium which divides the canal into two channels, the future right and left atrioventricular orifices. References External links Overview at edu.mt Embryology of cardiovascular system {{Portal bar, Anatomy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endocardial Cushions
Endocardial cushions, or atrioventricular cushions, refer to a subset of cells in the development of the heart that play a vital role in the proper formation of the heart septa. They develop on the atrioventricular canal and conotruncal region of the bulbus cordis. During heart development, the heart starts out as a tube. As heart development continues, this tube undergoes remodeling to eventually form the four-chambered heart. The endocardial cushions are a subset of cells found in the developing heart tube that will give rise to the heart's primitive valves and septa, critical to the proper formation of a four-chambered heart. Development The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial-mesenchymal transition, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards the interior of the heart tube). These migrated cells form the "swellings" called the endocardial cushions seen in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atrial Canal
The proper development of the atrioventricular canal into its prospective components (The heart septum and associated valves) to create a clear division between the four compartments of the heart and ensure proper blood movement through the heart, are essential for proper heart function. When this process does not happen correctly, a child will develop atrioventricular canal defect which occurs in 2 out of every 10,000 births. It also has a correlation with Down syndrome because 20% of children with Down syndrome have atrioventricular canal disease as well. This is a very serious condition and surgery is necessary within the first six months of life for a child.Brown, David MD "Atrioventricular Canal Defect" Children's Hospital Boston 20120 http://www.childrenshospital.org/az/Site521/mainpageS521P0.html Half of the children who are untreated with this condition die during their first year due to heart failure or pneumonia. Atrioventricular canal defect is a combination of abnormal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
