Saralasin
Saralasin is a competitive angiotensin II receptor antagonist with partial agonistic activity. The aminopeptide sequence for saralasin differs from angiotensin II at three sites: * At position 1, sarcosine replaces aspartic acid, thereby increasing the affinity for vascular smooth muscle AT II receptors and making sara resistant to degradation by aminopeptidases. * At position 5, isoleucine is replaced by valine * At position 8, phenylalanine is replaced by alanine which leads to a smaller stimulatory effect. Saralasin was used to distinguish renovascular hypertension Renovascular hypertension is a condition in which high blood pressure is caused by the kidneys' hormonal response to narrowing of the renal arteries, arteries supplying the kidneys. When functioning properly this hormonal axis regulates blood pres ... from essential hypertension before its discontinuation in January 1984 because of many false-positive and false-negative reports.Hutchison and Shahan (2004) Referenc ...
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