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Rs6295
rs6295, also called C(-1019)G, is a gene variation—a single nucleotide polymorphism (SNP)—in the HTR1A gene. It is one of the most investigated SNPs of its gene. The C-allele is the most prevalent with 0.675 against the G-allele with 0.325 among Caucasian. The effect of the SNP on the binding potential of the human 5-HT1A neuroreceptor has been assessed with positron emission tomography and the WAY-100635 radioligand, with a study reporting no apparent influence from the SNP. Disorders The SNP has been investigated for association with suicide attempts, and psychiatric disorders. One study found an association of the variant with schizophrenia. Some studies associate the G-allele or GG-genotype with depression. Not all studies show associations between the disorder and the G-allele. In one study of premenstrual dysphoric disorder C/C was found as the high-risk genotype. Several studies have examine the SNP association with medical treatment response, e.g., antidepressant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single Nucleotide Polymorphism
In genetics and bioinformatics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold. For example, a G nucleotide present at a specific location in a reference genome may be replaced by an A in a minority of individuals. The two possible nucleotide variations of this SNP – G or A – are called alleles. SNPs can help explain differences in susceptibility to a wide range of diseases across a population. For example, a common SNP in the CFH gene is associated with increased risk of age-related macular degeneration. Differences in the severity of an illness or response to treatments may also be manifestations of genetic variations caused by SNPs. For example, two common SNPs in the ''A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Depression
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, the term was adopted by the American Psychiatric Association for this symptom cluster under mood disorders in the 1980 version of the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM-III), and has become widely used since. The disorder causes the second-most years lived with disability, after lower back pain. The diagnosis of major depressive disorder is based on the person's reported experiences, behavior reported by family or friends, and a mental status examination. There is no laboratory test for the disorder, but testing may be done to rule out physical conditions that can cause similar symptoms. The most common time of onset is in a person's 20s, with females affec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mood Disorder
A mood disorder, also known as an affective disorder, is any of a group of conditions of mental and behavioral disorder where the main underlying characteristic is a disturbance in the person's mood. The classification is in the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM) and International Classification of Diseases (ICD). Mood disorders fall into seven groups, including; abnormally elevated mood, such as mania or hypomania; depressed mood, of which the best-known and most researched is major depressive disorder (MDD) (alternatively known as clinical depression, unipolar depression, or major depression); and moods which cycle between mania and depression, known as bipolar disorder (BD) (formerly known as manic depression). There are several subtypes of depressive disorders or psychiatric syndromes featuring less severe symptoms such as dysthymic disorder (similar to MDD, but longer lasting and more persistent, though often milder) and cyclothymic disorde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self-transcendence
Self-transcendence is a personality trait that involves the expansion or evaporation of personal boundaries. This may potentially include spiritual experiences such as considering oneself an integral part of the universe. Several psychologists, including Viktor Frankl, Abraham Maslow, and Pamela G. Reed have made contributions to the theory of self-transcendence. Self-transcendence is distinctive as the first trait-concept of a spiritual nature to be incorporated into a major theory of personality. It is one of the "character" dimensions of personality assessed in Cloninger's Temperament and Character Inventory. It is also assessed by the Self-Transcendence Scale and the Adult Self-Transcendence Inventory. Nature of the trait Several overlapping definitions of self-transcendence have been given. Viktor Frankl wrote, "The essentially self-transcendent quality of human existence renders man ''a being reaching out beyond himself''." According to Reed, self-transcendence is: th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Temperament And Character Inventory
The Temperament and Character Inventory (TCI) is an inventory for personality traits devised by Cloninger et al. It is closely related to and an outgrowth of the Tridimensional Personality Questionnaire (TPQ), and it has also been related to the dimensions of personality in Zuckerman's alternative five and Eysenck's models and those of the five factor model. TCI operates with seven dimensions of personality traits: four so-called ''temperaments'' * Novelty seeking (NS) * Harm avoidance (HA) * Reward dependence (RD) * Persistence (PS) and three so-called ''characters'' * Self-directedness (SD) * Cooperativeness (CO) * Self-transcendence (ST) Each of these traits has a varying number of subscales. The dimensions are determined from a 240-item questionnaire. The TCI is based on a psychobiological model that attempts to explain the underlying causes of individual differences in personality traits. Versions Originally developed in English, TCI has been translated to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Neural Transmission
The ''Journal of Neural Transmission'' is a monthly peer-reviewed medical journal covering clinical neurology and translational neuroscience. It was established in 1950 by Carmen Coronini and Alexander Sturm as ''Acta Neurovegetativa''. It was renamed to the ''Journal of Neuro-Visceral Relations'' in 1968 and to its current title in 1972. From 1989 to 1995, the journal was published in two sections: a "general section" and a "Parkinson's disease and dementia section." The editor-in-chief is Peter Riederer. According to the ''Journal Citation Reports'', the journal has a 2019 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 3.505. References External links * Neurology journals Academic journals established in 1950 Monthly journals Springer Science+Business Med ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harm Avoidance
Harm avoidance (HA) is a personality trait characterized by excessive worrying; pessimism; shyness; and being fearful, doubtful, and easily fatigued. In MRI studies HA was correlated with reduced grey matter volume in the orbito-frontal, occipital and parietal regions. Harm avoidance is a temperament assessed in the Temperament and Character Inventory (TCI), its revised version (TCI-R) and the Tridimensional Personality Questionnaire (TPQ) and is positively related to the trait neuroticism and inversely to extraversion in the Revised NEO Personality Inventory and the Eysenck Personality Questionnaire. Researchers have contended that harm avoidance represents a composite personality dimension with neurotic introversion at one end of the spectrum and stable extraversion at the other end. Harm avoidance has also been found to have moderate inverse relationships with conscientiousness and openness to experience in the five factor model In personality psychology and psychometrics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tridimensional Personality Questionnaire
Tridimensional Personality Questionnaire (TPQ) is a personality test. It was devised by C. Robert Cloninger. A newer version of the questionnaire is called Temperament and Character Inventory. As the name indicates TPQ seeks to measure three dimensions (traits) of the personality. These personality traits are novelty seeking, harm avoidance and reward dependence. Each have four subscales. There are 100 true-false questions which form the basis for the computation of the traits. The personality test also exists in Chinese, French and German versions. Neurobiology Cloninger suggested that the three dimensions, novelty seeking, harm avoidance, and reward dependence, were correlated with low basal dopaminergic activity, high serotonergic activity, and low basal noradrenergic activity, respectively. Much research has gone into examining these links, e.g., with personality genetics. References Other * {{Cite journal , author = C. R. Cloninger , title = A systematic met ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroticism
Neuroticism is a personality trait associated with negative emotions. It is one of the Big Five traits. Individuals with high scores on neuroticism are more likely than average to experience such feelings as anxiety, worry, fear, anger, shame, frustration, envy, jealousy, pessimism, guilt, depressed mood, and loneliness. Such people are thought to respond worse to stressors and are more likely to interpret ordinary situations, such as minor frustrations, as appearing hopelessly difficult. Their behavioral responses may include procrastination, substance use, and other maladaptive behaviors, which may temporarily aid in relieving negative emotions and in generating positive ones. People with high scores on the neuroticism index are thought to be at risk of developing common mental disorders ( mood disorders, anxiety disorders, and substance use disorders have been studied), and the sorts of symptoms once referred to as " neuroses". Individuals who score low in neu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NEO PI-R
The Revised NEO Personality Inventory (NEO PI-R) is a personality inventory that assesses an individual on five dimensions of personality. These are the same dimensions found in the Big Five personality traits. These traits are openness to experience, conscientiousness, extraversion (-introversion), agreeableness, and neuroticism. In addition, the NEO PI-R also reports on six subcategories of each Big Five personality trait (called facets). Historically, development of the Revised NEO PI-R began in 1978 when Paul Costa and Robert McCrae published a personality inventory. The researchers later published three updated versions of their personality inventory in 1985, 1992, and 2005. These were called the NEO PI (Neuroticism, Extraversion, Openness Personality Inventory), NEO PI-R (or Revised NEO PI), and NEO PI-3, respectively. The revised inventories feature updated vocabulary that could be understood by adults of any education level, as well as children. The inventories have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Personality Trait
In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality. Trait theorists are primarily interested in the measurement of ''traits'', which can be defined as habitual patterns of behavior, thought, and emotion. According to this perspective, traits are aspects of personality that are relatively stable over time, differ across individuals (e.g. some people are outgoing whereas others are not), are relatively consistent over situations, and influence behaviour. Traits are in contrast to states, which are more transitory dispositions. Traits such as extraversion vs. introversion are measured on a spectrum, with each person placed somewhere along it. Trait theory suggests that some natural behaviours may give someone an advantage in a position of leadership. There are two approaches to define traits: as internal causal properties or as purely descriptive summaries. The internal causal definition states that traits influence our be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antidepressant
Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction. Common side effects of antidepressants include Xerostomia, dry mouth, weight gain, dizziness, headaches, akathisia, sexual dysfunction, and emotional blunting. There is an increased risk of Suicidal ideation, suicidal thinking and Suicide, behavior when taken by children, adolescents, and young adults. Antidepressant discontinuation syndrome, Discontinuation syndrome, which resembles recurrent Depression (mood), depression in the case of the Selective serotonin reuptake inhibitor, SSRI class, may occur after stopping the intake of any antidepressant. Research regarding the effectiveness of antidepressants for depression in adults is controversial and has found both benefits and drawbacks. Meanwhile, evidence of benefit in children and adolescents is unclear, even though antidepressant use has considerably increased in children and adolescents in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
