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Rodiasine
Rodiasine is a cyclic bisbenzylisoquinoline alkaloid that was first isolated from the South American greenheart tree '' Chlorocardium rodiei''. The synthesis of ''O''-demethylrodiasine (antioquine) and its derivatives, and the possible application of these compounds as anti-cancer, calcium channel blockers Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium () through calcium channels. Calcium channel blockers are used as antihypertensive drugs, i.e., as ..., and anti-parasitic drugs has been described. References Benzylisoquinoline alkaloids {{alkaloid-stub ...
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Chlorocardium Rodiei
''Chlorocardium rodiei'' (greenheart) is a species of flowering plant in the family Lauraceae. It is one of two species in the genus ''Chlorocardium''. It is native to Guyana and Suriname in South America. Other common names include cogwood, demerara greenheart, greenhart, ''ispingo moena'', ''sipiri'', ''bebeeru'' and ''bibiru''. It is an evergreen tree growing 15 to 30 m tall with a trunk diameter of 35 to 60 cm. The leaves are oppositely arranged and simple with smooth edges. The fruit is a drupe containing a single seed. The cyclic bisbenzylisoquinoline alkaloid rodiasine was first isolated from this species. The wood is extremely hard and strong, so hard that it cannot be worked with standard tools. It is durable in marine conditions, so it is used to build docks and other structures, and it was an early choice for fly fishing rods. An estimated 15 to 28% of the original population has been harvested. The species' use as a commercial timber began in the late 18th cent ...
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Bisbenzylisoquinolinium
Isoquinoline is a heterocyclic aromatic organic compound. It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. Properties Isoquinoline is a colorless hygroscopic liquid at temperatures above its melting point with a penetrating, unpleasant odor. Impure samples can appear brownish, as is typical for nitrogen heterocycles. It crystallizes in platelets that have a low solubility in water but dissolve well in ethanol, acetone, diethyl ether, carbon disulfide, and other common organic solvents. It is also soluble in dilute acids as the protonated derivative. Being an analog of pyrid ...
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Alkaloid
Alkaloids are a class of basic BASIC (Beginners' All-purpose Symbolic Instruction Code) is a family of general-purpose, high-level programming languages designed for ease of use. The original version was created by John G. Kemeny and Thomas E. Kurtz at Dartmouth College ..., natural product, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms includi ...
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Calcium Channel Blocker
Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium () through calcium channels. Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension. CCBs are particularly effective against large vessel stiffness, one of the common causes of elevated systolic blood pressure in elderly patients. Calcium channel blockers are also frequently used to alter heart rate (especially from atrial fibrillation), to prevent peripheral and cerebral vasospasm, and to reduce chest pain caused by angina pectoris. N-type, L-type, and T-type voltage-dependent calcium channels are present in the zona glomerulosa of the human adrenal gland, and CCBs can directly influence the biosynthesis of aldosterone in adrenocortical cells, with consequent impact on the clinical treatment of hypertension with these agents. CCBs have been shown ...
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Antiparasitic Drugs
Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases, such as those caused by helminths, amoeba, ectoparasites, parasitic fungi, and protozoa, among others. Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth; they are usually effective against a limited number of parasites within a particular class. Antiparasitics are one of the antimicrobial drugs which include antibiotics that target bacteria, and antifungals that target fungi. They may be administered orally, intravenously or topically. Broad-Spectrum antiparasitics, analogous to broad-spectrum antibiotics for bacteria, are antiparasitic drugs with efficacy in treating a wide range of parasitic infections caused by parasites from different classes. Types Broad-spectrum * Nitazoxanide Antiprotozoals * Melarsoprol (for treatment of sleeping sickness caused by '' Trypanosoma brucei'') * Eflornithine (for sle ...
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