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Retrograde Amnesia
In neurology, retrograde amnesia (RA) is the inability to access memories or information from before an injury or disease occurred. RA differs from a similar condition called anterograde amnesia (AA), which is the inability to form new memories following injury or disease onset. Although an individual can have both RA and AA at the same time, RA can also occur on its own; this 'pure' form of RA can be further divided into three types: focal, isolated, and pure RA. RA negatively affects an individual's Episodic memory, episodic, Autobiographical memory, autobiographical, and declarative memory, but they can still form new memories because RA leaves procedural memory intact. Depending on its severity, RA can result in either temporally graded or more permanent memory loss. However, memory loss usually follows Ribot's law, which states that individuals are more likely to lose recent memories than older memories. Diagnosing RA generally requires using an Autobiographical Memory Intervi ...
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Neurology
Neurology (from , "string, nerve" and the suffix wikt:-logia, -logia, "study of") is the branch of specialty (medicine) , medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the nervous system, which comprises the Human brain, brain, the spinal cord and the peripheral nervous system , peripheral nerves. Neurological practice relies heavily on the field of neuroscience, the scientific study of the nervous system, using various techniques of neurotherapy. IEEE Brain (2019). "Neurotherapy: Treating Disorders by Retraining the Brain". ''The Future Neural Therapeutics White Paper''. Retrieved 23.01.2025 from: https://brain.ieee.org/topics/neurotherapy-treating-disorders-by-retraining-the-brain/#:~:text=Neurotherapy%20trains%20a%20patient's%20brain,wave%20activity%20through%20positive%20reinforcement International Neuromodulation Society, Retrieved 23 January 2025 from: https://www.neuromodulation.com/ Val Danilov I (2023). "The O ...
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Psychogenic Disease
A psychogenic effect is one that originates from the brain instead of other physical organs (i.e. the cause is psychological Psychology is the scientific study of mind and behavior. Its subject matter includes the behavior of humans and nonhumans, both consciousness, conscious and Unconscious mind, unconscious phenomena, and mental processes such as thoughts, feel ... rather than physiological) and may refer to: * Psychogenic pain * Psychogenic disease * Psychogenic amnesia *Psychogenic cough, i.e. a habit cough * Mass psychogenic illness {{disambiguation ...
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Thiamine
Thiamine, also known as thiamin and vitamin B1, is a vitamin – an Nutrient#Micronutrients, essential micronutrient for humans and animals. It is found in food and commercially synthesized to be a dietary supplement or medication. Phosphorylated forms of thiamine are required for some Metabolism, metabolic reactions, including the breakdown of Carbohydrate metabolism, glucose and amino acids. Food sources of thiamine include whole grains, legumes, and some meats and fish. Refined grain, Grain processing removes much of the vitamin content, so in many countries cereals and flours are food fortification, enriched with thiamine. Supplements and medications are available to treat and prevent thiamine deficiency and the disorders that result from it such as Thiamine deficiency#Dry beriberi, beriberi and Wernicke encephalopathy. They are also used to treat maple syrup urine disease and Leigh syndrome. Supplements and medications are typically taken Route of administration#Oral ...
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Amygdala
The amygdala (; : amygdalae or amygdalas; also '; Latin from Greek language, Greek, , ', 'almond', 'tonsil') is a paired nucleus (neuroanatomy), nuclear complex present in the Cerebral hemisphere, cerebral hemispheres of vertebrates. It is considered part of the limbic system. In Primate, primates, it is located lateral and medial, medially within the temporal lobes. It consists of many nuclei, each made up of further subnuclei. The subdivision most commonly made is into the Basolateral amygdala, basolateral, Central nucleus of the amygdala, central, cortical, and medial nuclei together with the intercalated cells of the amygdala, intercalated cell clusters. The amygdala has a primary role in the processing of memory, decision making, decision-making, and emotions, emotional responses (including fear, anxiety, and aggression). The amygdala was first identified and named by Karl Friedrich Burdach in 1822. Structure Thirteen Nucleus (neuroanatomy), nuclei have been identif ...
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Long-term Potentiation
In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons. The opposite of LTP is long-term depression, which produces a long-lasting decrease in synaptic strength. It is one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength. As memories are thought to be encoded by modification of synaptic strength, LTP is widely considered one of the major cellular mechanisms that underlies learning and memory. LTP was discovered in the rabbit hippocampus by Terje Lømo in 1966 and has remained a popular subject of research since. Many modern LTP studies seek to better understand its basic biology, while others aim to draw a causal link between LTP and behavioral learning. Still, others try to develop methods, pharmacologic or otherwise, of enhanci ...
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Psychogenic Fugue
Dissociative fugue ( ), previously referred to as a fugue state or psychogenic fugue,Dissociative Fugue (formerly Psychogenic Fugue) 'DSM-IV 300.13, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition'' is a rare psychiatric condition characterized by reversible amnesia regarding one’s identity, often accompanied by unexpected travel or wandering. In some cases, individuals may assume a new identity and be unable to recall personal information from before the onset of symptoms. It is classified as a mental and behavioral disorderDrs; and is variously categorized as a dissociative disorder, a conversion disorder, or a somatic symptom disorder. According to the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM-5), dissociative fugue is a subset of dissociative amnesia. Recovery from a fugue state typically results in the restoration of prior memories, and additional treatment is generally unnecessary. Episodes are not considered dissociative fugue ...
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Psychogenic Amnesia
Dissociative amnesia or psychogenic amnesia is a dissociative disorder "characterized by retrospectively reported memory gaps. These gaps involve an inability to recall personal information, usually of a traumatic or stressful nature." The concept is scientifically controversial and remains disputed. Dissociative amnesia was previously known as psychogenic amnesia, a memory disorder, which was characterized by sudden retrograde episodic memory loss, said to occur for a period of time ranging from hours to years to decades. The atypical clinical syndrome of the memory disorder (as opposed to organic amnesia) is that a person with psychogenic amnesia is profoundly unable to remember personal information about themselves; there is a lack of conscious self-knowledge which affects even simple self-knowledge, such as who they are. Psychogenic amnesia is distinguished from organic amnesia in that it is supposed to result from a nonorganic cause: no structural brain damage should be ...
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Shaken Baby Syndrome
Shaken baby syndrome (SBS), also known as abusive head trauma (AHT), is a controversial and scientifically disputed medical condition in children younger than five years old, hypothesized to be caused by blunt trauma, vigorous shaking, or a combination of both. According to literature, the condition is caused by violent shaking with or without blunt impact that can lead to long-term health consequences for infants or children. Diagnosis can be difficult, but is generally characterized by the "triad" of findings: retinal hemorrhage, encephalopathy, and subdural hematoma. A CT scan of the head is typically recommended if a concern is present. If there are concerning findings on the CT scan, a full work-up for child abuse often occurs, including an eye exam and skeletal survey. Retinal hemorrhage is highly associated with AHT, occurring in 78% of cases of AHT versus 5% of cases of non-abusive head trauma, although such findings rely on contested methodology. A 2023 review concl ...
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Diffuse Axonal Injury
Diffuse axonal injury (DAI) is a brain injury in which scattered lesions occur over a widespread area in white matter tracts as well as grey matter. DAI is one of the most common and devastating types of traumatic brain injury and is a major cause of unconsciousness and persistent vegetative state after severe head trauma.Wasserman J. and Koenigsberg R.A. (2007)Diffuse axonal injury Emedicine.com. Retrieved on 2008-01-26. It occurs in about half of all cases of severe head trauma and may be the primary damage that occurs in concussion. The outcome is frequently coma, with over 90% of patients with severe DAI never regaining consciousness. Those who awaken from the coma often remain significantly impaired.Vinas F.C. and Pilitsis J. (2006)Penetrating head trauma Emedicine.com. Retrieved on 2008-01-14. DAI can occur across the spectrum of traumatic brain injury (TBI) severity, wherein the burden of injury increases from mild to severe. Concussion may be a milder type of diffuse ...
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Perirhinal
The perirhinal cortex is a cortical region in the medial temporal lobe that is made up of Brodmann areas 35 and 36. It receives highly processed sensory information from all sensory regions, and is generally accepted to be an important region for memory. It is bordered caudally by postrhinal cortex or parahippocampal cortex (homologous regions in rodents and primates, respectively) and ventrally and medially by entorhinal cortex. Structure The perirhinal cortex is composed of two regions: areas 36 and 35. Area 36 is sometimes divided into three subdivisions: 36d is the most rostral and dorsal, 36r ventral and caudal, and 36c the most caudal. Area 35 can be divided in the same manner, into 35d and 35v (for dorsal and ventral, respectively). Area 36 is six-layered, dysgranular, meaning that its layer IV is relatively sparse. Area 35 is agranular cortex (lacking any cells in layer IV). Function The perirhinal cortex is involved in both visual perception and memory; it faci ...
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Entorhinal
The entorhinal cortex (EC) is an area of the brain's allocortex, located in the medial temporal lobe, whose functions include being a widespread network hub for memory, navigation, and the perception of time.Integrating time from experience in the lateral entorhinal cortex Albert Tsao, Jørgen Sugar, Li Lu, Cheng Wang, James J. Knierim, May-Britt Moser & Edvard I. Moser Naturevolume 561, pages57–62 (2018) The EC is the main interface between the hippocampus and neocortex. The EC-hippocampus system plays an important role in declarative (autobiographical/episodic/semantic) memories and in particular spatial memories including memory formation, memory consolidation, and memory optimization in sleep. The EC is also responsible for the pre-processing (familiarity) of the input signals in the reflex nictitating membrane response of classical trace conditioning; the association of impulses from the eye and the ear occurs in the entorhinal cortex. Anatomy The entorhinal co ...
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