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Receptor–ligand Kinetics
In biochemistry, receptor–ligand kinetics is a branch of chemical kinetics in which the kinetic species are defined by different non-covalent bindings and/or conformations of the molecules involved, which are denoted as '' receptor(s)'' and '' ligand(s)''. Receptor–ligand binding kinetics also involves the on- and off-rates of binding. A main goal of receptor–ligand kinetics is to determine the concentrations of the various kinetic species (i.e., the states of the receptor and ligand) at all times, from a given set of initial concentrations and a given set of rate constants. In a few cases, an analytical solution of the rate equations may be determined, but this is relatively rare. However, most rate equations can be integrated numerically, or approximately, using the steady-state approximation. A less ambitious goal is to determine the final ''equilibrium'' concentrations of the kinetic species, which is adequate for the interpretation of equilibrium binding data. A con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemistry
Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines. Almost all List of life sciences, areas of the life sciences are being uncovered and developed through biochemical methodology and research.#Voet, Voet (2005), p. 3. Biochemistry focuses on understanding the chemical basis that allows biomolecule, biological molecules to give rise to the processes that occur within living Cell (biology), cells and between cells,#Karp, Karp (2009), p. 2. in turn relating greatly to the understanding of tissue (biology), tissues and organ (anatomy), organs as well as organism structure and function.#Miller, Miller (2012). p. 62. Biochemistry is closely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Separation Of Variables
In mathematics, separation of variables (also known as the Fourier method) is any of several methods for solving ordinary differential equation, ordinary and partial differential equations, in which algebra allows one to rewrite an equation so that each of two variables occurs on a different side of the equation. Ordinary differential equations (ODE) A differential equation for the unknown f(x) is separable if it can be written in the form :\frac f(x) = g(x)h(f(x)) where g and h are given functions. This is perhaps more transparent when written using y = f(x) as: :\frac=g(x)h(y). So now as long as ''h''(''y'') ≠ 0, we can rearrange terms to obtain: : = g(x) \, dx, where the two variables ''x'' and ''y'' have been separated. Note ''dx'' (and ''dy'') can be viewed, at a simple level, as just a convenient notation, which provides a handy mnemonic aid for assisting with manipulations. A formal definition of ''dx'' as a differential (infinitesimal) is somewhat advanced. Al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford University Press
Oxford University Press (OUP) is the publishing house of the University of Oxford. It is the largest university press in the world. Its first book was printed in Oxford in 1478, with the Press officially granted the legal right to print books by decree in 1586. It is the second-oldest university press after Cambridge University Press, which was founded in 1534. It is a department of the University of Oxford. It is governed by a group of 15 academics, the Delegates of the Press, appointed by the Vice Chancellor, vice-chancellor of the University of Oxford. The Delegates of the Press are led by the Secretary to the Delegates, who serves as OUP's chief executive and as its major representative on other university bodies. Oxford University Press has had a similar governance structure since the 17th century. The press is located on Walton Street, Oxford, Walton Street, Oxford, opposite Somerville College, Oxford, Somerville College, in the inner suburb of Jericho, Oxford, Jericho. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scatchard Plot
The Scatchard equation is an equation used in molecular biology to calculate the affinity and number of binding sites of a receptor for a ligand. It is named after the American chemist George Scatchard. Equation Throughout this article, 'RL''denotes the concentration of a receptor-ligand complex, 'R''the concentration of free receptor, and 'L''the concentration of free ligand (so that the total concentration of the receptor and ligand are 'R'' 'RL''and 'L'' 'RL'' respectively). Let ''n'' be the number of binding sites for ligand on each receptor molecule, and let represent the average number of ligands bound to a receptor. Let ''Kd'' denote the dissociation constant between the ligand and receptor. The Scatchard equation is given by :\frac = \frac - \frac By plotting / 'L''versus , the Scatchard plot shows that the slope equals to -1/''Kd'' while the x-intercept equals the number of ligand binding sites ''n''. Derivation ''n''=1 Ligand When each receptor has a single liga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patlak Plot
A Patlak plot (sometimes called Gjedde–Patlak plot, Patlak–Rutland plot, or Patlak analysis) is a graphical analysis technique based on the compartment model that uses linear regression to identify and analyze pharmacokinetics of tracers involving irreversible uptake, such as in the case of deoxyglucose. It is used for the evaluation of nuclear medicine imaging data after the injection of a radioopaque or radioactive tracer. The method is model-independent because it does not depend on any specific compartmental model configuration for the tracer, and the minimal assumption is that the behavior of the tracer can be approximated by two compartments – a "central" (or reversible) compartment that is in rapid equilibrium with plasma, and a "peripheral" (or irreversible) compartment, where tracer enters without ever leaving during the time of the measurements. The amount of tracer in the region of interest is accumulating according to the equation: : R(t) = K \int_0^t C_p(\ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Binding Potential
In pharmacokinetics and receptor-ligand kinetics the binding potential (BP) is a combined measure of the density of "available" neuroreceptors and the Affinity (pharmacology), affinity of a drug to that neuroreceptor. Description Consider a ligand receptor binding system. Ligand with a concentration ''L'' associates with a receptor of concentration or availability ''R'' to form a ligand-receptor complex with concentration ''RL''. The binding potential is then the ratio ligand-receptor complex to free ligand at equilibrium and in the limit of L tending to 0, and is given symbol BP: BP=\frac\bigg, _ This quantity, originally defined by Mintun, describes the capacity of a receptor to bind ligand. It is a limit (L << Ki) of the general receptor association equation: and is thus also equivalent to: These equations apply equally when measuring the total receptor density or the residual receptor density available after binding to second li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ordinary Differential Equation
In mathematics, an ordinary differential equation (ODE) is a differential equation (DE) dependent on only a single independent variable (mathematics), variable. As with any other DE, its unknown(s) consists of one (or more) Function (mathematics), function(s) and involves the derivatives of those functions. The term "ordinary" is used in contrast with partial differential equation, ''partial'' differential equations (PDEs) which may be with respect to one independent variable, and, less commonly, in contrast with stochastic differential equations, ''stochastic'' differential equations (SDEs) where the progression is random. Differential equations A linear differential equation is a differential equation that is defined by a linear polynomial in the unknown function and its derivatives, that is an equation of the form :a_0(x)y +a_1(x)y' + a_2(x)y'' +\cdots +a_n(x)y^+b(x)=0, where a_0(x),\ldots,a_n(x) and b(x) are arbitrary differentiable functions that do not need to be linea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Fraction
In algebra, the partial fraction decomposition or partial fraction expansion of a rational fraction (that is, a fraction such that the numerator and the denominator are both polynomials) is an operation that consists of expressing the fraction as a sum of a polynomial (possibly zero) and one or several fractions with a simpler denominator. The importance of the partial fraction decomposition lies in the fact that it provides algorithms for various computations with rational functions, including the explicit computation of antiderivatives, Taylor series expansions, inverse Z-transforms, and inverse Laplace transforms. The concept was discovered independently in 1702 by both Johann Bernoulli and Gottfried Leibniz. In symbols, the ''partial fraction decomposition'' of a rational fraction of the form \frac, where and are polynomials, is the expression of the rational fraction as \frac=p(x) + \sum_j \frac where is a polynomial, and, for each , the denominator is a power ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quadratic Formula
In elementary algebra, the quadratic formula is a closed-form expression describing the solutions of a quadratic equation. Other ways of solving quadratic equations, such as completing the square, yield the same solutions. Given a general quadratic equation of the form , with representing an unknown, and coefficients , , and representing known real number, real or complex number, complex numbers with , the values of satisfying the equation, called the Zero of a function, ''roots'' or ''zeros'', can be found using the quadratic formula, x = \frac, where the plus–minus sign, plus–minus symbol "" indicates that the equation has two roots. Written separately, these are: x_1 = \frac, \qquad x_2 = \frac. The quantity is known as the discriminant of the quadratic equation. If the coefficients , , and are real numbers then when , the equation has two distinct real number, real roots; when , the equation has one repeated root, repeated real root; and when , the equation h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Kinetics
Chemical kinetics, also known as reaction kinetics, is the branch of physical chemistry that is concerned with understanding the rates of chemical reactions. It is different from chemical thermodynamics, which deals with the direction in which a reaction occurs but in itself tells nothing about its rate. Chemical kinetics includes investigations of how experimental conditions influence the speed of a chemical reaction and yield information about the reaction's mechanism and transition states, as well as the construction of mathematical models that also can describe the characteristics of a chemical reaction. History The pioneering work of chemical kinetics was done by German chemist Ludwig Wilhelmy in 1850. He experimentally studied the rate of inversion of sucrose and he used integrated rate law for the determination of the reaction kinetics of this reaction. His work was noticed 34 years later by Wilhelm Ostwald. In 1864, Peter Waage and Cato Guldberg published the law ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rate Constant
In chemical kinetics, a reaction rate constant or reaction rate coefficient () is a proportionality constant which quantifies the rate and direction of a chemical reaction by relating it with the concentration of reactants. For a reaction between reactants A and B to form a product C, where :A and B are reactants :C is a product :''a'', ''b'', and ''c'' are stoichiometric coefficients, the reaction rate is often found to have the form: r = k mathrmm mathrm Here is the reaction rate constant that depends on temperature, and and are the molar concentrations of substances A and B in moles per unit volume of solution, assuming the reaction is taking place throughout the volume of the solution. (For a reaction taking place at a boundary, one would use moles of A or B per unit area instead.) The exponents ''m'' and ''n'' are called partial orders of reaction and are ''not'' generally equal to the stoichiometric coefficients ''a'' and ''b''. Instead they depend on the reactio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Equilibrium Constant
The equilibrium constant of a chemical reaction is the value of its reaction quotient at chemical equilibrium, a state approached by a dynamic chemical system after sufficient time has elapsed at which its composition has no measurable tendency towards further change. For a given set of reaction conditions, the equilibrium constant is independent of the initial analytical concentrations of the reactant and product species in the mixture. Thus, given the initial composition of a system, known equilibrium constant values can be used to determine the Chemical equilibrium#Composition of a mixture, composition of the system at equilibrium. However, reaction parameters like temperature, solvent, and ionic strength may all influence the value of the equilibrium constant. A knowledge of equilibrium constants is essential for the understanding of many chemical systems, as well as the biochemical processes such as oxygen transport by hemoglobin in blood and acid–base homeostasis in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
