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Quillaia
Quillaia is the milled inner Bark (botany), bark or small stems and branches of the soapbark (''Quillaja saponaria''). Other names include ''Murillo bark extract'', ''Panama bark extract'', ''Quillaia extract'', ''Quillay bark extract'', ''Soapbark extract'', and . Quillaia contains high concentrations of saponins that can be increased further by processing. Highly purified saponins from quillaia bark are used as Immunologic adjuvant, adjuvants to enhance the effectiveness of vaccines. Other compounds in the crude extract include tannins and other polyphenols, and calcium oxalate.EFSA Panel on Food Additives and Flavourings (FAF) et alRe-evaluation of Quillaia extract (E 999) as a food additive and safety of the proposed extension of use. EFSA Journal. 6 March 2019. Quillaia is used in the manufacture of food additives. The extract also is used as a humectant in baked goods, frozen dairy products, and puddings and as a foaming agent in soft drinks. It is used in agriculture for s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunologic Adjuvant
In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. The word "adjuvant" comes from the Latin word , meaning to help or aid. "An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens." In the early days of vaccine manufacture, significant variations in the efficacy of different batches of the same vaccine were correctly assumed to be caused by contamination of the reaction vessels. However, it was soon found that more scrupulous cleaning actually seemed to ''reduce'' the effectiveness of the vaccines, and some contaminants actually enhanced the immune response. There are many known adjuvants in widespread use, including potassium alum, various plant and animal derived oils and virosomes. Overview Adjuvants in immunology are often used to modify or augment the effects of a vaccine by stimulating the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quillaja Saponaria
''Quillaja saponaria'', the soap bark tree or soapbark, is an evergreen tree in the family Quillajaceae, native to warm temperate central Chile. In Chile it occurs from 32nd parallel south, 32 to 40th parallel south, 40° South Latitude approximately and at up to 2000 m (6500 ft) above sea level. It can grow to 15–20 m (50–65 ft) in height. The tree has thick, dark bark; smooth, leathery, shiny, oval evergreen Leaf, leaves 3–5 cm long; white star-shaped flowers 15 mm diameter borne in dense corymbs; and a dry fruit with five follicles each containing 10–20 seeds. The tree has several practical and commercial uses. Habitat This tree occurs at elevations up to 2000 metres. The species is drought resistant, and tolerates about −12 °C (10 °F) in its natural habitat. Examples of specific occurrences are in central Chile in the forests of La Campana National Park and Cerro La Campana, in which locales it is associated with the Chilean win ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Soapbark
''Quillaja saponaria'', the soap bark tree or soapbark, is an evergreen tree in the family Quillajaceae, native to warm temperate central Chile. In Chile it occurs from 32 to 40° South Latitude approximately and at up to 2000 m (6500 ft) above sea level. It can grow to 15–20 m (50–65 ft) in height. The tree has thick, dark bark; smooth, leathery, shiny, oval evergreen leaves 3–5 cm long; white star-shaped flowers 15 mm diameter borne in dense corymbs; and a dry fruit with five follicles each containing 10–20 seeds. The tree has several practical and commercial uses. Habitat This tree occurs at elevations up to 2000 metres. The species is drought resistant, and tolerates about −12 °C (10 °F) in its natural habitat. Examples of specific occurrences are in central Chile in the forests of La Campana National Park and Cerro La Campana, in which locales it is associated with the Chilean wine palm, ''Jubaea chilensis''. It is often us ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saponin
Saponins (Latin ''sapon'', 'soap' + ''-in'', 'one of') are bitter-tasting, usually toxic plant-derived secondary metabolites. They are organic chemicals that become foamy when agitated in water and have high molecular weight. They are present in a wide range of plant species throughout the bark, leaves, stems, roots and flowers but particularly in soapwort (genus '' Saponaria''), a flowering plant, the soapbark tree ('' Quillaja saponaria''), common corn-cockle ('' Agrostemma githago'' L.), baby's breath ( ''Gypsophila'' spp.) and soybeans ('' Glycine max'' L.). They are used in soaps, medicines (e.g. drug adjuvants), fire extinguishers, dietary supplements, steroid synthesis, and in carbonated beverages (for example, being responsible for maintaining the head on root beer). Saponins are both water and fat soluble, which gives them their useful soap properties. Some examples of these chemicals are glycyrrhizin ( licorice flavoring) and quillaia (alt. quillaja), a bark ext ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
QS21
QS-21 is a purified plant extract used as a vaccine adjuvant. It is derived from the soap bark tree (''Quillaja saponaria''), which is native to the countries of Chile, Peru, and Bolivia. The crude drug (''Quillajae cortex'', Quillaia) is imported from Peru and Chile. The extract contains water-soluble triterpene glycosides, which are members of a family of plant-based compounds called saponins. It has been tested as an adjuvant in various vaccines in attempts to improve their efficacy. It is believed to enhance both humoral and cell-mediated immunity. Use QS-21 has been clinically evaluated as a vaccine adjuvant. , it had been tested in more than 3000 patients in 60 clinical trials. Direct, unencapsuled QS-21 is very liable to hydrolysis. It also causes immediate pain at injection site and ''in vitro'' causes hemolysis. All of these can be prevented by packaging QS-21 into lipid-based particles, which also have the added advantage of targeting its delivery to phagocytes. I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humectant
A humectant is a hygroscopic (water-absorbing) substance used to keep things moist. They are used in many products, including food, cosmetics, medicines and pesticides. When used as a food additive, a humectant has the effect of keeping moisture in the food. Humectants are sometimes used as a component of antistatic coatings for plastics. A humectant attracts and retains the moisture in the air nearby via absorption, drawing the water vapor into or beneath the organism's or object's surface. This is the opposite use of a hygroscopic material where it is used as a desiccant used to draw moisture away. In pharmaceuticals and cosmetics, humectants can be used in topical dosage forms to increase the solubility of a chemical compound's active ingredients, increasing the active ingredients' ability to penetrate skin, or its activity time. This hydrating property can also be needed to counteract a dehydrating active ingredient (e.g., soaps, corticoids, and some alcohols), which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bottles Of Quillaja Extract
A bottle is a narrow-necked container made of an impermeable material (such as glass, plastic or aluminium) in various shapes and sizes that stores and transports liquids. Its mouth, at the bottling line, can be sealed with an internal stopper, an external bottle cap, a closure, or induction sealing. Etymology First attested in 14th century. From the English word ''bottle'' derives from an Old French word ''boteille'', from vulgar Latin">-4; we might wonder whether there's a point at which it's appropriate to talk of the beginnings of French, that is, when it wa ... word ''boteille'', from vulgar Latin ''butticula'', from late Latin ''buttis'' ("cask"), a Latinisation (literature), latinisation of the Greek language, Greek βοῦττις (''bouttis'') ("vessel"). Types Glass Wine The glass bottle represented an important development in the history of wine, because, when combined with a high-quality stopper such as a cork, it allowed long-term aging of wine. Glass has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adjuvant
In pharmacology, an adjuvant is a drug or other substance, or a combination of substances, that is used to increase the efficacy or potency of certain drugs. Specifically, the term can refer to: * Adjuvant therapy in cancer management * Analgesic adjuvant in pain management * Immunologic adjuvant In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. The word "adjuvant" comes from the Latin word , meaning to help or aid. "An immunologic adjuvant is defined as any substance that acts to acce ... in vaccines {{sia Adjuvants ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Novavax
Novavax, Inc. is an American biotechnology company based in Gaithersburg, Maryland, that develops vaccines to counter serious infectious diseases. Prior to 2020, company scientists developed experimental vaccines for influenza and respiratory syncytial virus (RSV), as well as Ebola and other emerging infectious diseases. During 2020, the company redirected its efforts to focus on development and approval of its NVX-CoV2373 vaccine for COVID-19. The COVID-19 vaccine Nuvaxovid was approved in the European Union at the end of 2021, and in Canada in February 2022, as the fifth vaccine against COVID-19, following Pfizer/BioNTech, Moderna, Janssen and AstraZeneca. History In June 2013, Novavax acquired the Matrix-M adjuvant platform with the purchase of Swedish company Isconova AB and renamed its new subsidiary Novavax AB. ResVax In March 2015, the company completed a Phase I trial for its Ebola vaccine candidate, as well as a phase II study in adults for its respirator ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccine (journal)
''Vaccine'' is a peer-reviewed medical journal, published by Elsevier. It is targeted towards medical professionals who are interested in vaccinology, vaccines, and vaccination. The official journal of the Edward Jenner Society and the Japanese Society for Vaccinology, ''Vaccine'' describes itself as "an interface between academics, those in research and development, and workers in the field", covering topics "rang ngfrom basic research through to applications, safety and legislation." , Gregory A. Poland is ''Vaccine''s editor-in-chief An editor-in-chief (EIC), also known as lead editor or chief editor, is a publication's editorial leader who has final responsibility for its operations and policies. The editor-in-chief heads all departments of the organization and is held accoun .... References External links Official website Elsevier academic journals English-language journals Academic journals established in 1983 Vaccinology journals Weekly journals {{immunolog ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irritation
Irritation, in biology and physiology, is a state of inflammation or painful reaction to allergy or cell-lining damage. A stimulus or agent which induces the state of irritation is an irritant. Irritants are typically thought of as chemical agents (for example phenol and capsaicin) but mechanical, thermal (heat), and radiative stimuli (for example ultraviolet light or ionising radiations) can also be irritants. Irritation also has non-clinical usages referring to bothersome physical or psychological pain or discomfort. Irritation can also be induced by some allergic response due to exposure of some allergens for example contact dermatitis, irritation of mucosal membranes and pruritus. Mucosal membrane is the most common site of irritation because it contains secretory glands that release mucus which attracts the allergens due to its sticky nature. Chronic irritation is a medical term signifying that afflictive health conditions have been present for a while. There are many dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Foot-and-mouth Disease
Foot-and-mouth disease (FMD) or hoof-and-mouth disease (HMD) is an infectious disease, infectious and sometimes fatal virus (biology), viral disease that primarily affects even-toed ungulates, including domestic and wild Bovidae, bovids. The virus causes a high fever lasting two to six days, followed by vesicle (dermatology), blisters inside the mouth and near the hoof that may rupture and cause lameness. FMD has very severe implications for animal farming, since it is highly infectious and can be spread by infected animals comparatively easily through contact with contaminated farming equipment, vehicles, clothing, and feed, and by domestic and wild predators. Its containment demands considerable efforts in vaccine, vaccination, strict monitoring, trade restrictions, quarantines, and the culling of both infected and healthy (uninfected) animals. Susceptible animals include cattle, domestic water buffalo, water buffalo, domestic sheep, sheep, goats, pigs, antelope, deer, and b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
