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Pseudohermaphroditism
Pseudohermaphroditism is an outdated term for when an individual's gonads were mismatched with their internal reproductive system and/or external genitalia. The term was contrasted with "true hermaphroditism" (now known as ovotesticular syndrome), a condition describing an individual with both female and male reproductive gonadal tissues. Associated conditions includes Persistent Müllerian duct syndrome and forms of androgen insensitivity syndrome. Mechanism Sexual development is determined by chromosomes during fertilization. In the early stages of human development, a human embryo has the Sexual differentiation in humans, precursors of female (paramesonephric or Müllerian ducts) and male (mesonephric ducts or Wolffian) gonads. If a Y chromosome is lacking, or defective as seen in XY gonadal dysgenesis, Swyer syndrome, the embryo will reabsorb the mesonephric ducts and proceed with paramesonephric ducts, which give rise to ovaries. The Y chromosome contains a sex-determining r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intersex
Intersex people are those born with any of several sex characteristics, including chromosome patterns, gonads, or genitals that, according to the Office of the United Nations High Commissioner for Human Rights, "do not fit typical binary notions of male or female bodies". Sex assignment at birth usually aligns with a child's external genitalia. The number of births with ambiguous genitals is in the range of 1:4,500–1:2,000 (0.02%–0.05%). Other conditions involve the development of atypical chromosomes, gonads, or hormones. The portion of the population that is intersex has been reported differently depending on which definition of intersex is used and which conditions are included. Estimates range from 0.018% (one in 5,500 births) to 1.7%. The difference centers on whether conditions in which chromosomal sex matches a phenotypic sex which is clearly identifiable as male or female, such as late onset congenital adrenal hyperplasia (1.5 percentage points) and Kline ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Androgen Insensitivity Syndrome
Androgen insensitivity syndrome (AIS) is a condition involving the inability to respond to androgens, typically due to androgen receptor dysfunction. It affects 1 in 20,000 to 64,000 XY (karyotype, karyotypically male) births. The condition results in the partial or complete inability of Animal cell, cells to respond to androgens. This unresponsiveness can impair or prevent the Development of the reproductive system, development of male genitals, as well as impairing or preventing the development of male Secondary sex characteristics, secondary sexual characteristics at puberty. It does not significantly impair female genital or sexual development. The insensitivity to androgens is therefore clinically significant only when it occurs in genetic males, (i.e. individuals with a Y chromosome, Y-chromosome, or more specifically, an SRY, SRY gene). Clinical phenotypes in these individuals range from a typical body shape, male habitus with mild spermatogenesis, spermatogenic defect or re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disorders Of Sex Development
Disorders of sex development (DSDs), also known as differences in sex development, variations in sex characteristics (VSC), sexual anomalies, or sexual abnormalities, are congenital conditions affecting the reproductive system, in which development of chromosomal, gonadal, or anatomical sex is atypical. DSDs are subdivided into groups in which the labels generally emphasize the karyotype's role in diagnosis: 46,XX; 46,XY; sex chromosome; XX, sex reversal; ovotesticular disorder; and XY, sex reversal. Infants born with atypical genitalia often cause confusion and distress for the family. Psychosexual development is influenced by numerous factors that include, but are not limited to, gender differences in brain structure, genes associated with sexual development, prenatal androgen exposure, interactions with family, and cultural and societal factors. Because of the complex and multifaceted factors involved, communication and psychosexual support are all important. A team of e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Persistent Müllerian Duct Syndrome
Persistent Müllerian duct syndrome (PMDS) is the presence of Müllerian duct derivatives (fallopian tubes, uterus, and/or the upper part of the vagina) in what would be considered a genetically and otherwise physically normal male. In humans, PMDS typically is due to an autosomal recessive congenital disorder and is considered by some to be a form of pseudohermaphroditism due to the presence of Müllerian derivatives. PMDS can also present in non-human animals. Typical features include undescended testes ( cryptorchidism) and the presence of a small, underdeveloped uterus in an XY infant or adult. This condition is usually caused by deficiency of fetal anti-Müllerian hormone (AMH) effect due to mutations of the gene for AMH or the anti-Müllerian hormone receptor, but may also be as a result of insensitivity to AMH of the target organ. Presentation The first visible signs of PMDS after birth is cryptorchidism (undescended testes) either unilaterally or bilaterally, as well ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sexual Differentiation In Humans
Sexual differentiation in humans is the process of development of sex differences in humans. It is defined as the development of phenotypic structures consequent to the action of hormones produced following gonadal determination. Sexual differentiation includes development of different genitalia and the internal genital tracts and body hair plays a role in sex identification. The development of sexual differences begins with the XY sex-determination system that is present in humans, and complex mechanisms are responsible for the development of the phenotypic differences between male and female humans from an undifferentiated zygote. Females typically have two X chromosomes, and males typically have a Y chromosome and an X chromosome. At an early stage in embryonic development, both sexes possess equivalent internal structures. These are the mesonephric ducts and paramesonephric ducts. The presence of the SRY gene on the Y chromosome causes the development of the testes in ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Narave Pig
The Narave or Naravé pig is a type of domestic pig native to northern Vanuatu. Narave pigs are pseudohermaphrodite (intersex) male individuals that are kept for ceremonial purposes. Etymology The term ''narave'' is from Bislama, with the common Oceanic artice ''na-''. Clark (2009) reconstructs Proto- North-Central Vanuatu ''*raβʷe'' ‘hermaphrodite pig, intersex pig’. Reflexes documented in Clark (2009) include Mota ''rawe'' ‘an hermaphrodite pig, female’; Raga ''ravwe'' ‘hermaphrodite (usually of pig)’; Nokuku ''rawe'' ‘boar’ (MacDonald 1889), ''rav'' ‘intersex pig’ (Clark 2005–2007 field notes); Vara Kiai ''rave''; Tamambo ''ravue''; Sakao ''e-re'' ‘intersex pig’; Suñwadaga ''na-raghwe''; Araki ''dave''; Vao ''na-rav'' ‘intersex pigs’, ''bò-rav'' ‘sow’. François (2021) documents Araki ''rave'' �aβe‘hermaphrodite pig, of great customary value’. Endocrinology In the pigs, deficiency of the mitochondrial cytochrome P450 enzym ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Callon Of Epidaurus
Callon (born Callo; fl. 2nd century BC) was an intersex person, whose medical treatment is the first recorded example of gender affirmation surgery. His life is known from the works of Diodorus Siculus. Biography Callon was born in Epidaurus in Greece, during the second half of the second century BC. The details known about Callon's life appear in the ''Bibliotheca Historica'' written by Diodorus Siculus. Assigned female at birth, he is described by Diodorus Siculus as an orphan, who was forced to marry when he "came of age" and lived with his husband for two years. Laura Pfunter interprets Callon's age before marriage as 'pre-pubescent'. Diodorus Siculus reported he had heard that Callon was a priestess prior to his marriage. Although little is known about Callon's married life, Diodorus Siculus recorded that Callon was "not capable of natural Embraces as a Woman" and was forced "to endure those mbracesthat were preternatural, or besides nature". It is recorded that during th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diophantus Of Abae
Diophantus (), born Herais (; 2nd century BC), was an intersex person who lived in the second century BC and fought as a soldier with Alexander Balas. His life is known from the works of Diodorus Siculus. Biography Diophantus was born in the city of Abae, in Arabia, during the reign of Alexander Balas. Assigned female, his birthname was Herais. His father, who was also called Diophantus, was a Macedonian Greek, and he married an Arab woman from the region. The couple's first child, a baby boy also called Diophantus, died at a young age. Diophantus Senior was perhaps a military settler in the region along with many other Macedonians. Diophantus was married to a man named Samias, who travelled abroad after they had been married for one year. Diophantus then fell ill with a fever and a tumour formed at the base of his abdomen.King, Helen (2015). Between male and female in ancient medicine. In: Boschung, Dietrich; Shapiro, Alan and Waschek, Frank eds. Bodies in Transition: Dissolvi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intersex Medical Interventions
Intersex medical interventions (IMI), sometimes known as intersex genital mutilations (IGM), are surgery, surgical, hormonal and other medical interventions performed to modify atypical or ambiguous genitalia and other sex characteristics, primarily for the purposes of making a person's appearance more typical and to reduce the likelihood of future problems. The history of intersex surgery has been characterized by controversy due to reports that surgery can compromise sexual function and sensation, and create lifelong health issues.Submission 88 to the Australian Senate inquiry on the involuntary or coerced sterilisation of people with disabilities in Australia , Australasian P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard University
Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyman John Harvard (clergyman), John Harvard, it is the oldest institution of higher learning in the United States. Its influence, wealth, and rankings have made it one of the most prestigious universities in the world. Harvard was founded and authorized by the Massachusetts General Court, the governing legislature of Colonial history of the United States, colonial-era Massachusetts Bay Colony. While never formally affiliated with any Religious denomination, denomination, Harvard trained Congregationalism in the United States, Congregational clergy until its curriculum and student body were gradually secularized in the 18th century. By the 19th century, Harvard emerged as the most prominent academic and cultural institution among the Boston B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alice Dreger
Alice Domurat Dreger () is an American historian, bioethicist, author, and former professor of clinical medical humanities and bioethics at the Feinberg School of Medicine, Northwestern University, in Chicago, Illinois. Dreger engages in academic work and activism in support of individuals born with atypical sex characteristics (intersex or disorders of sex development) and individuals born as conjoined twins. She challenges the perception that those with physical differences are somehow "broken" and need to be "fixed". She has opposed the use of "corrective" surgery on babies whose genitalia are considered "ambiguous". She has criticized the failure to follow such patients in later life and reported longer-term medical and psychological difficulties experienced by some of the people whose sex is arbitrarily assigned. She supported J. Michael Bailey in the face of controversy over his book '' The Man Who Would Be Queen''. In a 2008 article and in her 2015 book, '' Galileo's M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
