Postprandial Glucose Test
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Postprandial Glucose Test
A postprandial glucose (PPG) test is a blood glucose test that determines the amount of glucose in the plasma after a meal. The diagnosis is typically restricted to ''postprandial hyperglycemia'' due to lack of strong evidence of co-relation with a diagnosis of diabetes''.'' The American Diabetes Association does not recommend a PPG test for determining diabetes, but it notes that postprandial hyperglycemia does contribute to elevated glycated hemoglobin levels (a primary factor behind diabetes) and recommends testing and management of PPG levels for those patients who maintain optimum pre-prandial blood glucose levels but have high A1C values. Carbohydrates in the form of glucose are one of the main constituents of foods, and assimilation starts within about 10 minutes. The subsequent rate of absorption of carbohydrates in conjunction with the resultant rates of secretion of insulin and glucagon secretion affects the time-weighed PPG profile. In non-diabetic individuals, lev ...
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Blood Glucose Test
Many types of glucose tests exist and they can be used to estimate blood sugar levels at a given time or, over a longer period of time, to obtain average levels or to see how fast the body is able to normalize changed glucose levels. Eating food for example leads to elevated blood sugar levels. In healthy people, these levels quickly return to normal via increased cellular glucose uptake which is primarily mediated by increase in blood insulin levels. Glucose tests can reveal temporary/long-term hyperglycemia or hypoglycemia. These conditions may not have obvious symptoms and can damage organs in the long-term. Abnormally high/low levels, slow return to normal levels from either of these conditions and/or inability to normalize blood sugar levels means that the person being tested probably has some kind of medical condition like type 2 diabetes which is caused by cellular insensitivity to insulin. Glucose tests are thus often used to diagnose such conditions. Testing methods Tes ...
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Deciliter
The litre ( Commonwealth spelling) or liter (American spelling) (SI symbols L and l, other symbol used: ℓ) is a metric unit of volume. It is equal to 1 cubic decimetre (dm3), 1000 cubic centimetres (cm3) or 0.001 cubic metres (m3). A cubic decimetre (or litre) occupies a volume of (see figure) and is thus equal to one-thousandth of a cubic metre. The original French metric system used the litre as a base unit. The word ''litre'' is derived from an older French unit, the '' litron'', whose name came from Byzantine Greek—where it was a unit of weight, not volume—via Late Medieval Latin, and which equalled approximately 0.831 litres. The litre was also used in several subsequent versions of the metric system and is accepted for use with the SI, despite it not being an SI unit. The SI unit of volume is the cubic metre (m3). The spelling used by the International Bureau of Weights and Measures is "litre",
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Oxyhyperglycemia
Oxyhyperglycemia is a special type of impaired glucose tolerance characterized by a rapid and transient hyperglycemia (i.e. rise in blood glucose) spike after an oral intake of glucose, the peak of this spike being high enough to cause transient, symptom free glycosuria (i.e. detectable glucose in urine), but this hyperglycemia reverses rapidly and may even go to hypoglycemia in the later phase. This sharp downstroke overshooting towards hypoglycemia distinguishes this pathologic phenomenon from the artificial hyperglycemia inducible by an intravenous bolus dose of a large amount of glucose solution. Early dumping syndrome patients usually have oxyhyperglycemia associated with any meal or OGTT. The Greek root ''oxy'' means "sharp" or "pointy". The OGTT curve in this condition appears sharp and somewhat pointy (at least relative to the other forms of hyperglycemia)- hence this name.Dorlands dictionary defines oxyhyperglycemia as: :"A condition in which there is slight glycosuria a ...
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Postprandial Dip
In medicine and specifically endocrinology, postprandial dip is a term used to refer to mild hypoglycemia occurring after ingestion of a heavy meal. The dip is thought to be caused by a drop in blood glucose resulting from the body's own normal insulin secretion, which in turn is a response to the glucose load represented by the meal. While postprandial dip is usually physiological after a generous meal, a very sharp or sustained drop in blood glucose may be associated with a disorder of glucose metabolism. See also * Postprandial somnolence * Glucose metabolism * Lateral hypothalamus * Insulin resistance * Hypoglycemia * Oxyhyperglycemia * Diabetes mellitus Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained hyperglycemia, high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or th ... References Endocrinology {{Symptom-stub ...
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OGTT
The glucose tolerance test (GTT, not to be confused with GGT test) is a medical test in which glucose is given and blood samples taken afterward to determine how quickly it is cleared from the blood. The test is usually used to test for diabetes, insulin resistance, impaired beta cell function, and sometimes reactive hypoglycemia and acromegaly, or rarer disorders of carbohydrate metabolism. In the most commonly performed version of the test, an ''oral glucose tolerance test'' (OGTT), a standard dose of glucose is ingested by mouth and blood levels are checked two hours later. Many variations of the GTT have been devised over the years for various purposes, with different standard doses of glucose, different routes of administration, different intervals and durations of sampling, and various substances measured in addition to blood glucose. History The glucose tolerance test was first described in 1923 by Jerome W. Conn. The test was based on the previous work in 1913 by A. T. ...
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Obesity Reviews
''Obesity Reviews'' is a monthly peer-reviewed medical journal, established in 2000, which publishes reviews on all obesity-related disciplines. It is the official journal of the World Obesity Federation and published on their behalf by Wiley-Blackwell. The editor-in-chief is David A. York (Utah State University). Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2017 impact factor of 8.483. According to ''Web of Science'', the 2024 Journal Impact Factor has been 8,0, ranking it in the first quartile of the category " Endocrinogloy and metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...". References External links * {{Official website, https://onlinelibrary.wiley.com/journal/1467789x ...
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Macrovascular Disease
Macrovascular disease is a disease of any large (''macro'') blood vessels in the body. It is a disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. This sometimes occurs when a person has had diabetes for an extended period of time. Fat and blood clots build up in the large blood vessels and stick to the vessel walls. Three common macrovascular diseases are coronary disease (in the heart), cerebrovascular disease (in the brain), and peripheral vascular disease (in the limbs) Macrovascular disease (macroangiopathy) refers to atherosclerosis. Atherosclerosis is a form of arteriosclerosis (thickening and hardening of arterial walls), characterized by plaque deposits of lipids, fibrous connective tissue, calcium, and other blood substances. Atherosclerosis, by definition, affects only medium and large arteries (excluding arterioles). Macrovascular disease is associated with the development of corona ...
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International Diabetes Federation
The International Diabetes Federation (IDF) is an umbrella organisation of over 240 national diabetes associations in more than 161 countries and territories. It is headquartered in Brussels, Belgium. Organization IDF is divided into seven regions, to strengthen the work of national diabetes associations and enhance the collaboration between them. IDF's national diabetes associations are divided into the following regions: Africa (AFR), Europe (EUR), Middle East and North Africa (MENA), North America and Caribbean (NAC), South and Central America (SACA), South East Asia (SEA) and Western Pacific (WP). IDF is associated with the Department of Public Information of the United Nations and is in official relations with the World Health Organization The World Health Organization (WHO) is a list of specialized agencies of the United Nations, specialized agency of the United Nations which coordinates responses to international public health issues and emergencies. It is headqua ...
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Glucagon
Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It raises the concentration of glucose and fatty acids in the bloodstream and is considered to be the main catabolic hormone of the body. It is also used as a Glucagon (medication), medication to treat a number of health conditions. Its effect is opposite to that of insulin, which lowers extracellular glucose. It is produced from proglucagon, encoded by the ''GCG'' gene. The pancreas releases glucagon when the amount of glucose in the bloodstream is too low. Glucagon causes the liver to engage in glycogenolysis: converting stored glycogen into glucose, which is released into the bloodstream. High blood-glucose levels, on the other hand, stimulate the release of insulin. Insulin allows glucose to be taken up and used by insulin-dependent tissues. Thus, glucagon and insulin are part of a feedback system that keeps blood glucose levels stable. Glucagon increases energy expenditure and is elevated under conditions ...
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Glucose
Glucose is a sugar with the Chemical formula#Molecular formula, molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, using energy from sunlight. It is used by plants to make cellulose, the most abundant carbohydrate in the world, for use in cell walls, and by all living Organism, organisms to make adenosine triphosphate (ATP), which is used by the cell as energy. In energy metabolism, glucose is the most important source of energy in all organisms. Glucose for metabolism is stored as a polymer, in plants mainly as amylose and amylopectin, and in animals as glycogen. Glucose circulates in the blood of animals as blood sugar. The naturally occurring form is -glucose, while its Stereoisomerism, stereoisomer L-glucose, -glucose is produced synthetically in comparatively small amounts and is less biologicall ...
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Insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats, and protein by promoting the absorption of glucose from the blood into cells of the liver, fat cell, fat, and skeletal muscles. In these tissues the absorbed glucose is converted into either glycogen, via glycogenesis, or Fatty acid metabolism#Glycolytic end products are used in the conversion of carbohydrates into fatty acids, fats (triglycerides), via lipogenesis; in the liver, glucose is converted into both. Glucose production and secretion by the liver are strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is thus an anabolic hormone, promoting the conversion of small molecules in the blood into large ...
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Assimilation (biology)
Assimilation in biology is a crucial metabolic process in which absorbed nutrients are transformed into complex biomolecules that become an integral part of an organism’s cellular structure and function. It occurs after digestion and absorption, ensuring that essential macromolecules—such as carbohydrates, proteins, and lipids—are synthesized and utilized for growth, repair, and maintenance of bodily functions. For instance, monosaccharides like glucose, derived from carbohydrate digestion, enter cells via facilitated diffusion or active transport. Once inside, glucose undergoes glycolysis, the Krebs cycle, and oxidative phosphorylation to generate ATP, which fuels cellular activities. Similarly, amino acids absorbed from dietary proteins are assimilated into cells and serve as precursors for protein synthesis, supporting enzymatic reactions, muscle development, and tissue repair. Fatty acids and glycerol, obtained from lipid digestion, are reassembled into triglycerides and ...
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