|
Polycythemia Vera
In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. Approximately 98% of PV patients have a JAK2 gene mutation in their blood-forming cells (compared with 0.1-0.2% of the general population). Most of the health concerns associated with PV, such as thrombosis, are caused by the blood being Hemorheology, thicker as a result of the increased red blood cells. PV may be symptomatic or asymptomatic. Possible symptoms include itching (pruritus), particularly after exposure to warm water, and severe burning pain in the hands or feet that is usually accompanied by a Erythema, reddish or Cyanosis, bluish coloration of the skin. Treatment consists primarily of blood withdrawals (phlebotomy) and oral meds. PV is more common in the elderly. Signs and symptoms Symptoms People with PV can be asymptomatic. Symptoms of PVhttps://www.lls.org/myeloproliferative-neoplasms/polycythemia-vera/signs-and-symptoms t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncology
Oncology is a branch of medicine that deals with the study, treatment, diagnosis, and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's Etymology, etymological origin is the Greek word ὄγκος (''ónkos''), meaning "tumor", "volume" or "mass". Oncology is focused on the diagnosis of cancer in a person, therapy (e.g., surgery, chemotherapy, radiotherapy and other modalities), monitoring of patients after treatment, palliative care of people with advanced-stage cancers, Ethics, ethical questions surrounding cancer care, Screening (medicine), screening of patients, and the study of cancer treatments through clinical research. An oncologist typically focuses on a specialty area in cancer treatment, such as surgery, Radiation therapy, radiation, gynecology, gynecologic oncology, geriatrics, geriatric oncology, pediatrics, pediatric oncology, and various organ-specific disciplines (breast, brain, liver, among others). The exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
URAC
URAC is a Washington, DC–based non-profit organization that provides accreditation of organizations involved in medical care services, as well as education and measurement programs. Founded under the name Utilization Review Accreditation Commission in 1990, the name was shortened to the acronym URAC in 1996. Offices URAC offices are located in Washington, DC. About half of URAC staff members work from the Washington, DC office and half work from home offices. Accreditation programs URAC's accreditation programs include specialty pharmacy, digital health, utilization management, health plan, case management, and others. In order to earn an accreditation, organizations submit various policies and procedures which are reviewed by a nurse or pharmacist A pharmacist, also known as a chemist in English in the Commonwealth of Nations, Commonwealth English, is a healthcare professional who is knowledgeable about preparation, mechanism of action, clinical usage and legisl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gout
Gout ( ) is a form of inflammatory arthritis characterized by recurrent attacks of pain in a red, tender, hot, and Joint effusion, swollen joint, caused by the deposition of needle-like crystals of uric acid known as monosodium urate crystals. Pain typically comes on rapidly, reaching maximal intensity in less than 12 hours. The Metatarsophalangeal joint, joint at the base of the Hallux, big toe is affected (''Podagra'') in about half of cases. It may also result in Tophus, tophi, kidney stones, or Urate nephropathy, kidney damage. Gout is due to persistently elevated levels of uric acid (urate) in the blood (hyperuricemia). This occurs from a combination of diet, other health problems, and genetic factors. At high levels, uric acid crystallizes and the crystals deposit in joints, tendons, and surrounding tissues, resulting in an attack of gout. Gout occurs more commonly in those who regularly drink beer or sugar-sweetened beverages; eat foods that are high in purines such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myelofibrosis
Primary myelofibrosis (PMF) is a rare bone marrow blood cancer. It is classified by the World Health Organization (WHO) as a type of myeloproliferative neoplasm, a group of cancers in which there is activation and growth of mutated cells in the bone marrow. This is most often associated with a somatic mutation in the '' JAK2'', '' CALR'', or '' MPL'' genes. In PMF, the bony aspects of bone marrow are remodeled in a process called osteosclerosis; in addition, fibroblasts secrete collagen and reticulin proteins that are collectively referred to as fibrosis. These two pathological processes compromise the normal function of bone marrow, resulting in decreased production of blood cells such as erythrocytes (red cells), granulocytes, and megakaryocytes. The latter are responsible for the production of platelets. Signs and symptoms include fever, night sweats, bone pain, fatigue, and abdominal pain. Increased infections, bleeding and an enlarged spleen ( splenomegaly) are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Splenomegaly
Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen. Splenomegaly is one of the four cardinal signs of ''hypersplenism'' which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the potential for correction of these abnormalities by splenectomy. Splenomegaly is usually associated with increased workload (such as in hemolytic anemias), which suggests that it is a response to hyperfunction. It is therefore not surprising that splenomegaly is associated with any disease process that involves abnormal red blood cells being destroyed in the spleen. Other common causes include congestion due to portal hypertension and infiltration by leukemias and lymphomas. Thus, the finding of an enlarged spleen, along with caput medusae, is an important sign of portal hypertension ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polycythemia Vera
In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. Approximately 98% of PV patients have a JAK2 gene mutation in their blood-forming cells (compared with 0.1-0.2% of the general population). Most of the health concerns associated with PV, such as thrombosis, are caused by the blood being Hemorheology, thicker as a result of the increased red blood cells. PV may be symptomatic or asymptomatic. Possible symptoms include itching (pruritus), particularly after exposure to warm water, and severe burning pain in the hands or feet that is usually accompanied by a Erythema, reddish or Cyanosis, bluish coloration of the skin. Treatment consists primarily of blood withdrawals (phlebotomy) and oral meds. PV is more common in the elderly. Signs and symptoms Symptoms People with PV can be asymptomatic. Symptoms of PVhttps://www.lls.org/myeloproliferative-neoplasms/polycythemia-vera/signs-and-symptoms t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatigue
Fatigue is a state of tiredness (which is not sleepiness), exhaustion or loss of energy. It is a signs and symptoms, symptom of any of various diseases; it is not a disease in itself. Fatigue (in the medical sense) is sometimes associated with medical conditions including autoimmune disease, organ failure, chronic pain conditions, mood disorders, heart disease, infectious diseases, and post-infectious-disease states. However, fatigue is complex and in up to a third of primary care cases no medical or psychiatric diagnosis is found. Fatigue (in the general usage sense of normal tiredness) often follows prolonged physical or mental activity. Physical fatigue results from muscle fatigue brought about by intense physical activity. Mental fatigue results from prolonged periods of Cognition, cognitive activity which impairs cognitive ability, can manifest as sleepiness, lethargy, or directed attention fatigue, and can also impair physical performance. Definition Fatigue in a medica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Night Sweats
Night sweats or nocturnal hyperhydrosis is the repeated occurrence of excessive sweating during sleep. The person may or may not also perspire excessively while awake. One of the most common causes of night sweats in women over 40 is the hormonal changes related to menopause and perimenopause. This is a very common occurrence during the menopausal transition years. Over 80% of women experience hot flashes, which may include excessive sweating, during menopause. Night sweats range from being relatively harmless to a sign of underlying disease. Night sweats may happen because the sleep environment is too warm, either because the bedroom is unusually hot or because there are too many covers on the bed. Night sweats have been associated with a long list of clinical conditions. However, there is very little evidence that supports clinical recommendations for this condition. Associated conditions The condition may be a sign of various disease states, including but not exclusive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aspirin
Aspirin () is the genericized trademark for acetylsalicylic acid (ASA), a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and inflammation, and as an antithrombotic. Specific inflammatory conditions that aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. For pain or fever, effects typically begin within 30 minutes. Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. One common adverse effect is an upset stomach. More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on other blood thinners. Aspirin is not recommended in the last part of pregnancy. It is not generally recommended in children with infections ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyanosis
Cyanosis is the change of Tissue (biology), tissue color to a bluish-purple hue, as a result of decrease in the amount of oxygen bound to the hemoglobin in the red blood cells of the capillary bed. Cyanosis is apparent usually in the Tissue (biology), body tissues covered with thin skin, including the mucous membranes, lips, nail beds, and ear lobes. Some medications may cause discoloration such as medications containing amiodarone or silver. Furthermore, mongolian spots, large birthmarks, and the consumption of food products with blue or purple dyes can also result in the bluish skin tissue discoloration and may be mistaken for cyanosis. Appropriate physical examination and history taking is a crucial part to diagnose cyanosis. Management of cyanosis involves treating the main cause, as cyanosis is not a disease, but rather a symptom. Cyanosis is further classified into central cyanosis and peripheral cyanosis. Pathophysiology The mechanism behind cyanosis is different dep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythromelalgia
Erythromelalgia, or Mitchell's disease (after Silas Weir Mitchell (physician), Silas Weir Mitchell), is a rare vascular peripheral pain disorder in which blood vessels, usually in the Human leg, lower extremities or hands, are episodically blocked (frequently on and off daily), then become hyperemic and Inflammation, inflamed. There is severe burning pain (in the small fiber sensory nerves) and Erythema, skin redness. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or Psychological stress, stress. Erythromelalgia may occur either as a primary or secondary disorder (i.e. a disorder in and of itself or a symptom of another condition). Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, polycythemia vera, essential thrombocythemia, hypercholesterolemia, mushroom poisoning, mushroom or mercury poisoning, and some autoimmune disorders. Primary erythromelalgia is caused by mutation of the volta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prostaglandin
Prostaglandins (PG) are a group of physiology, physiologically active lipid compounds called eicosanoids that have diverse hormone-like effects in animals. Prostaglandins have been found in almost every Tissue (biology), tissue in humans and other animals. They are derived enzymatically from the fatty acid arachidonic acid. Every prostaglandin contains 20 carbon atoms, including a carbon ring, 5-carbon ring. They are a subclass of eicosanoids and of the prostanoid class of fatty acid derivatives. The structural differences between prostaglandins account for their different biological activities. A given prostaglandin may have different and even opposite effects in different tissues in some cases. The ability of the same prostaglandin to stimulate a reaction in one tissue and inhibit the same reaction in another tissue is determined by the type of receptor (biochemistry), receptor to which the prostaglandin binds. They act as autocrine or paracrine factors with their target cells ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
