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Phototoxicity
Phototoxicity, also called photoirritation, is a chemically induced skin irritation, requiring light, that does not involve the immune system. It is a type of photosensitivity. The skin response resembles an exaggerated sunburn. The involved chemical may enter into the skin by topical administration, or it may reach the skin via systemic circulation following ingestion or parenteral administration. The chemical needs to be "photoactive," which means that when it absorbs light, the absorbed energy produces molecular changes that cause toxicity. Many synthetic compounds, including drug substances like tetracyclines or fluoroquinolones, are known to cause these effects. Surface contact with some such chemicals causes photodermatitis, and many plants cause phytophotodermatitis. Light-induced toxicity is a common phenomenon in humans; however, it also occurs in other animals. Scientific background A phototoxic substance is a chemical compound which becomes toxic when exposed to ligh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heracleum Mantegazzianum
''Heracleum mantegazzianum'', commonly known as giant hogweed, is a monocarpic perennial herbaceous plant in the carrot family Apiaceae. ''H. mantegazzianum'' is also known as cartwheel-flower, giant cow parsley, giant cow parsnip, or hogsbane. In New Zealand, it is also sometimes called wild parsnip (not to be confused with ''Pastinaca sativa'') or wild rhubarb. Giant hogweed is native to the western Caucasus region of Eurasia. It was introduced to Britain as an ornamental plant in the 19th century, and has also spread to other areas in Western Europe, the United States, and Canada. Its close relatives, Heracleum sosnowskyi, Sosnowsky's hogweed and Persian hogweed, have similarly spread to other parts of Europe. The sap of giant hogweed is Phototoxicity, phototoxic and causes phytophotodermatitis in humans, resulting in blisters and scars. These serious reactions are due to the furanocoumarin derivatives in the leaves, roots, stems, flowers, and seeds of the plant. Consequ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bergamot Essential Oil
Bergamot essential oil is a cold-pressed essential oil produced by cells inside the rind of a bergamot orange fruit. It is a common flavouring and top note in perfumes. The scent of bergamot essential oil is similar to a sweet light orange peel oil with a floral note. Production The '' sfumatura'' or slow-folding process was the traditional technique for manually extracting the bergamot oil. By more modern methods, the oil is extracted mechanically with machines called peelers, which scrape the outside of the fruit under running water to get an emulsion channeled into centrifuges for separating the essence from the water. The rinds of 100 bergamot oranges yield about of bergamot oil. Uses Bergamot essential oil has been used in cosmetics, aromatherapy, and as a flavoring in food and beverages. Its citrus scent makes it a natural flavoring and deodorizing agent. The volatile oils of the bergamot orange are described as flavoring agents in the USP Food Chemicals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photosensitivity
Photosensitivity is the amount to which an object reacts upon receiving photons, especially visible light. In medicine, the term is principally used for abnormal reactions of the skin, and two types are distinguished, photoallergy and phototoxicity. The photosensitive ganglion cells in the mammalian eye are a separate class of light-detecting cells from the photoreceptor cells that function in vision. Skin reactions Human medicine Sensitivity of the skin to a light source can take various forms. People with particular skin types are more sensitive to sunburn. Particular medications make the skin more sensitive to sunlight; these include most of the tetracycline antibiotics, heart drugs amiodarone, and sulfonamides. Some dietary supplements, such as St. John's Wort, include photosensitivity as a possible side effect. Particular conditions lead to increased light sensitivity. Patients with systemic lupus erythematosus experience skin symptoms after sunlight exposure; some typ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heracleum Sosnowskyi
''Heracleum sosnowskyi'', or Sosnowsky's hogweed, is a monocarpic perennial herbaceous flowering plant in the carrot family Apiaceae. Its native range includes the central and eastern Caucasus regions and Transcaucasia. The native ranges of ''Heracleum sosnowskyi'' and '' H. mantegazzianum'', a close relative, overlap in the Caucasus region. Sosnowsky's hogweed is now a common weed in the Baltic States, Belarus, Poland, Russia, and Ukraine. Description ''Heracleum sosnowskyi'' is in height, with a straight, firm stem that can reach a diameter of . The leaves are long. The root is very firm, up to diameter. The inflorescence is a big umbel found at the end of every stem. It blooms from July to September and produces thousands of seeds, which are easily distributed by wind, but especially by water. As Sosnowsky's hogweed is a monocarpic perennial species, the entire plant (including the root) dies after flowering and producing seed. Similar species Similarly tall invasi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photosensitivity In Humans
Light sensitivity or photosensitivity refers to a notable or increased reactivity to light. Apart from vision, human beings have many physiological and psychological responses to light. In rare individuals an atypical response may result in serious discomfort, disease, or injury. Some drugs have a photosensitizing effect. Properties of natural or artificial light that may abnormally affect people include: * Timing of light (upset of normal circadian rhythms, seasonal affective disorder, sleep disorders) * Intensity of light (photophobia, sunburn, skin cancer) * Wavelength of light (in lupus, urticaria) * Rapid flickers in intensity of light may trigger or aggravate photosensitive epilepsy, epileptic seizure, or migraine headaches. 2 Photoaggravated Disordersat European Dermatology Forum * Atopic eczema *Mastocytosis * Mast cell activation syndrome * Histamine intolerance * Erythema multiforme *Seborrhoeic dermatitis *Autoimmune bullous diseases ( immunobullous diseases) * Mycosi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Common Rue
''Ruta graveolens'', commonly known as rue, common rue or herb-of-grace, is a species of the genus ''Ruta'' grown as an ornamental plant and herb. It is native to the Mediterranean. It is grown throughout the world in gardens, especially for its bluish leaves, and sometimes for its tolerance of hot and dry soil conditions. It is also cultivated as a culinary herb, and to a lesser extent as an insect repellent and incense. Etymology The specific epithet ''graveolens'' refers to the strong-smelling leaves.J. D. Douglas and Merrill C. Tenney Description Rue is a woody, perennial shrub. Its leaves are oblong, blue green and arranged bipinnately with rounded leaflets; they release a strong aroma when they are bruised. The flowers are small with 4 to 5 dull yellow petals in cymes. The first flower in each cyme is pentamerous (five sepals, five petals, five stamens and five carpels. All the others are tetramerous (four of each part). They bear brown seed capsules when pollinate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quinolone Antibiotic
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production. Quinolone antibiotics are classified into four generations based on their spectrum of activity and chemical modifications. The first-generation quinolones, such as nalidixic acid, primarily target Gram-negative bacteria and are mainly used for urinary tract infections. Second-generation quinolones introduced fluorine atoms into their structure, creating fluoroquinolones, which significantly expanded their antibacterial activity to include some Gram-positive bacteria. Third-generation fluoroquinolones further improved Gram-positive coverage, while fourth-generation fluoroquinolones offer broad-spectrum activity, including anaerobic bacteria. Only quinolone antibiotics in generat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heme
Heme (American English), or haem (Commonwealth English, both pronounced /Help:IPA/English, hi:m/ ), is a ring-shaped iron-containing molecule that commonly serves as a Ligand (biochemistry), ligand of various proteins, more notably as a Prosthetic group, component of hemoglobin, which is necessary to bind oxygen in the bloodstream. It is composed of four pyrrole rings with 2 Vinyl group, vinyl and 2 propionic acid side chains. Heme is biosynthesized in both the bone marrow and the liver. Heme plays a critical role in multiple different redox reactions in mammals, due to its ability to carry the oxygen molecule. Reactions include oxidative metabolism (cytochrome c oxidase, succinate dehydrogenase), xenobiotic detoxification via cytochrome P450 pathways (including Drug metabolism, metabolism of some drugs), gas sensing (Guanylate cyclase, guanyl cyclases, nitric oxide synthase), and microRNA processing (DGCR8). Heme is a coordination complex "consisting of an iron ion coordinated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Disorder
A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosome abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a single genetic cause, either in a gene or chromosome. The mutation responsible can occur spontaneously before embryonic development (a ''de novo'' mutation), or it can be inherited from two parents who are carriers of a faulty gene ( autosomal recessive inheritance) or from a parent with the disorder (autosomal dominant inheritance). When the genetic disorder is inherited from one or both parents, it is also classified as a hereditary disease. Some disorders are caused by a mutation on the X chromosome and have X-linked inheritance. Very few disorders are inherited on the Y chromosome or mitochondrial DNA (due to their size). There are well over 6,000 known ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Porphyrin
Porphyrins ( ) are heterocyclic, macrocyclic, organic compounds, composed of four modified pyrrole subunits interconnected at their α carbon atoms via methine bridges (). In vertebrates, an essential member of the porphyrin group is heme, which is a component of hemoproteins, whose functions include carrying oxygen in the bloodstream. In plants, an essential porphyrin derivative is chlorophyll, which is involved in light harvesting and electron transfer in photosynthesis. The parent of porphyrins is porphine, a rare chemical compound of exclusively theoretical interest. Substituted porphines are called porphyrins. With a total of 26 π-electrons the porphyrin ring structure is a coordinated aromatic system. One result of the large conjugated system is that porphyrins absorb strongly in the visible region of the electromagnetic spectrum, i.e. they are deeply colored. The name "porphyrin" derives . Structure Porphyrin complexes consist of a square planar MN4 core. The p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heracleum Persicum
''Heracleum persicum'', commonly known as Persian hogweed or by its native name ''golpar'' (), is a species of hogweed, a perennial herbaceous plant in the carrot family Apiaceae. It grows wild in humid mountainous regions in Iran and some adjacent areas. Having been introduced in the 1830s, it has spread across Scandinavia. It is now very common in northern Norway, where one of its names is Tromsø palm (after the city of Tromsø). The plant has also been spotted in Sweden. In Finland, it has been declared an invasive species. Persian hogweed is a polycarpic perennial, that is, a mature plant flowers and bears fruit season after season. Invasiveness status In Europe, Persian hogweed is included since 2016 in the list of Invasive Alien Species of Union concern (the Union list). This implies that this species cannot be imported, cultivated, transported, commercialized, planted, or intentionally released into the environment in the whole of the European Union. Uses Food uses ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lime (fruit)
A lime is a citrus fruit, which is typically round, lime (color), lime green in colour, in diameter, and contains acidic juice vesicles. There are several species of citrus trees whose fruits are called limes, including the Key lime (''Citrus aurantiifolia''), Persian lime, kaffir lime, finger lime, blood lime, and Citrus glauca, desert lime. Limes are a rich source of vitamin C, are sour, and are often used to accent the flavours of foods and beverages. They are grown year-round. Plants with fruit called "limes" have diverse genetic origins; limes do not form a monophyletic group. The term ''lime'' originated in other languages (from French language, French , from Arabic , from Persian language, Persian , ). Plants known as "lime" The difficulty in identifying exactly which species of fruit are called lime in different parts of the English-speaking world (the same problem applies to synonyms in other European languages) is increased by the botanical complexity of the ''Citru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
