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Phase Precession
Phase precession is a neurophysiological process in which the time of firing of action potentials by individual neurons occurs progressively earlier in relation to the phase of the local field potential oscillation with each successive cycle. In place cells, a type of neuron found in the hippocampal region of the brain, phase precession is believed to play a major role in the neural coding of information. John O'Keefe, who later shared the 2014 Nobel Prize in Physiology or Medicine for his discovery that place cells help form a "map" of the body's position in space, co-discovered phase precession with Michael Recce in 1993. Place cells Pyramidal cells in the hippocampus called place cells play a significant role in self-location during movement over short distances. As a rat moves along a path, individual place cells fire action potentials at an increased rate at particular positions along the path, termed "place fields". Each place cell's maximum firing ratewith action pot ...
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Hippocampus Proper
The hippocampal subfields are four subfields CA1, CA2, CA3, and CA4 that make up the structure of the hippocampus. Regions described in the hippocampus are the head, body, and tail, and other hippocampal subfields include the dentate gyrus, the presubiculum, and the subiculum. The CA subfields use the initials of Hippocampus#Name, cornu ammonis, an earlier name of the hippocampus. Structure There are four hippocampal subfields, in the hippocampus proper which form a neural circuit called the trisynaptic circuit. CA1 CA1 is the first region in the hippocampal circuit, from which a significant output pathway goes to layer V of the entorhinal cortex. The main output of CA1 is to the subiculum. CA2 CA2 is a small region located between CA1 and CA3. It receives some input from layer II of the entorhinal cortex via the perforant path. Its pyramidal cells are more like those in CA3 than those in CA1. It is often ignored due to its small size. CA3 CA3 receives input from the mossy fi ...
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Michael Recce
Michael may refer to: People * Michael (given name), a given name * he He ..., a given name * Michael (surname), including a list of people with the surname Michael Given name * Michael (bishop elect)">Michael (surname)">he He ..., a given name * Michael (surname), including a list of people with the surname Michael Given name * Michael (bishop elect), English 13th-century Bishop of Hereford elect * Michael (Khoroshy) (1885–1977), cleric of the Ukrainian Orthodox Church of Canada * Michael Donnellan (fashion designer), Michael Donnellan (1915–1985), Irish-born London fashion designer, often referred to simply as "Michael" * Michael (footballer, born 1982), Brazilian footballer * Michael (footballer, born 1983), Brazilian footballer * Michael (footballer, born 1993), Brazilian footballer * Michael (footballer, born February 1996), Brazilian footballer * Michael (footballer, born March 1996), Brazilian footballer * Michael (footballer, born 1999), Brazilian footballer ...
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Grid Cell
A grid cell is a type of neuron within the entorhinal cortex that fires at regular intervals as an animal navigates an open area, allowing it to understand its position in space by storing and integrating information about location, distance, and direction. Grid cells have been found in many animals, including Laboratory rat, rats, laboratory mouse, mice, bats, Monkey#In experiments, monkeys, and humans. Grid cells were discovered in 2005 by Edvard Moser, May-Britt Moser, and their students Torkel Hafting, Marianne Fyhn, and Sturla Molden at the Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Centre for the Biology of Memory (CBM) in Norway. They were awarded the 2014 Nobel Prize in Physiology or Medicine together with John O'Keefe (neuroscientist), John O'Keefe for their discoveries of cells that constitute a positioning system in the brain. The arrangement of spatial firing fields, all at equal distances from their neighbors, led to a hypothesis t ...
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Theta Wave
Theta waves generate the theta rhythm, a neural oscillation in the brain that underlies various aspects of cognition and behavior, including learning, memory, and spatial navigation in many animals. It can be recorded using various electrophysiological methods, such as electroencephalogram (EEG), recorded either from inside the brain or from electrodes attached to the scalp. At least two types of theta rhythm have been described. The hippocampal theta rhythm is a strong oscillation that can be observed in the hippocampus and other brain structures in numerous species of mammals including rodents, rabbits, dogs, cats, and marsupials. ''"Cortical theta rhythms"'' are low-frequency components of scalp EEG, usually recorded from humans. Theta rhythms can be quantified using quantitative electroencephalography (qEEG) using freely available toolboxes, such as, EEGLAB or the Neurophysiological Biomarker Toolbox (NBT). In rats, theta wave rhythmicity is easily observed in the hipp ...
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Phase Precession
Phase precession is a neurophysiological process in which the time of firing of action potentials by individual neurons occurs progressively earlier in relation to the phase of the local field potential oscillation with each successive cycle. In place cells, a type of neuron found in the hippocampal region of the brain, phase precession is believed to play a major role in the neural coding of information. John O'Keefe, who later shared the 2014 Nobel Prize in Physiology or Medicine for his discovery that place cells help form a "map" of the body's position in space, co-discovered phase precession with Michael Recce in 1993. Place cells Pyramidal cells in the hippocampus called place cells play a significant role in self-location during movement over short distances. As a rat moves along a path, individual place cells fire action potentials at an increased rate at particular positions along the path, termed "place fields". Each place cell's maximum firing ratewith action pot ...
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Phase Resetting In Neurons
Phase resetting in neurons is a behavior observed in different oscillators, biological oscillators and plays a role in creating neural synchronization as well as different processes within the body. Phase resetting in neurons is when the dynamical behavior of an oscillation is shifted. This occurs when a stimulus perturbs the phase within an oscillatory cycle and a change in period occurs. The periods of these oscillations can vary depending on the biological system, with examples such as: (1) neural responses can change within a millisecond to quickly relay information; (2) In cardiac and respiratory changes that occur throughout the day, could be within seconds; (3) circadian rhythms may vary throughout a series of days; (4) rhythms such as hibernation may have periods that are measured in years.Krogh-Madsen, Trine, et al. "Phase Resetting Neural Oscillators: Topological Theory Versus the RealWorld." Phase response curves in neuroscience. Springer New York, 2012. 33-51. This acti ...
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Electroencephalography
Electroencephalography (EEG) is a method to record an electrogram of the spontaneous electrical activity of the brain. The biosignal, bio signals detected by EEG have been shown to represent the postsynaptic potentials of pyramidal neurons in the neocortex and allocortex. It is typically non-invasive, with the EEG electrodes placed along the scalp (commonly called "scalp EEG") using the 10–20 system (EEG), International 10–20 system, or variations of it. Electrocorticography, involving surgical placement of electrodes, is sometimes called Electrocorticography, "intracranial EEG". Clinical interpretation of EEG recordings is most often performed by visual inspection of the tracing or quantitative EEG, quantitative EEG analysis. Voltage fluctuations measured by the EEG bioamplifier, bio amplifier and electrodes allow the evaluation of normal Brain activity and meditation, brain activity. As the electrical activity monitored by EEG originates in neurons in the underlying Huma ...
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Voltage
Voltage, also known as (electrical) potential difference, electric pressure, or electric tension, is the difference in electric potential between two points. In a Electrostatics, static electric field, it corresponds to the Work (electrical), work needed per unit of Electric charge, charge to move a positive Test particle#Electrostatics, test charge from the first point to the second point. In the SI unit, International System of Units (SI), the SI derived unit, derived unit for voltage is the ''volt'' (''V''). The voltage between points can be caused by the build-up of electric charge (e.g., a capacitor), and from an electromotive force (e.g., electromagnetic induction in a Electric generator, generator). On a macroscopic scale, a potential difference can be caused by electrochemical processes (e.g., cells and batteries), the pressure-induced piezoelectric effect, and the thermoelectric effect. Since it is the difference in electric potential, it is a physical Scalar (physics ...
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Waveform
In electronics, acoustics, and related fields, the waveform of a signal is the shape of its Graph of a function, graph as a function of time, independent of its time and Magnitude (mathematics), magnitude Scale (ratio), scales and of any displacement in time.David Crecraft, David Gorham, ''Electronics'', 2nd ed., , CRC Press, 2002, p. 62 ''Periodic waveforms'' repeat regularly at a constant wave period, period. The term can also be used for non-periodic or aperiodic signals, like chirps and pulse (signal processing), pulses. In electronics, the term is usually applied to time-varying voltages, electric current, currents, or electromagnetic fields. In acoustics, it is usually applied to steady periodic sounds — variations of air pressure, pressure in air or other media. In these cases, the waveform is an attribute that is independent of the frequency, amplitude, or phase shift of the signal. The waveform of an electrical signal can be visualized with an oscilloscope or an ...
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Neural Ensemble
A neuronal ensemble is a population of nervous system cells (or cultured neurons) involved in a particular neural computation. Background The concept of neuronal ensemble dates back to the work of Charles Sherrington who described the functioning of the CNS as the system of reflex arcs, each composed of interconnected excitatory and inhibitory neurons. In Sherrington's scheme, α-motoneurons are the final common path of a number of neural circuits of different complexity: motoneurons integrate a large number of inputs and send their final output to muscles. Donald Hebb theoretically developed the concept of neuronal ensemble in his famous book "The Organization of Behavior" (1949). He defined "cell assembly" as "a diffuse structure comprising cells in the cortex and diencephalon, capable of acting briefly as a closed system, delivering facilitation to other such systems". Hebb suggested that, depending on functional requirements, individual brain cells could participate i ...
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Phase Response Curve
A phase response curve (PRC) illustrates the transient change (phase response) in the cycle period of an oscillation induced by a perturbation as a function of the phase at which it is received. PRCs are used in various fields; examples of biological oscillations are the heartbeat, circadian rhythms, and the regular, repetitive firing observed in some neurons in the absence of noise. In circadian rhythms In humans and animals, there is a regulatory system that governs the phase relationship of an organism's internal circadian clock to a regular periodicity in the external environment (usually governed by the solar day). In most organisms, a stable phase relationship is desired, though in some cases the desired phase will vary by season, especially among mammals with seasonal mating habits. In circadian rhythm research, a PRC illustrates the relationship between a chronobiotic's time of administration (relative to the internal circadian clock) and the magnitude of the treatment' ...
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