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Northern Rock
Northern Rock, formerly the Northern Rock Building Society, was a British bank. Based at Regent Centre in Newcastle upon Tyne, United Kingdom, Northern Rock was originally a building society. It demutualised and became Northern Rock bank in 1997, when it floated on the London Stock Exchange with the ticker symbol NRK. During the early 2000s the company borrowed substantially to fund mortgages, with the aim of ambitious growth, and also donated large amounts to charitable purposes and communities directly and through sponsorships. Due to the 2008 financial crisis, it was unable to produce income as expected from its loans, and was at risk of being unable to repay the amounts it had borrowed. The news that the bank had approached the government for support with its liquidity led within 24 hours to a public lack of confidence and concerns that savings were at risk, and the bank failed following a bank run as people rushed to withdraw their savings. It was the first British ba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northern Railway (India)
The Northern Railway (NR) is one of the 17 Railway zones of India and the northernmost zone of the Indian Railways. It is headquartered at Baroda House in New Delhi. History Officially notified as a new railway zone on 14 April 1952, its origin goes back to 3 March 1859. On 14 April 1952, the Northern Railway zone was created by merging Jodhpur Railway, Bikaner Railway, Eastern Punjab Railway and three divisions of the East Indian Railway north-west of Mughalsarai (Uttar Pradesh). On 3 March 1859, Allahabad–Kanpur, the first passenger railway line in North India was opened, which falls under Northern Railway zone. In 1864, a broad-gauge track from Calcutta to Delhi was laid. In 1864, the railway line between Old Delhi and Meerut City railway station was constructed. Meerut Cantt railway station was established by British India government around 1865 after the sepoy mutiny of 1857. In 1866, through trains started running on the East Indian Railway Company's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northern Rail
Northern Rail, branded as Northern, was an English train operating company owned by Serco-Abellio that operated the Northern Rail franchise from 2004 until 2016. It was the primary passenger train operator in Northern England, and operated the most stations of any train operating company in the United Kingdom. Northern Rail was replaced on 1 April 2016 by Arriva Rail North. History In 2000 the Strategic Rail Authority announced that it planned to reorganise the Regional Railways North West and Regional Railways North East franchises operated by First North Western and Arriva Trains Northern. A TransPennine Express franchise would be created for the long-distance regional services, with the remaining services to be operated by a new Northern Rail franchise. On 1 July 2004 the Strategic Rail Authority awarded the franchise to Serco-Abellio, Serco-NedRailways, beating FirstGroup. The franchise was awarded for six years and nine months, with a two-year extension subject to perform ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nauru
Nauru, officially the Republic of Nauru, formerly known as Pleasant Island, is an island country and microstate in the South Pacific Ocean. It lies within the Micronesia subregion of Oceania, with its nearest neighbour being Banaba (part of Kiribati) about to the east. With an area of only , Nauru is the List of countries and dependencies by area, third-smallest country in the world, larger than only Vatican City and Monaco, making it the smallest republic and island nation, as well as the smallest member state of the Commonwealth of Nations by area. Demographics of Nauru, Its population of about 10,800 is the world's List of countries and dependencies by population, third-smallest (not including colonies or overseas territories). Nauru is a member of the United Nations, the Commonwealth of Nations, and the Organisation of African, Caribbean and Pacific States. Settled by Micronesians circa 1000 Common Era, BCE, Nauru was annexation, annexed and claimed as a colony by the G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Numerical Recipes
''Numerical Recipes'' is the generic title of a series of books on algorithm In mathematics and computer science, an algorithm () is a finite sequence of Rigour#Mathematics, mathematically rigorous instructions, typically used to solve a class of specific Computational problem, problems or to perform a computation. Algo ...s and numerical analysis by William H. Press, Saul A. Teukolsky, William T. Vetterling and Brian P. Flannery. In various editions, the books have been in print since 1986. The most recent edition was published in 2007. Overview The ''Numerical Recipes'' books cover a range of topics that include both classical numerical analysis (interpolation, Numerical integration, integration, linear algebra, differential equations, and so on), signal processing (Fast Fourier transform, Fourier methods, Digital filter, filtering), statistical treatment of data, and a few topics in machine learning (hidden Markov model, support vector machines). The writing style is acc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These intracellular receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand—a molecule that affects the receptor's behavior. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Nuclear receptors play key roles in both embryonic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northern Rhodesia
Northern Rhodesia was a British protectorate in Southern Africa, now the independent country of Zambia. It was formed in 1911 by Amalgamation (politics), amalgamating the two earlier protectorates of Barotziland-North-Western Rhodesia and North-Eastern Rhodesia.''Commonwealth and Colonial Law'' by Kenneth Roberts-Wray, London, Stevens, 1966. p. 753 It was initially administered, as were the two earlier protectorates, by the British South Africa Company (BSAC), a chartered company, on behalf of the British Government. From 1924, it was administered by the British Government as a protectorate, under similar conditions to other British-administered protectorates, and the special provisions required when it was administered by BSAC were terminated.Northern Rhodesia Order in Council 1924 (SR&O 1924/324), S.R.O. & S.I. Rev VIII, 154 Although under the BSAC charter it had features of a charter colony, the BSAC's treaties with local rulers, and British legislation, gave it the status of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Review
''National Review'' is an American conservative editorial magazine, focusing on news and commentary pieces on political, social, and cultural affairs. The magazine was founded by William F. Buckley Jr. in 1955. Its editor-in-chief is Rich Lowry, and its editor is Ramesh Ponnuru. Since its founding, the magazine has played a significant role in the development of conservatism in the United States, helping to define its boundaries and promoting fusionism while establishing itself as a leading voice on the American right. History Background Before ''National Review''s founding in 1955, the American right was a largely unorganized collection of people who shared intertwining philosophies but had little opportunity for a united public voice. They wanted to marginalize the antiwar, noninterventionistic views of the Old Right. In 1953, moderate Republican Dwight D. Eisenhower was president, and many major magazines such as the '' Saturday Evening Post'', ''Time'', an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Network Rail
Network Rail Limited is the owner (via its subsidiary Network Rail Infrastructure Limited, which was known as Railtrack plc before 2002) and railway infrastructure manager, infrastructure manager of most of the railway network in Great Britain. Network Rail is a non-departmental public body of the Department for Transport with no shareholders, which reinvests its income in the railways. Network Rail's main customers are the private train operating company, train operating companies (TOCs), responsible for passenger transport, and freight operating company, freight operating companies (FOCs), who provide train services on the infrastructure that the company owns and maintains. Since 1 September 2014, Network Rail has been classified as a "public sector body". To cope with history of rail transport in Great Britain 1995 to date, rapidly increasing passenger numbers, () Network Rail has been undertaking a £38 billion History of rail transport in Great Britain 1995 to date#Timelin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicotinamide Riboside
Nicotinamide riboside (NR, SR647) is a pyridine-nucleoside and a form of vitamin B3. It functions as a precursor to nicotinamide adenine dinucleotide, or NAD+, through a two-step and a three-step pathway. Chemistry While the molecular weight of nicotinamide riboside is 255.25 g/mol, that of its chloride salt is 290.70 g/mol. As such, 100 mg of nicotinamide riboside chloride provides 88 mg of nicotinamide riboside. Stability and degradation NRCl is susceptible to degradation through both thermal decomposition and base-catalyzed hydrolysis: * Thermal degradation: Decomposition occurs rapidly at temperatures above 130°C, producing nicotinamide (NAM) and ribose. * Degradation kinetics: NRCl degradation follows pseudo-first-order kinetics, with the degradation rate doubling for every 10°C increase in temperature. At pH 7.4, degradation is significantly faster than in acidic conditions, highlighting the importance of pH control for formulation stability. These propert ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sequence Clustering
In bioinformatics, sequence clustering algorithms attempt to group biological sequences that are somehow related. The sequences can be either of genomic, " transcriptomic" ( ESTs) or protein origin. For proteins, homologous sequences are typically grouped into families. For EST data, clustering is important to group sequences originating from the same gene before the ESTs are assembled to reconstruct the original mRNA. Some clustering algorithms use single-linkage clustering, constructing a transitive closure of sequences with a similarity over a particular threshold. UCLUST and CD-HIT use a greedy algorithm that identifies a representative sequence for each cluster and assigns a new sequence to that cluster if it is sufficiently similar to the representative; if a sequence is not matched then it becomes the representative sequence for a new cluster. The similarity score is often based on sequence alignment. Sequence clustering is often used to make a non-redundant set of rep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norwegian Computing Center
Norwegian Computing Center (NR, in Norwegian: ''Norsk Regnesentral'') is a private, independent, non-profit research foundation. NR carries out contract research and development in the areas of computing and quantitative methods for a broad range of industrial, commercial and public service organizations in Norway and internationally. NR is one of Europe's largest research environments in applied statistics and its projects cover a large variety of applied and academic problems. NR's offices are located near the university campus Blindern in Oslo, and adjacent to Oslo Science Park (Forskningsparken). History NR was established in 1952. Until 1970 an important part of the activity was to perform mathematical computations for other organizations. NR has worked with data communication since 1963. The Simula programming language was designed and built by Ole-Johan Dahl and Kristen Nygaard and their research group at the Norwegian Computing Center in Oslo between 1962 and 1967. Afte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
