|
Non-Langerhans Cell Histiocytosis
Non-Langerhans cell histiocytosis, also known as rare histiocytoses, comprise all histiocyte, macrophage, and dendritic cell proliferative disorders that are not categorized as hemophagocytic lymphohistiocytosis (HLH) or Langerhans cell histiocytosis (LCH). The spectrum of non-langerhans cell histiocytoses include: * Benign cephalic histiocytosis * Generalized eruptive histiocytoma * Indeterminate cell histiocytosis * Juvenile xanthogranuloma * Progressive nodular histiocytoma * Necrobiotic xanthogranuloma * (Giant Cell) Reticulohistiocytoma * Multicentric reticulohistiocytosis * Rosai–Dorfman disease * Xanthoma disseminatum * Kikuchi disease * Erdheim–Chester disease Erdheim–Chester disease (ECD) is an extremely rare disease classified as a non- Langerhans-cell histiocytic neoplasm. In 2016, the World Health Organization (WHO) defined ECD as a slow-growing blood cancer that may originate in the bone marrow o .... References Further reading * * External links ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hematology
Hematology (American and British English spelling differences#ae and oe, spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the production of blood and its components, such as blood cells, hemoglobin, blood proteins, bone marrow, platelets, blood vessels, spleen, and the mechanism of coagulation. Such diseases might include hemophilia, sickle cell anemia, blood clots (thrombus), other bleeding disorders, and blood cancers such as leukemia, multiple myeloma, and lymphoma. The laboratory analysis of blood is frequently performed by a medical technologist or medical laboratory scientist. Specialization Physicians specialized in hematology are known as hematologists or haematologists. Their routine work mainly includes the care and treatment of patients with hematological diseases, although some may also work at the hema ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benign Cephalic Histiocytosis
Malignancy () is the tendency of a medical condition to become progressively worse; the term is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous ''benign'' tumor in that a malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues. A benign tumor has none of those properties, but may still be harmful to health. The term benign in more general medical use characterizes a condition or growth that is not cancerous, i.e. does not spread to other parts of the body or invade nearby tissue. Sometimes the term is used to suggest that a condition is not dangerous or serious. Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by genome instability, so that cancers, as assessed by whole genome sequencing, frequently have between 10,000 and 100,000 mutations in their entire genomes. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Generalized Eruptive Histiocytoma
A generalization is a form of abstraction whereby common properties of specific instances are formulated as general concepts or claims. Generalizations posit the existence of a domain or set of elements, as well as one or more common characteristics shared by those elements (thus creating a conceptual model). As such, they are the essential basis of all valid deductive inferences (particularly in logic, mathematics and science), where the process of verification is necessary to determine whether a generalization holds true for any given situation. Generalization can also be used to refer to the process of identifying the parts of a whole, as belonging to the whole. The parts, which might be unrelated when left on their own, may be brought together as a group, hence belonging to the whole by establishing a common relation between them. However, the parts cannot be generalized into a whole—until a common relation is established among ''all'' parts. This does not mean that the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indeterminate Cell Histiocytosis
Indeterminate cell histiocytosis (LCH) is an uncommon proliferative illness where the predominant cells have characteristics from both non-Langerhans cell histiocytosis (NLCH) and Langerhans cell histiocytosis (LCH) in terms of morphology and immunophenotypic characteristics. Wood et al. originally described ICH in 1985 as a neoplastic disease arising from dermal indeterminate cells that lack Birbeck granules but are characteristically positive for S-100 and CD1a. Signs and symptoms Clinically, ICH is defined by pink to reddish, varying-sized, painless, non-itching papules or nodules that develop on otherwise healthy skin (sparing mucosae). These lesions can appear as a single, distinct group of lesions, or several generalized papules dispersed over the trunk, face, and limbs. They can also show signs of stable disease, remission and recurrence, or spontaneous remission. Causes Possible causes include scabies, mosquito bites, and a clonal drive. Treatment Treatment include 5% ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Juvenile Xanthogranuloma
Juvenile xanthogranuloma is a form of histiocytosis, classified as non-Langerhans cell histiocytosis. It is a rare Skin condition, skin disorder that primarily affects children under one year of age but can also be found in older children and adults. It was first described in 1905 by Adamson. In 5% to 17% of people, the disorder is present at birth, but the median age of onset is two years. JXG is a Benign tumor, benign Idiopathic disease, idiopathic cutaneous granuloma, granulomatous tumor and the most common form of non-Langerhans cell histiocytosis (non-LHC). The lesions appear as orange-red Skin_condition#Primary_lesions, macules or papule, papules and are usually located on the face, neck, and upper trunk. They may also appear at the groin, scrotum, penis, clitoris, toenail, palms, soles, lips, lungs, bone, heart, and gastrointestinal tract more rarely. JXG usually manifests with multiple Lesion, lesions on the head and neck in cases with children under six months of age. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progressive Nodular Histiocytoma
Progressive may refer to: Politics * Progressivism, a political philosophy in support of social reform ** Progressivism in the United States, the political philosophy in the American context ** Progressivism in South Korea, the political philosophy in the South Korean context * Progressive realism, an American foreign policy paradigm focused on producing measurable results in pursuit of widely supported goals Political organizations * Congressional Progressive Caucus, members within the Democratic Party in the United States Congress dedicated to the advancement of progressive issues and positions * Progressive Alliance (other) * Progressive Conservative (other) * Progressive Party (other) * Progressive Unionist (other) Other uses in politics * Progressive Era, a period of reform in the United States (c. 1890–1930) * Progressive tax, a type of tax rate structure Arts, entertainment, and media Music * Progressive music, a type of mu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Necrobiotic Xanthogranuloma
Necrobiotic xanthogranuloma, also known as necrobiotic xanthogranuloma with paraproteinemia, is a multisystem disease that affects older adults, and is characterized by prominent skin findings. See also * List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the Human body, body and composed of Human skin, skin, hair, Nail (anatomy), nails, and related muscle and glands. The major function o ... References External links Monocyte- and macrophage-related cutaneous conditions {{Cutaneous-condition-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multicentric Reticulohistiocytosis
Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50 years, and is twice as common in women. See also * Reticulohistiocytosis * List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the Human body, body and composed of Human skin, skin, hair, Nail (anatomy), nails, and related muscle and glands. The major function o ... References External links Monocyte- and macrophage-related cutaneous conditions {{Cutaneous-condition-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rosai–Dorfman Disease
Rosai–Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy or sometimes as Destombes–Rosai–Dorfman disease, is a rare disorder of unknown cause that is characterized by abundant histiocytes in lymph nodes or other locations including the skin, sinuses, brain and heart. Individuals with the disorder often present with enlarged lymph nodes and a nodular red skin rash. The main causes of morbidity with the illness are systemic infection from impaired immune response and organ dysfunction from histiocyte deposition throughout the body. Signs and symptoms The histiocytosis of Destombes–Rosai–Dorfman disease can occur in lymph nodes, causing lymphadenopathy, or can occur outside lymph nodes in extranodal disease. Lymphadenopathy Lymphadenopathy can occur in one or more groups of lymph nodes. Among 358 cases of Destombes–Rosai–Dorfman disease that Rosai collected in a disease registry for which the location of lymphadenopathy was specified, 87.3% ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Xanthoma Disseminatum
Xanthoma disseminatum is a rare cutaneous condition that preferentially affects males in childhood, characterized by the insidious onset of small, yellow-red to brown papules and nodules that are discrete and disseminated. It is a histiocytosis syndrome. See also * Non-X histiocytosis * List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the Human body, body and composed of Human skin, skin, hair, Nail (anatomy), nails, and related muscle and glands. The major function o ... References External links Monocyte- and macrophage-related cutaneous conditions {{Cutaneous-condition-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kikuchi Disease
Kikuchi disease was described in 1972 in Japan. It is also known as histiocytic necrotizing lymphadenitis, Kikuchi necrotizing lymphadenitis, phagocytic necrotizing lymphadenitis, subacute necrotizing lymphadenitis, and necrotizing lymphadenitis. Kikuchi disease occurs sporadically in people with no family history of the condition. It was first described by Dr Masahiro Kikuchi (1935–2012) in 1972 and independently by Y. Fujimoto. Signs and symptoms The signs and symptoms of Kikuchi disease are fever, enlargement of the lymph nodes (lymphadenopathy), skin rashes, and headache. In sixty to ninety percent of cases, lymphadenopathy presents in the posterior cervical lymph nodes with diameter enlargement typically being between one and two centimeters, but up to seven centimeters has been reported in literature. Occasionally, the supraclavicular and axillary lymph nodes become swollen as well. Rarely, enlargement of the liver and spleen and nervous system involvement resembling meni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erdheim–Chester Disease
Erdheim–Chester disease (ECD) is an extremely rare disease classified as a non- Langerhans-cell histiocytic neoplasm. In 2016, the World Health Organization (WHO) defined ECD as a slow-growing blood cancer that may originate in the bone marrow or precursor cells. Typical onset occurs in middle aged individuals, although pediatric cases have been documented. The exact cause of ECD remains unknown, though it is believed to be linked to an exaggerated TH1 immune response. The disease involves an infiltration of lipid-laden macrophages, multi-nucleated giant cells, an inflammatory infiltrate of lymphocytes and histiocytes in the bone marrow, and a generalized sclerosis of the long bones. Signs and symptoms Erdheim-Chester disease can range from having no symptoms to being fatal, depending on how severe the disease is. It can cause symptoms like bone pain, heart problems, neurological issues, exophthalmos, and constitutional changes in health. Bone pain is the most common symptom, u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
