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Neuroborreliosis
Neuroborreliosis is a complication of Lyme Disease that affects the nervous system. 10 - 15% of patients with Lyme Disease develop Neuroborreliosis if left untreated. Neuroborreliosis is caused by a Borrelia bacteria-infected tick bite. History * 1922 – Two French physicians, Drs. Garin and Bujadoux describe a patient presenting with meningorediculitis, after an erythema migrans following a tick bite * A few years later (date unspecified), a German physician, Dr. Bannwarth encounters patients with similar symptoms * 1976 – Lyme Disease was recognized as an independent condition, following reports of a group of children in Lyme, Connecticut, presenting with what appeared like juvenile rheumatoid arthritis * 1981 – The bacteria responsible for eliciting Lyme Disease infection in the United States, Borrelia burgdorferi, is isolated Epidemiology and Demographics United States: Lyme Disease cases are highly concentrated in the Northeast and Midwest regions, with a single str ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paracellular Transport
Paracellular transport refers to the transfer of substances across an epithelium by passing through the intercellular space ''between'' the cells. It is in contrast to transcellular transport, where the substances travel ''through'' the cell, passing through both the apical membrane and basolateral membrane. The distinction has particular significance in renal physiology and intestinal physiology. Transcellular transport often involves energy expenditure whereas paracellular transport is unmediated and passive down a concentration gradient, or by osmosis (for water) and solvent drag for solutes. Paracellular transport also has the benefit that absorption rate is matched to load because it has no transporters that can be saturated. In most mammals, intestinal absorption of nutrients is thought to be dominated by transcellular transport, e.g., glucose is primarily absorbed via the SGLT1 transporter and other glucose transporters. Paracellular absorption therefore plays only a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcellular Transport
Transcellular transport involves the transportation of solutes by a cell ''through'' a cell. Transcellular transport can occur in three different ways active transport, passive transport, and transcytosis. Active Transport Active transport is the process of moving molecules from an area of low concentrations to an area of high concentration. There are two types of active transport, primary active transport and secondary active transport. Primary active transport uses adenosine triphosphate (ATP) to move specific molecules and solutes against its concentration gradient. Examples of molecules that follow this process are potassium K+, sodium Na+, and calcium Ca2+. A place in the human body where this occurs is in the intestines with the uptake of glucose. Secondary active transport is when one solute moves down the electrochemical gradient to produce enough energy to force the transport of another solute from low concentration to high concentration. An example of where this ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythema Migrans
Erythema migrans or erythema chronicum migrans is an expanding rash often seen in the early stage of Lyme disease, and can also (but less commonly) be caused by southern tick-associated rash illness (STARI). Page last reviewed: October 22, 2015 It can appear anywhere from one day to one month after a tick bite. This rash does not represent an allergic reaction to the bite, but rather an actual skin infection of one of the Lyme bacteria species Lyme disease microbiology, from the genus ''Borrelia''. The rash's name comes from Neo-Latin for "migrating redness." Lyme disease "Erythema migrans is the only manifestation of Lyme disease in the United States that is sufficiently distinctive to allow clinical diagnosis in the absence of laboratory confirmation." Often, but not always, mentions of a target lesion (bull's-eye lesion) are talking about erythema migrans. However, the appearance of erythema migrans can vary considerably: while some look like a bull's eye, in the U.S. most ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
