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Neural Noise
Neuronal noise or neural noise refers to the random intrinsic electrical fluctuations within neuronal networks. These fluctuations are not associated with encoding a response to internal or external stimuli and can be from one to two orders of magnitude. Most noise commonly occurs below a voltage-threshold that is needed for an action potential to occur, but sometimes it can be present in the form of an action potential; for example, stochastic oscillations in pacemaker neurons in suprachiasmatic nucleus are partially responsible for the organization of circadian rhythms. Background Neuronal activity at the microscopic level has a stochastic character, with atomic collisions and agitation, that may be termed "noise."Destexhe, A. (2012). ''Neuronal noise''. New York: Springer. While it isn't clear on what theoretical basis neuronal responses involved in perceptual processes can be segregated into a "neuronal noise" versus a "signal" component, and how such a proposed dichotomy could ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Third Law Of Thermodynamics
The third law of thermodynamics states that the entropy of a closed system at thermodynamic equilibrium approaches a constant value when its temperature approaches absolute zero. This constant value cannot depend on any other parameters characterizing the system, such as pressure or applied magnetic field. At absolute zero (zero kelvins) the system must be in a state with the minimum possible energy. Entropy is related to the number of accessible microstates, and there is typically one unique state (called the ground state) with minimum energy. In such a case, the entropy at absolute zero will be exactly zero. If the system does not have a well-defined order (if its order is glassy, for example), then there may remain some finite entropy as the system is brought to very low temperatures, either because the system becomes locked into a configuration with non-minimal energy or because the minimum energy state is non-unique. The constant value is called the residual entropy of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ganzfeld Effect
The Ganzfeld effect (from German for "complete field"), or perceptual deprivation, is a phenomenon of perception caused by exposure to an unstructured, uniform stimulation field. The effect is the result of the brain amplifying neural noise in order to look for the missing visual signals. The noise is interpreted in the higher visual cortex, and gives rise to hallucinations. It has been most studied with vision by staring at an undifferentiated and uniform field of color. The visual effect is described as the loss of vision as the brain cuts off the unchanging signal from the eyes. The result is "seeing black", an apparent sense of blindness. A flickering ganzfeld causes geometrical patterns and colors to appear, and this is the working principle for mind machines and the dream machine. Ganzfeld induction in multiple senses is called multi-modal ganzfeld. This is usually done by wearing ganzfeld goggles in addition to headphones with a uniform stimulus. A related effect is s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synaptic Noise
Synaptic noise refers to the constant bombardment of synaptic activity in neurons. This occurs in the background of a cell when potentials are produced without the nerve stimulation of an action potential, and are due to the inherently random nature of synapses. These random potentials have similar time courses as excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs), yet they lead to variable neuronal responses. The variability is due to differences in the discharge times of action potentials. Causes Many types of noise exist in cells. First, there is intrinsic noise and extrinsic, or synaptic, noise. Within each category there are two further divisions of noise – voltage noise or temporal noise. Intrinsic voltage noise is due to random changes in the membrane potential of a cell, and intrinsic temporal noise is caused by variations in spike generation timing. The following sections give explanations about the causes of synaptic noise. Quant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patch Clamp
The patch clamp technique is a laboratory technique in electrophysiology used to study ionic currents in individual Cell isolation, isolated living cells, tissue sections, or patches of cell membrane. The technique is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreas, pancreatic beta cells, and can also be applied to the study of bacterial ion channels in specially prepared giant spheroplasts. Patch clamping can be performed using the voltage clamp technique. In this case, the voltage across the cell membrane is controlled by the experimenter and the resulting currents are recorded. Alternatively, the Electrophysiology, current clamp technique can be used. In this case, the current passing across the membrane is controlled by the experimenter and the resulting changes in voltage are recorded, generally in the form of action potentials. Erwin Neher and Bert Sakmann developed the patch clamp in the late 1970s and earl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Local Field Potential
Local field potentials (LFP) are transient electrical signals generated in nerves and other tissues by the summed and synchronous electrical activity of the individual cells (e.g. neurons) in that tissue. LFP are "extracellular" signals, meaning that they are generated by transient imbalances in ion concentrations in the spaces outside the cells, that result from cellular electrical activity. LFP are 'local' because they are recorded by an electrode placed nearby the generating cells. As a result of the Inverse-square law, such electrodes can only 'see' potentials in a spatially limited radius. They are 'potentials' because they are generated by the voltage that results from charge separation in the extracellular space. They are 'field' because those extracellular charge separations essentially create a local electric field. LFP are typically recorded with a high-impedance microelectrode placed in the midst of the population of cells generating it. They can be recorded, for exa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bursting
Bursting, or burst firing, is an extremely diverse general phenomenon of the activation patterns of neurons in the central nervous system where periods of rapid action potential spiking are followed by quiescent periods much longer than typical inter-spike intervals. Bursting is thought to be important in the operation of robust central pattern generators, the transmission of neural codes, and some neuropathologies such as epilepsy. The study of bursting both directly and in how it takes part in other neural phenomena has been very popular since the beginnings of cellular neuroscience and is closely tied to the fields of neural synchronization, neural coding, plasticity, and attention. Observed bursts are named by the number of discrete action potentials they are composed of: a ''doublet'' is a two-spike burst, a ''triplet'' three and a ''quadruplet'' four. Neurons that are intrinsically prone to bursting behavior are referred to as ''bursters'' and this tendency to burst may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chaos Theory
Chaos theory is an interdisciplinary area of Scientific method, scientific study and branch of mathematics. It focuses on underlying patterns and Deterministic system, deterministic Scientific law, laws of dynamical systems that are highly sensitive to initial conditions. These were once thought to have completely random states of disorder and irregularities. Chaos theory states that within the apparent randomness of chaotic complex systems, there are underlying patterns, interconnection, constant feedback loops, repetition, self-similarity, fractals and self-organization. The butterfly effect, an underlying principle of chaos, describes how a small change in one state of a deterministic nonlinear system can result in large differences in a later state (meaning there is sensitive dependence on initial conditions). A metaphor for this behavior is that a butterfly flapping its wings in Brazil can cause or prevent a tornado in Texas. Text was copied from this source, which is avai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shot Noise
Shot noise or Poisson noise is a type of noise which can be modeled by a Poisson process. In electronics shot noise originates from the discrete nature of electric charge. Shot noise also occurs in photon counting in optical devices, where shot noise is associated with the particle nature of light. Origin In a statistical experiment such as tossing a fair coin and counting the occurrences of heads and tails, the numbers of heads and tails after many throws will differ by only a tiny percentage, while after only a few throws outcomes with a significant excess of heads over tails or vice versa are common; if an experiment with a few throws is repeated over and over, the outcomes will fluctuate a lot. From the law of large numbers, one can show that the relative fluctuations reduce as the reciprocal square root of the number of throws, a result valid for all statistical fluctuations, including shot noise. Shot noise exists because phenomena such as light and electric curren ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ion Channels
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, the other being ion transporters. The study of ion channels often involves biophysics, electrophysiology, and pharmacology, while using techniques including voltage clamp, patch clamp, immunohistochemistry, X-ray crystallography, fluoroscopy, and RT-PCR. Their classification as molecules is referred to as channelomics. Basic features There are two distinctive features of ion channels that differentiate them from other types of ion transporter proteins: # The rate of ion transport thr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sara Solla
Sara A. Solla is an Argentine-American physicist and neuroscientist whose research applies ideas from statistical mechanics to problems involving neural networks, machine learning, and neuroscience. She is a professor of physics and of physiology at Northwestern University. Education and career Solla is originally from Buenos Aires, and earned a licenciatura in physics in 1974 from the University of Buenos Aires. She completed a Ph.D. in physics in 1982 at the University of Washington. She became a postdoctoral researcher at Cornell University and at the Thomas J. Watson Research Center of IBM Research. Influenced to work in neural networks by a talk from John Hopfield at Cornell, she became a researcher in the neural networks group at Bell Labs. She took her present position at Northwestern University in 1997. Recognition Solla is a Member of the American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johnson–Nyquist Noise
Johnson–Nyquist noise (thermal noise, Johnson noise, or Nyquist noise) is the voltage or current noise generated by the thermal agitation of the charge carriers (usually the electrons) inside an electrical conductor at equilibrium, which happens regardless of any applied voltage. Thermal noise is present in all electrical circuits, and in sensitive electronic equipment (such as radio receivers) can drown out weak signals, and can be the limiting factor on sensitivity of electrical measuring instruments. Thermal noise is proportional to absolute temperature, so some sensitive electronic equipment such as radio telescope receivers are cooled to cryogenic temperatures to improve their signal-to-noise ratio. The generic, statistical physical derivation of this noise is called the fluctuation-dissipation theorem, where generalized impedance or generalized susceptibility is used to characterize the medium. Thermal noise in an ideal resistor is approximately white, meaning that it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
