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Natural History Group
The term natural history group refers to subjects in a drug trial that receive no treatment of any kind and whose illness is, as a consequence, left to run its "natural" course. The term stems from the natural history of an illness, which is the course and outcome of that illness in the absence of treatment. First usage In 1863, Austin Flint (1812–1886) in his report of the first-ever trial that directly compared the efficacy of a placebo treatment with that of an active treatment, spoke of "the natural history of n untreateddisease". Flint (1863), p.18. Third arm The natural history group is often referred to as the ''third arm'' of a controlled drug trial, from the simple notion that a trial constructed in this way has three, rather than two arms (the "active" and "placebo" groups). The observed outcomes within this group are then compared with the outcomes manifested by a group that has been given the active drug, and with that manifested by a second group who have been gi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural History Of Disease
The natural history of disease is the course a disease takes in individual people from its pathological onset ("inception") until its resolution (either through complete recovery or eventual death). The inception of a disease is not a firmly defined concept. The natural history of a disease is sometimes said to start at the moment of exposure to causal agents. Knowledge of the natural history of disease ranks alongside causal understanding in importance for disease prevention and control. Natural history of disease is one of the major elements of descriptive epidemiology. As an example, the cartilage of the knee, trapeziometacarpal and other joints deteriorates with age in most humans (osteoarthritis). There are no disease-modifying treatments for osteoarthritis---no way to slow, arrest, or reverse this pathophysiological process. There are only palliative/symptomatic treatments such as analgesics and exercises. In contrast, consider rheumatoid arthritis, a systemic inflammatory ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Austin Flint
Austin Flint I (October 20, 1812 – March 13, 1886) was an American physician. He was a founder of Buffalo Medical College, precursor to The State University of New York at Buffalo. He served as president of the American Medical Association. Biography Flint was born at Petersham, Massachusetts, on October 20, 1812, to Joseph Henshaw Flint (1786-1846) and Hannah Willard Reed. He was educated at Amherst and Harvard and graduated at the latter in 1833. After practicing at Boston, Massachusetts, and Northampton, Massachusetts, he moved to Buffalo, New York, in 1836. He was appointed professor of the institutes and practices of medicine in Rush Medical College in Chicago, Illinois; resigned after one year, in 1846, and established the ''Buffalo Medical Journal''. With Doctors White and Frank Hastings Hamilton he founded the Buffalo Medical College in 1847, where he was professor of the principles and practice of medicine for six years. He was afterward professor of the theory an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placebo
A placebo ( ) can be roughly defined as a sham medical treatment. Common placebos include inert tablets (like sugar pills), inert injections (like saline), sham surgery, and other procedures. Placebos are used in randomized clinical trials to test the efficacy of medical treatments. In a placebo-controlled trial, any change in the control group is known as the ''placebo response'', and the difference between this and the result of no treatment is the ''placebo effect''. Placebos in clinical trials should ideally be indistinguishable from so-called verum treatments under investigation, except for the latter's particular hypothesized medicinal effect. This is to shield test participants (with their consent) from knowing who is getting the placebo and who is getting the treatment under test, as patients' and clinicians' expectations of efficacy can influence results. The idea of a placebo effect was discussed in 18th century psychology, but became more prominent in the 20th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
