Mole (or Molé) may refer to:
Animals
* Mole (animal)
* "True moles" of the family Talpidie
* Golden mole, southern African mammals
* Marsupial mole, Australian mammals
* Mole-rat
Other common meanings
* Nevus, a growth on human skin
** Melanocytic nevus, a specific type of mole
* Mole (architecture), a structure separating bodies of water
* Mole (espionage), a spy in an organisation
* Mole (sauce), a traditional Mexican food which can be a sauce or marinade
* An abnormal mass within the uterus; see molar pregnancy
Arts and entertainment
* Mole, in the novel '' The Wind in the Willows'' by Kenneth Grahame
* Mole (Zdeněk Miler character)
* The Mole, in '' Happy Tree Friends''
* The Mole, a criminal in Dick Tracy comic strips
* '' El Topo'' (''The Mole''), a 1970 film
* ''De Mol'' (TV series)
* "The Mole", a song by Harry James
* ''Mole'' (video game), a 2026 psychological horror game
Science and technology
* Mole (unit), the SI unit for the amount of substa ...