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Mildronate
Meldonium (INN; trade name Mildronate, among others) is a pharmaceutical developed in 1970 by Ivars Kalviņš at the USSR Latvia Institute of Organic Synthesis. It is now manufactured by the Latvian pharmaceutical company Grindeks and various generic producers. Primarily distributed in Eastern Europe, meldonium is used as an anti-ischemia medication. Meldonium is prescribed for cardiovascular, neurological, and metabolic conditions due to its anti-ischaemic and cardioprotective effects, achieved by inhibiting β-oxidation and activating glycolysis. Athletes have used meldonium to enhance recovery and (controversially) performance, though these claims lack robust scientific support. Since 1 January 2016, meldonium has been listed as a banned substance by the World Anti-Doping Agency (WADA). It functions as a metabolic modulator, altering enzymatic reactions in the body. While some athletes, including Maria Sharapova, used meldonium before its ban, its effectiveness as a per ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gamma-butyrobetaine Dioxygenase
Gamma-butyrobetaine dioxygenase (also known as BBOX, GBBH or γ-butyrobetaine hydroxylase) is an enzyme that in humans is encoded by the ''BBOX1'' gene. Gamma-butyrobetaine dioxygenase catalyses the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthesis pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta oxidation. In humans, gamma-butyrobetaine dioxygenase can be found in the kidney (high), liver (moderate), and brain (very low). ''BBOX1'' has recently been identified as a potential cancer gene based on a large-scale microarray data analysis. Reaction Gamma-butyrobetaine dioxygenase belongs to the 2-oxoglutarate (2OG)-dependent dioxygenases, 2-oxoglutarate (2OG)-dependent dioxygenase superfamily. It catalyses the following reaction: :4-trimethylammoniobutanoate (γ-butyrobetaine) + 2-oxoglutarate + O2 \rightleftharpoons 3-hydroxy-4-trimethylammoniobutanoat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maria Sharapova
Maria Yuryevna Sharapova (, ; born 19 April 1987) is a Russian former professional tennis player. She was ranked as the world No. 1 in women's singles by the Women's Tennis Association (WTA) for 21 weeks. Sharapova won 36 WTA Tour-level singles titles, including five major titles, as well as the 2004 WTA Tour Championships. She is one of ten women to achieve the Career Grand Slam in singles. A teen sensation, Sharapova broke through to the top of the sport by winning the 2004 Wimbledon Championships as a 17-year-old, upsetting two-time defending champion Serena Williams. She then won the 2004 Tour Finals, and became the world No. 1 for the first time in August 2005 at the age of 18, the first Russian woman to top the singles rankings. Continued success over the following years, including titles at the 2006 US Open – Women's singles, 2006 US Open and 2008 Australian Open – Women's singles, 2008 Australian Open, was accompanied by recurring injuries, and Sharapova dip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grindeks
JSC Grindex (branded as ''Grindex''), or simply Grindeks, is an internationally operating Latvian pharmaceutical company with headquarters in Riga, Latvia. Its portfolio consists of original products, generics, and active pharmaceutical ingredients. It mostly focuses on cardiovascular, central nervous system, anti-cancer, and diabetes medicines. Grindex is the leading pharmaceutical manufacturer in the Baltic States. In 2021, Grindex exported products to more than 90 countries. Grindex Group consists of JSC Grindex and its four subsidiaries �JSC Kalceks(Latvia)HBM Pharma Ltd.(Slovakia)(Estonia) and ''Namu apsaimniekošanas projekti'' Ltd. (Latvia). History 1946–1990 * Grindex was founded in 1946 when its predecessor, the Vitamin and Hormones Plant, was transformed into an experimental plant to produce medicines. * In 1957, the Vitamin and Hormones Plant became part of the newly established Organic Synthesis Institute (OSI). The plant was developed as the OSI's experiment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatty Acid Oxidation Inhibitor
Fatty acid oxidation inhibitors are a new potent class of drugs used in treatment of stable angina pectoris and an addition in treatment of chronic heart failure. Drugs * CPT-I inhibitors: etomoxir, oxfenicine, perhexiline CPT-I ( carnitine palmitoyl transferase) converts fatty acyl-CoA to fatty acyl-carnitine. * Carnitine biosynthesis inhibitor: mildronate * 3-KAT inhibitors: trimetazidine 3-KAT ( 3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation In biochemistry and metabolism, beta oxidation (also β-oxidation) is the Catabolism, catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA. Acetyl .... * pFOX directly inhibits fatty acid beta-oxidation.Partial fatty acid oxidation inhibitors: a potentially new class of drugs for heart failure; European Journal of Heart Failure 4 2002. 3-6; http://eurjhf.oxfordjournals.org/content/4/1/3.full.pdf+ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reed Organ
The pump organ or reed organ is a type of organ that uses free reeds to generate sound, with air passing over vibrating thin metal strips mounted in a frame. Types include the pressure-based harmonium, the suction reed organ (which employs a vacuum system), and the Indian harmonium. Historical examples include the ''Kunstharmonium'' and the American reed organ, while earlier forms include the physharmonica and the seraphine. More portable than pipe organs, free-reed organs became widespread in smaller churches and private homes during the 19th century, although their volume and tonal range were limited. They generally featured one, or occasionally two, manuals, while pedal-boards were rare. Higher-end pump organs offered a broader range of tones, and models intended for churches or affluent households were often housed in finely crafted cabinets. Between the 1850s and the 1920s, several million reed organs and melodeons were manufactured in the United States and Canada ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dimethylamine
Dimethylamine is an organic compound with the formula (CH3)2NH. This secondary amine is a colorless, flammable gas with an ammonia-like odor. Dimethylamine is commonly encountered commercially as a solution in water at concentrations up to around 40%. An estimated 270,000 tons were produced in 2005. Structure and synthesis The molecule consists of a nitrogen atom with two methyl substituents and one hydrogen. Dimethylamine is a weak base and the pKa of the ammonium CH3--CH3 is 10.73, a value above methylamine (10.64) and trimethylamine (9.79). Dimethylamine reacts with acids to form salts, such as dimethylamine hydrochloride, an odorless white solid with a melting point of 171.5 °C. Dimethylamine is produced by catalytic reaction of methanol and ammonia at elevated temperatures and high pressure: : Natural occurrence Dimethylamine is found quite widely distributed in animals and plants, and is present in many foods at the level of a few mg/kg. Uses Dimethylamine is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stevens Rearrangement
The Stevens rearrangement in organic chemistry is an organic reaction converting quaternary ammonium salts and sulfonium salts to the corresponding amines or sulfides in presence of a strong base in a 1,2-rearrangement. The reactants can be obtained by alkylation of the corresponding amines and sulfides. The substituent R next the amine methylene bridge is an electron-withdrawing group. The original 1928 publication by Thomas S. Stevens concerned the reaction of ''1-phenyl-2-(N,N-dimethylamino)ethanone'' with benzyl bromide to the ammonium salt followed by the rearrangement reaction with sodium hydroxide in water to the rearranged amine. A 1932 publication described the corresponding sulfur reaction. Reaction mechanism The reaction mechanism of the Stevens rearrangement is one of the most controversial reaction mechanisms in organic chemistry. Key in the reaction mechanism for the Stevens rearrangement (explained for the nitrogen reaction) is the formation of an ylide afte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Half Maximal Inhibitory Concentration
Half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, ''in vitro'', a given biological process or biological component by 50%. The biological component could be an enzyme, cell, cell receptor or microbe. IC50 values are typically expressed as molar concentration. IC50 is commonly used as a measure of antagonist drug potency in pharmacological research. IC50 is comparable to other measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect ''in vivo''. IC50 can be determined with functional assays or with competition binding assays. Sometimes, IC50 values are converted to the pIC50 scale. :\ce = -\log_ \ce Due to the minus sign, higher values of pIC50 indicate ex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitochondria
A mitochondrion () is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. They were discovered by Albert von Kölliker in 1857 in the voluntary muscles of insects. The term ''mitochondrion'', meaning a thread-like granule, was coined by Carl Benda in 1898. The mitochondrion is popularly nicknamed the "powerhouse of the cell", a phrase popularized by Philip Siekevitz in a 1957 ''Scientific American'' article of the same name. Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells). The multicellular animal '' Henneguya salminicola'' is known to have retained mitochondrion-related organelles despite a complete loss of their mitochondrial genome. A large number of unicellular organisms, such as microspo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biosynthesis L-carnitine
Biosynthesis, i.e., chemical synthesis occurring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products. Examples of biosynthetic pathways include those for the production of amino acids, lipid membrane components, and nucleotides, but also for the production of all classes of biological macromolecules, and of acetyl-coenzyme A, adenosine triphosphate, nicotinamide adenine dinucleotide and other key intermediate and transactional molecules needed for metabolism. Thus, in biosynthesis, any of an array of compounds, from simple to complex, are converted into other compounds, and so it includes both the catabolism and anabolism (building up and breaking down) of complex molecules (including macromolecules). Biosynthetic processes are often ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Formaldehyde
Formaldehyde ( , ) (systematic name methanal) is an organic compound with the chemical formula and structure , more precisely . The compound is a pungent, colourless gas that polymerises spontaneously into paraformaldehyde. It is stored as aqueous solutions (formalin), which consists mainly of the hydrate CH2(OH)2. It is the simplest of the aldehydes (). As a precursor to many other materials and chemical compounds, in 2006 the global production of formaldehyde was estimated at 12 million tons per year. It is mainly used in the production of industrial resins, e.g., for particle board and coatings. Formaldehyde also occurs naturally. It is derived from the degradation of serine, dimethylglycine, and lipids. Demethylases act by converting N-methyl groups to formaldehyde. Formaldehyde is classified as a group 1 carcinogen and can cause respiratory and skin irritation upon exposure. Forms Formaldehyde is more complicated than many simple carbon compounds in that i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carnitine
Carnitine is a quaternary ammonium compound involved in metabolism in most mammals, plants, and some bacteria. In support of energy metabolism, carnitine transports long-chain fatty acids from the cytosol into mitochondria to be oxidized for free energy production, and also participates in removing products of metabolism from cells. Given its key metabolic roles, carnitine is concentrated in tissues like skeletal and cardiac muscle that metabolize fatty acids as an energy source. Generally individuals, including strict vegetarians, synthesize enough L-carnitine in vivo. Carnitine exists as one of two stereoisomers: the two enantiomers -carnitine (''S''-(+)-) and -carnitine (''R''-(−)-). Both are biologically active, but only -carnitine naturally occurs in animals, and -carnitine is toxic as it inhibits the activity of the -form. At room temperature, pure carnitine is a whiteish powder, and a water-soluble zwitterion with relatively low toxicity. Derived from amino acids, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
