Methylguanosine
Methylguanosine may refer to: * 1-Methylguanosine * 7-Methylguanosine 7-Methylguanosine (m7G) is a modified purine nucleoside. It is a methylated version of guanosine and when found in human urine, it may be a biomarker of some types of cancer. In the RNAs, 7-methylguanosine have been used to study and examine t ... {{Short pages monitor ...
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N1-Methylguanosine
N1-Methylguanosine (also 1-Methylguanosine or m1G) is a modified nucleoside, derived from guanosine through the addition of a methyl group to the nitrogen atom at position 1 of the guanine base. This modification results in a fixed positive charge on the purine ring. It occurs in all transfer RNAs (tRNAs) that read codons starting with C except in those tRNAs that read CAN codons. m1G can help prevent errors in protein synthesis, and lower levels can cause significant errors, reduction of protein output, and lower cell viability. Additionally, as a RNA component, it is excreted in urine and elevated levels may be usable as an indicator of certain cancers. Occurrence and function The most extensively studied function of m1G is in tRNA, where it is typically found at position 37 (m1G37), immediately 3' to the anticodon. This modification is critical for maintaining translational fidelity. The presence of m1G37, with its positive charge and steric bulk, helps prevent frameshift err ...
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