Methylamide
In biochemistry, an ''N''-methylamide (NME) is a blocking group for the C-terminus end of peptides. When the carboxyl In organic chemistry, a carboxylic acid is an organic acid that contains a carboxyl group () attached to an R-group. The general formula of a carboxylic acid is often written as or , sometimes as with R referring to an organyl group (e.g. ... group of the C-terminus is replaced with a methylamide, further elongation of the peptide chain is prevented. C-Terminal modified peptides are also useful for the modulation of structure-activity relationships and for modifying conformational properties of peptides. ''N''-Methylamides can be prepared directly from solid phase resin-bound peptides. References Carboxamides {{biochem-stub ...
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