Mannosidase

	Mannosidase Mannosidase is an enzyme which hydrolyses mannose. There are two types: * alpha-Mannosidase alpha-Mannosidase (, ''alpha-D-mannosidase'', ''p-nitrophenyl-alpha-mannosidase'', ''alpha-D-mannopyranosidase'', ''1,2-alpha-mannosidase'', ''1,2-alpha-D-mannosidase'', ''exo-alpha-mannosidase'') is an enzyme involved in the cleavage of the a ... * beta-Mannosidase A deficiency is associated with mannosidosis. A family of mannosidases are also responsible for processing newly formed glycoproteins in the endoplasmic reticulum into mature glycoproteins containing highly heterogeneous complex-type glycans. References EC 3.2.1 {{3.2-enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Alpha-Mannosidase alpha-Mannosidase (, ''alpha-D-mannosidase'', ''p-nitrophenyl-alpha-mannosidase'', ''alpha-D-mannopyranosidase'', ''1,2-alpha-mannosidase'', ''1,2-alpha-D-mannosidase'', ''exo-alpha-mannosidase'') is an enzyme involved in the cleavage of the alpha form of mannose. Its systematic name is ''alpha-D-mannoside mannohydrolase''. Isozymes Humans express the following three alpha-mannosidase isozymes In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. Isozymes usually have different kinetic parameters (e.g. dif ...: Applications It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development. Pathology A deficiency can lead to alpha-mannosidosis. References External links GeneReviews/NCBI/NIH/UW entry on Alpha-Mann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Mannose Mannose is a sugar monomer of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. Mannose is important in human metabolism, especially in the glycosylation of certain proteins. Several congenital disorders of glycosylation are associated with mutations in enzymes involved in mannose metabolism. Mannose is not an essential nutrient; it can be produced in the human body from glucose, or converted into glucose. Mannose provides 2–5 kcal/g. It is partially excreted in the urine. Etymology The root of both "mannose" and "mannitol" is manna, which the Bible describes as the food supplied to the Israelites during their journey in the region of Sinai. Several trees and shrubs can produce a substance called manna, such as the "manna tree" ('' Fraxinus ornus'') from whose secretions mannitol was originally isolated. Structure Mannose commonly exists as two different-sized rings, the pyranose (six-membered) form and the furanose (five-membered) form. Eac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Beta-Mannosidase Beta-mannosidase (, ''mannanase'', ''mannase'', ''beta-D-mannosidase'', ''beta-mannoside mannohydrolase'', ''exo-beta-D-mannanase'', ''lysosomal beta A mannosidase'') is an enzyme with systematic name ''beta-D-mannoside mannohydrolase'', which is in humans encoded by the ''MANBA'' gene. This enzyme catalyses the following chemical reaction A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and break ... : Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Mannosidosis Mannosidosis is a deficiency in mannosidase, an enzyme. There are two types: * Alpha-mannosidosis * Beta-mannosidosis See also Swainsonine Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. As a toxin in locoweed (likely its primary toxin) it also is a significant cause of econo ... References {{Glycoproteinoses Glycoprotein metabolism disorders ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]