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Macroautophagy
Autophagy (or autophagocytosis; from the Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. It allows the orderly degradation and recycling of cellular components. Although initially characterized as a primordial degradation pathway induced to protect against starvation, it has become increasingly clear that autophagy also plays a major role in the homeostasis of non-starved cells. Defects in autophagy have been linked to various human diseases, including neurodegeneration and cancer, and interest in modulating autophagy as a potential treatment for these diseases has grown rapidly. Four forms of autophagy have been identified: macroautophagy, microautophagy, chaperone-mediated autophagy (CMA), and crinophagy. In macroautophagy (the most thoroughly researched form of autophagy), cytoplasmic components (like mitochon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysosome
A lysosome () is a membrane-bound organelle that is found in all mammalian cells, with the exception of red blood cells (erythrocytes). There are normally hundreds of lysosomes in the cytosol, where they function as the cell’s degradation center. Their primary responsibility is catabolic degradation of proteins, polysaccharides and lipids into their respective building-block molecules: amino acids, monosaccharides, and free fatty acids. The breakdown is done by various enzymes, for example proteases, glycosidases and lipases. With an acidic lumen limited by a single-bilayer lipid membrane, the lysosome holds an environment isolated from the rest of the cell. The lower pH creates optimal conditions for the over 60 different Hydrolase, hydrolases inside. Lysosomes receive extracellular particles through endocytosis, and intracellular components through autophagy. They can also fuse with the plasma membrane and secrete their contents, a process called lysosomal exocytosis. After ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chaperone-mediated Autophagy
Chaperone-mediated autophagy (CMA) refers to the chaperone-dependent selection of soluble cytosolic proteins that are then targeted to lysosomes and directly translocated across the lysosome membrane for degradation. The unique features of this type of autophagy are the selectivity on the proteins that are degraded by this pathway and the direct shuttling of these proteins across the lysosomal membrane without the requirement for the formation of additional vesicles (Figure 1). Molecular components and steps The proteins that are degraded through CMA are cytosolic proteins or proteins from other compartments once they reach the cytosol. Therefore, some of the components that participate in CMA are present in the cytosol while others are located at the lysosomal membrane (Table I). Specific selection of proteins for degradation in all forms of autophagy came to further understanding as studies discovered the role of chaperones like hsc70. Although hsc70 targets cytosolic protein to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autolysis (biology)
In biology, autolysis, more commonly known as self-digestion, refers to the destruction of a cell through the action of its own enzymes. It may also refer to the digestion of an enzyme by another molecule of the same enzyme. The term derives from the Greek αὐτο- 'self' and λύσις 'splitting'. Biochemical mechanisms of cell destruction Autolysis is uncommon in living adult organisms and usually occurs in necrotic tissue as enzymes act on components of the cell that would not normally serve as substrates. These enzymes are released due to the cessation of active processes in the cell that provide substrates in healthy, living tissue; autolysis in itself is not an active process. In other words, though autolysis resembles the active process of digestion of nutrients by live cells, the dead cells are not actively digesting themselves as is often claimed, and as the synonym self-digestion suggests. Failure of respiration and subsequent failure of oxidative phosphorylation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alex B
This is a list of available actual and physical albums belonging to the official 1983 ''Now That's What I Call Music!'' UK series, comprising: compact discs (CD), magnetic audio cassettes (AC), vinyl ( LP), VHS tape, DVD and on other short-lived formats. They are categorized by series (country), then ordered by date. All countries have discontinued their respective series, with the only exception being the United Kingdom. United Kingdom and Ireland The evolution of ''Now That's What I Call Music!'' in the UK reflects the changing landscape of music consumption formats. Starting from vinyl and magnetic audio cassettes, the series adapted to the rise of compact discs (CDs) and explored various formats like DVDs, MiniDiscs, and videos. Music formats The initial releases of ''Now That's What I Call Music!'' in the UK were exclusively on vinyl and magnetic audio cassette formats. Compact discs (CD) * The series transitioned to CD with the release of ''Now That's What I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrolytic Enzymes
In biochemistry, hydrolases constitute a class of enzymes that commonly function as biochemical catalysts that use water to break a chemical bond: :\ce \quad \xrightarrowtext\quad \ce This typically results in dividing a larger molecule into smaller molecules. Some common examples of hydrolase enzymes are esterases including lipases, phosphatases, glycosidases, peptidases, and nucleosidases. Esterases cleave ester bonds in lipids and phosphatases cleave phosphate groups off molecules. An example of crucial esterase is acetylcholine esterase, which assists in transforming the neuron impulse into the acetate group after the hydrolase breaks the acetylcholine into choline and acetic acid. Acetic acid is an important metabolite in the body and a critical intermediate for other reactions such as glycolysis. Lipases hydrolyze glycerides. Glycosidases cleave sugar molecules off carbohydrates and peptidases hydrolyze peptide bonds. Nucleosidases hydrolyze the bonds of nucleotides. Hyd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yeast
Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom (biology), kingdom. The first yeast originated hundreds of millions of years ago, and at least 1,500 species are currently recognized. They are estimated to constitute 1% of all described fungal species. Some yeast species have the ability to develop multicellular characteristics by forming strings of connected budding cells known as pseudohyphae or false hyphae, or quickly evolve into a Multicellular organism, multicellular cluster with specialised Organelle, cell organelles function. Yeast sizes vary greatly, depending on species and environment, typically measuring 3–4 micrometre, μm in diameter, although some yeasts can grow to 40 μm in size. Most yeasts reproduce asexual reproduction, asexually by mitosis, and many do so by the asymmetric division process known as budding. With their single-celled growth habit, yeasts can be contrasted with Mold (fungus), molds, wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daniel J
Daniel commonly refers to: * Daniel (given name), a masculine given name and a surname * List of people named Daniel * List of people with surname Daniel * Daniel (biblical figure) * Book of Daniel, a biblical apocalypse, "an account of the activities and visions of Daniel" Daniel may also refer to: Arts and entertainment Literature * ''Daniel'' (Old English poem), an adaptation of the Book of Daniel * ''Daniel'', a 2006 novel by Richard Adams * ''Daniel'' (Mankell novel), 2007 Music * "Daniel" (Bat for Lashes song) (2009) * "Daniel" (Elton John song) (1973) * "Daniel", a song from '' Beautiful Creature'' by Juliana Hatfield * ''Daniel'' (album), a 2024 album by Real Estate Other arts and entertainment * ''Daniel'' (1983 film), by Sidney Lumet * ''Daniel'' (2019 film), a Danish film * Daniel (comics), a character in the ''Endless'' series Businesses * Daniel (department store), in the United Kingdom * H & R Daniel, a producer of English porcelain between 1827 and 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keystone Symposia
Keystone Symposia on Molecular and Cellular Biology or Keystone Symposia is an internationally recognized nonprofit organization that annually hosts 50–60 conferences and symposia covering a range of research fields in the life sciences and biomedical sciences. Most conferences are held in westward mountain venues in North America but conferences are held on six continents. The organization also hosts the annual Fellows Program for postdocs and early-career scientists from disadvantaged or underrepresented backgrounds. The 50th anniversary of Keystone Symposia occurred in 2022. History Believed to be inspired by European conferences located at ski resorts, Keystone was founded by C. Fred Fox, a professor of microbiology in the Molecular Biology Institute at University of California, Los Angeles (UCLA), with sponsorship from International Chemical and Nuclear Pharmaceuticals (ICN). The organization was named the ICN-UCLA Symposium on Molecular Biology and held its first confere ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autophagy (journal)
''Autophagy'' is a monthly peer-reviewed scientific journal covering all aspects of cell autophagy. It is published by Taylor & Francis and the editor-in-chief is Daniel J. Klionsky (University of Michigan). Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor of 16.016 and a five-year impact factor of 16.586 (2020) . See also *Nature Communications *PNAS * Traffic Journal *'' Cell Biology International'' *''Cell and Tissue Research ''Cell and Tissue Research'' presents regular articles and reviews in the areas of molecular, cell, stem cell biology and tissue engineering. In particular, the journal provides a forum for publishing data that analyze the supracellular, integrati ...'' * ''Cell Cycle'' References External links * Molecular and cellular biology journals Academic journals established in 2005 English-language journals Taylor & Francis academic journals Monthly j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glucagon
Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It raises the concentration of glucose and fatty acids in the bloodstream and is considered to be the main catabolic hormone of the body. It is also used as a Glucagon (medication), medication to treat a number of health conditions. Its effect is opposite to that of insulin, which lowers extracellular glucose. It is produced from proglucagon, encoded by the ''GCG'' gene. The pancreas releases glucagon when the amount of glucose in the bloodstream is too low. Glucagon causes the liver to engage in glycogenolysis: converting stored glycogen into glucose, which is released into the bloodstream. High blood-glucose levels, on the other hand, stimulate the release of insulin. Insulin allows glucose to be taken up and used by insulin-dependent tissues. Thus, glucagon and insulin are part of a feedback system that keeps blood glucose levels stable. Glucagon increases energy expenditure and is elevated under conditions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
