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Ixoberogene Soroparvovec
Ixoberogene soroparvovec (, also known as ADVM-022), is a gene therapy developed by Adverum Biotechnologies Adverum Biotechnologies, Inc., formerly known as Avalanche Biotechnologies, is a publicly traded clinical stage gene therapy company located in Redwood City, California. The company is targeting unmet medical needs for serious ocular and rare disea ... for wet age-related macular degeneration. It is delivered via the viral vector AAV.7m8. References {{reflist Experimental gene therapies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adverum Biotechnologies
Adverum Biotechnologies, Inc., formerly known as Avalanche Biotechnologies, is a publicly traded clinical stage gene therapy company located in Redwood City, California. The company is targeting unmet medical needs for serious ocular and rare diseases, including wet age-related macular degeneration (wet AMD). History Avalanche Biotechnologies was founded in 2006 by Tom Chalberg, Mark Blumenkranz, Mitchell Finer, and Steven Schwartz. Avalanche went public through an IPO in 2014, raising $102 million. In 2015, co-founder Tom Chalberg stepped down as CEO following Phase IIa trial results that were labeled as "iffy". In May 2016, Avalanche acquired Annapurna Therapeutics and changed its name to Adverum Biotechnologies. It also changed its ticker symbol on the Nasdaq exchange from AAVL to ADVM. In October 2016, former Annapurna Therapeutics CEO Amber Salzman became CEO of Adverum. In May 2018, CEO Amber Salzman left Adverum, and Chief Medical Officer Athena Countouriotis resigned ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wet Age-related Macular Degeneration
Macular degeneration, also known as age-related macular degeneration (AMD or ARMD), is a medical condition which may result in blurred or no vision in the center of the visual field. Early on there are often no symptoms. Some people experience a gradual worsening of vision that may affect one or both eyes. While it does not result in complete blindness, loss of central vision can make it hard to recognize faces, drive, read, or perform other activities of daily life. Visual hallucinations may also occur. Macular degeneration typically occurs in older people, and is caused by damage to the macula of the retina. Genetic factors and smoking may play a role. The condition is diagnosed through a complete eye exam. Severity is divided into early, intermediate, and late types. The late type is additionally divided into "dry" and "wet" forms, with the dry form making up 90% of cases. The difference between the two forms is categorized by the change in the macula. Those with dry-fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
