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Indolocarbazole
Indolocarbazoles (ICZs) are a class of compounds that are under current study due to their potential as anti-cancer as well as antimicrobial drugs and the prospective number of derivatives and uses found from the basic backbone alone. First isolated in 1977, a wide range of structures and derivatives have been found or developed throughout the world. Due to the extensive number of structures available, this review will focus on the more important groups here while covering their occurrence, biological activity, biosynthesis, and laboratory synthesis. Chemical classification Indolocarbazoles belong to the alkaloid sub-class of bisindoles. The most frequently isolated indolocarbazoles are Indolo(2,3-a)carbazoles; the most common subgroup of the Indolo(2,3-a)carbazoles are the Indolo(2,3-a)pyrrole(3,4-c)carbazoles. These can be divided into two major classes - halogenated (chlorinated) with a fully oxidized C-7 carbon with only one indole nitrogen containing a β-glycosidic bond an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Staurosporine
Staurosporine (antibiotic AM-2282 or STS) is a natural product originally isolated in 1977 from the bacterium '' Streptomyces staurosporeus''. It was the first of over 50 alkaloids that were discovered to share this type of bis-indole chemical structure. The chemical structure of staurosporine was elucidated by X-ray crystalography in 1994. Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive. The interest in these activities resulted in a large investigative effort in chemistry and biology and the discovery of the potential for anti-cancer treatment. Biological activities The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, thou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rebeccamycin
Rebeccamycin (NSC 655649) is a weak topoisomerase I inhibitor isolated from ''Nocardia'' bacteria. It is structurally similar to staurosporine, but does not show any inhibitory activity against protein kinases. It shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity. Purpose The screening procedure is called the NCI- ... leukemia cells). It is an antineoplastic antibiotic and an intercalating agent. Becatecarin (BMS-181176) is a synthetic analog of rebeccamycin. Rebeccamycin and becatecarin have been tested in phase II clinical trials for the treatment of lung cancer, liver cancer, breast cancer, lymphoma, retinoblastoma, kidney cancer, and ovarian cancer. References Further reading * * * * * Experiment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myxomycete
Myxogastria/Myxogastrea (myxogastrids, ICZN) or Myxomycetes ( ICN) is a class of slime molds that contains 5 orders, 14 families, 62 genera, and 888 species. They are colloquially known as the ''plasmodial'' or ''acellular'' slime moulds. All species pass through several very different morphologic phases, such as microscopic individual cells, slimy amorphous organisms visible with the naked eye, and conspicuously shaped fruit bodies. Although they are monocellular, they can reach immense widths and weights: in extreme cases they can be up to across and weigh up to . The class Myxogastria is distributed worldwide, but it is more common in temperate regions where it has a higher biodiversity than in polar regions, the subtropics, or the tropics. They are mainly found in open forests, but also in extreme regions such as deserts, under snow blankets, or underwater. They also occur on the bark of trees, sometimes high in the canopy. These are known as corticolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Kinase
A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them ( phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a functional change of the target protein ( substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. There are two main types of protein kinase. The great majority are serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets. Most of the others are tyrosine kinases, although additional types exist. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction. Chemical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sponge
Sponges or sea sponges are primarily marine invertebrates of the animal phylum Porifera (; meaning 'pore bearer'), a basal clade and a sister taxon of the diploblasts. They are sessile filter feeders that are bound to the seabed, and are one of the most ancient members of macrobenthos, with many historical species being important reef-building organisms. Sponges are multicellular organisms consisting of jelly-like mesohyl sandwiched between two thin layers of cells, and usually have tube-like bodies full of pores and channels that allow water to circulate through them. They have unspecialized cells that can transform into other types and that often migrate between the main cell layers and the mesohyl in the process. They do not have complex nervous, digestive or circulatory systems. Instead, most rely on maintaining a constant water flow through their bodies to obtain food and oxygen and to remove wastes, usually via flagella movements of the so-called " collar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flatworm
Platyhelminthes (from the Greek language, Greek πλατύ, ''platy'', meaning "flat" and ἕλμινς (root: ἑλμινθ-), ''helminth-'', meaning "worm") is a Phylum (biology), phylum of relatively simple bilaterian, Segmentation (biology), unsegmented, soft-bodied invertebrates commonly called flatworms or flat worms. Being acoelomates (having no coelom, body cavity), and having no specialised circulatory system, circulatory and respiratory system, respiratory organ (anatomy), organs, they are restricted to having flattened shapes that allow oxygen and nutrients to pass through their bodies by diffusion. The digestive cavity has only one opening for both ingestion (intake of nutrients) and egestion (removal of undigested wastes); as a result, the food can not be processed continuously. In traditional medicinal texts, Platyhelminthes are divided into Turbellaria, which are mostly non-parasitic animals such as planarians, and three entirely parasitic groups: Cestoda, Trematod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mollusca
Mollusca is a phylum of protostome, protostomic invertebrate animals, whose members are known as molluscs or mollusks (). Around 76,000 extant taxon, extant species of molluscs are recognized, making it the second-largest animal phylum after Arthropoda. The number of additional fossil species is estimated between 60,000 and 100,000, and the proportion of undescribed species is very high. Many taxa remain poorly studied. Molluscs are the largest marine biology, marine phylum, comprising about 23% of all the named marine organisms. They are highly diverse, not just in size and anatomical structure, but also in behaviour and habitat, as numerous groups are freshwater mollusc, freshwater and even terrestrial molluscs, terrestrial species. The phylum is typically divided into 7 or 8 taxonomy (biology), taxonomic class (biology), classes, of which two are entirely extinct. Cephalopod molluscs, such as squid, cuttlefish, and octopuses, are among the most neurobiology, neurologi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tunicate
Tunicates are marine invertebrates belonging to the subphylum Tunicata ( ). This grouping is part of the Chordata, a phylum which includes all animals with dorsal nerve cords and notochords (including vertebrates). The subphylum was at one time called Urochordata, and the term urochordates is still sometimes used for these animals. Despite their simple appearance and very different adult form, their close relationship to the vertebrates is certain. Both groups are chordates, as evidenced by the fact that during their mobile larval stage, tunicates possess a notochord, a hollow dorsal nerve cord, pharyngeal slits, post-anal tail, and an endostyle. They resemble a tadpole. Tunicates are the only chordates that have lost their Myomere, myomeric segmentation, with the possible exception of the seriation of the gill slits. However, Doliolida, doliolids still display segmentation of the muscle bands. Some tunicates live as solitary individuals, but others replicate by budding and be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fischerella
''Fischerella'' is a genus of cyanobacteria belonging to the family Hapalosiphonaceae. The genus was first described by M. Gomont in 1895. The genus has cosmopolitan distribution. The genus name of ''Deightoniella'' is in honour of Christian Fischer (1801–1892), who was a Bohemian scientist and industrialist from Karlsbad (Baden). The genus was circumscribed In geometry, a circumscribed circle for a set of points is a circle passing through each of them. Such a circle is said to ''circumscribe'' the points or a polygon formed from them; such a polygon is said to be ''inscribed'' in the circle. * Circum ... by Jean-Baptiste Édouard Bornet and Charles Henri Marie Flahault in J. Bot. (Morot) Vol.9 on pages 51-52 in 1895. Known species: * '' Fischerella major'' * '' Fischerella muscicola'' References {{Taxonbar, from=Q27438671 Nostocales Cyanobacteria genera ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vero Beach, Florida
Vero Beach is a city in and the county seat of Indian River County, Florida, United States. According to the 2020 United States census, 2020 census, the city had a population of 16,354. Nicknamed "The Hibiscus City", Vero is situated about southeast of Orlando, Florida, Orlando along the Indian River Lagoon and the Atlantic Ocean on Florida's Treasure Coast. Because it is located about north of West Palm Beach, Florida, West Palm Beach at the northern end of the South Florida region, the city has adopted two similar mottos "The Gateway to the Tropics" and "Where the Tropics Begin". Vero Beach was named the 7th Best Small Beach Town in Florida by ''Southern Living Magazine'' in 2023. The main roadways in the city are U.S. Route 1, Florida State Road A1A, and Florida State Road 60 (20th Street), which has its eastern terminus at Sexton Plaza in the city. History Pre-Columbian Parts of a human skeleton were found north of Vero in association with the remains of Pleistocene animal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
