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Illudin
The illudins are a family of sesquiterpenes with antitumor antibiotic properties produced by some mushrooms. In their isolated form, illudins show selective toxicity for myelocytic leukemia and other carcinoma cells. Illudins are highly toxic, with little apparent therapeutic value in their natural form. Illudins are thought to be responsible for the toxicity of various ''Omphalotus ''Omphalotus'' is a genus of basidiomycete mushroom, in the family Omphalotaceae, formally circumscription (taxonomy), circumscribed by Victor Fayod in 1889. Members have the traditional pileus (mycology), cap and stipe (mycology), stem structu ...'' species such as '' O. olearius'' and '' O. illudens'' (Jack o' Lantern mushrooms), and '' O. nidiformis'' (Australian ghost fungus). Active metabolites of illudins damage DNA via an unknown mechanism. In addition, genetic analysis suggests that the illudin-mediated DNA damage is ignored by global excision repair systems unless the lesions occur within ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Omphalotus Illudens
''Omphalotus illudens'', commonly known as the eastern jack-o'lantern mushroom, is a North American species of fungus. Description It forms a large, orange mushroom. The caps grow up to wide. The gills are decurrent and the stem is up to 15 cm long. The flesh is orange and the spore print is white to cream. Its gills often exhibit a weak green bioluminescence when fresh. This green glow has been mentioned in several journal articles, which state that the phenomenon can persist up to 40–50 hours after the mushroom has been picked. It is believed that this display serves to attract insects to the mushroom's gills at night, which can then distribute its spores across a wider area. Similar species ''Omphalotus'' ''lludens'' is replaced by ''O. subilludens'' on the Gulf Coast, and ''O. olivascens'' is found in California. ''Armillaria tabescens'' forms small, dull orange caps. ''Omphalotus illudens'' is sometimes confused with edible chanterelles, but can be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Omphalotus Nidiformis
''Omphalotus nidiformis'', or ghost fungus, is a gilled basidiomycete mushroom most notable for its bioluminescent properties. It is known to be found primarily in southern Australia and Tasmania, but was reported from India in 2012 and 2018. The fan or funnel shaped fruit bodies are up to across, with cream-coloured caps overlain with shades of orange, brown, purple, or bluish-black. The white or cream gills run down the length of the stipe, which is up to long and tapers in thickness to the base. The fungus is both saprotrophic and parasitic, and its fruit bodies are generally found growing in overlapping clusters on a wide variety of dead or dying trees. First described scientifically in 1844, the fungus has been known by several names in its taxonomic history. It was assigned its current name by Orson K. Miller, Jr. in 1994. Its epithet name is derived from the Latin ''nidus'' "nest", hence 'nest shaped'. Similar in appearance to the common edible oyster mushroom, it w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Illudin Family
The illudins are a family of sesquiterpenes with antitumor antibiotic properties produced by some mushrooms. In their isolated form, illudins show selective toxicity for myelocytic leukemia and other carcinoma cells. Illudins are highly toxic, with little apparent therapeutic value in their natural form. Illudins are thought to be responsible for the toxicity of various ''Omphalotus ''Omphalotus'' is a genus of basidiomycete mushroom, in the family Omphalotaceae, formally circumscription (taxonomy), circumscribed by Victor Fayod in 1889. Members have the traditional pileus (mycology), cap and stipe (mycology), stem structu ...'' species such as '' O. olearius'' and '' O. illudens'' (Jack o' Lantern mushrooms), and '' O. nidiformis'' (Australian ghost fungus). Active metabolites of illudins damage DNA via an unknown mechanism. In addition, genetic analysis suggests that the illudin-mediated DNA damage is ignored by global excision repair systems unless the lesions occur within ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Omphalotus Olearius
''Omphalotus olearius'', commonly known as the jack-o'-lantern mushroom, is a poisonous orange gilled mushroom that to an untrained eye appears similar to some chanterelles. It is notable for its bioluminescent properties. It is found in woodland areas in Europe, where it grows on decaying stumps, on buried roots or at the base of hardwood trees. A similar, but phylogenetically distinct species found in eastern North America is '' Omphalotus illudens''. Unlike chanterelles, ''Omphalotus olearius'' and other ''Omphalotus'' species contain the toxin illudin S, and are poisonous to humans. While not typically lethal, consuming this mushroom leads to very severe cramps, vomiting, and diarrhea. Description ''Omphalotus olearius'' is the same shade of orange internally and externally. It does not change color when bruised or sliced, a feature which helps to distinguish it from visibly similar species. Its bioluminescence, a blue-green color, can be observed in fresh specimens in l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Omphalotus
''Omphalotus'' is a genus of basidiomycete mushroom, in the family Omphalotaceae, formally circumscription (taxonomy), circumscribed by Victor Fayod in 1889. Members have the traditional pileus (mycology), cap and stipe (mycology), stem structure. They are saprobic, and fruit in clumps on the ground, adjacent to host trees. The best known and type species is the jack-o'-lantern mushroom ''(Omphalotus olearius)''. Species of ''Omphalotus'' have been mistaken for Cantharellus, chanterelles. All ''Omphalotus'' species are presumed poisonous mushroom, poisonous, causing gastrointestinal symptoms. Some ''Omphalotus'' species have bioluminescent properties. Taxonomy Victor Fayod originally erected the genus with ''Omphalotus olearius, Pleurotus olearius'' and ''Pleurotus eryngii, P. eryngii'' as its principal species in 1889, placing it in a ''tribus'' ("alliance") with the genera ''Pleurotus'' and ''Pleurotellus''. The relationships of the genus have become clearer with geneti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mushroom
A mushroom or toadstool is the fleshy, spore-bearing Sporocarp (fungi), fruiting body of a fungus, typically produced above ground on soil or another food source. ''Toadstool'' generally refers to a poisonous mushroom. The standard for the name "mushroom" is the cultivated white button mushroom, ''Agaricus bisporus''; hence, the word "mushroom" is most often applied to those fungi (Basidiomycota, Agaricomycetes) that have a stem (Stipe (mycology), stipe), a cap (Pileus (mycology), pileus), and gills (lamellae, sing. Lamella (mycology), lamella) on the underside of the cap. "Mushroom" also describes a variety of other gilled fungi, with or without stems; therefore the term is used to describe the fleshy fruiting bodies of some Ascomycota. The gills produce microscopic Spore#Fungi, spores which help the fungus spread across the ground or its occupant surface. Forms deviating from the standard Morphology (biology), morphology usually have more specific names, such as "bolete", " ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leukemia
Leukemia ( also spelled leukaemia; pronounced ) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or '' leukemia cells''. Symptoms may include bleeding and bruising, bone pain, fatigue, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy. The exact cause of leukemia is unknown. A combination of genetic factors and environmental (non-inherited) factors are believed to play a role. Risk factors include smoking, ionizing radiation, petrochemicals (such as benzene), prior chemotherapy, and Down syndrome. People with a family history of leukemia are also at higher risk. There are four main types of leukemia—acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myelo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carcinoma
Carcinoma is a malignancy that develops from epithelial cells. Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal or ectodermal germ layer during embryogenesis. Carcinomas occur when the DNA of a cell is damaged or altered and the cell begins to grow uncontrollably and becomes malignant. It is from the (itself derived from meaning ''crab''). Classification As of 2004, no simple and comprehensive classification system has been devised and accepted within the scientific community. Traditionally, however, malignancies have generally been classified into various types using a combination of criteria, including: The cell type from which they start; specifically: * Epithelial cells ⇨ carcinoma * Non-hematopoietic mesenchymal cells ⇨ sarcoma * Hematopoietic cells ** Bone marrow–derived cells that normally mature in the bloodstream ⇨ leuke ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Organic Chemistry
''The Journal of Organic Chemistry'', colloquially known as ''JOC'', is a peer-reviewed scientific journal for original contributions of fundamental research in all branches of theory and practice in organic and bioorganic chemistry. It is published by the publishing arm of the American Chemical Society, with 24 issues per year. According to the ''Journal Citation Reports'', the journal had a 2023 impact factor of 3.3 and it is the journal that received the most cites (100,091 in 2017) in the field of organic chemistry. According to Web of Knowledge (and as December 2012), eleven papers from the journal have received more than 1,000 citations, with the most cited paper having received 7,967 citations. The current editor-in-chief is Scott J. Miller from Yale University. Indexing ''J. Org. Chem.'' is currently indexed in: See also * Organic Letters *Organometallics ''Organometallics'' is a biweekly journal published by the American Chemical Society. Its area of focus is o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sesquiterpene
Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many combinations. Biochemical modifications such as oxidation or rearrangement produce the related sesquiterpenoids. It is estimated (2006) that 3000 sesquiterpenes have been identified. Biosynthesis and examples The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate (FPP), which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. Cyclic sesquiterpenes are more common than cyclic monoterpenes because of the increased chain length and additional double bond in the sesquiterpene precursors. In addition to common six-membered ring systems such as the ones found in zingiberene and bisacurone, cyclization of one end of the chain to the other end can lead to macrocyclic rings such as humulene. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy, treatment and antibiotic prophylaxis, prevention of such infections. They may either bactericide, kill or bacteriostatic agent, inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the ones which cause the common cold or influenza. Drugs which inhibit growth of viruses are termed antiviral drugs or antivirals. Antibiotics are also not effective against fungi. Drugs which inhibit growth of fungi are called antifungal drugs. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek language, Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleotide Excision Repair
Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. Intercalation (biochemistry), intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize Base excision repair#Lesions processed by BER, specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by Base excision repair#DNA glycosylases, specific glycosylases. Similarly, the MMR pathway only targets mismatched Watson-Crick base pairs. Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
