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Hyoscyamine
Hyoscyamine (also known as daturine or duboisine) is a naturally occurring tropane alkaloid and plant toxin. It is a secondary metabolite found in certain plants of the family Solanaceae, including Hyoscyamus niger, henbane, Mandragora officinarum, mandrake, Brugmansia, angel's trumpets, Datura stramonium, jimsonweed, Latua pubiflora, the sorcerers' tree, and Atropa belladonna (deadly nightshade). It is the levorotary isomer of atropine (third of the three major nightshade alkaloids) and thus sometimes known as levo-atropine. In 2021, it was the 272nd most commonly prescribed medication in the United States, with more than 900,000 prescriptions. Medical uses Hyoscyamine is used to provide symptomatic relief of spasms caused by various lower abdominal and bladder disorders including peptic ulcers, irritable bowel syndrome, diverticulitis, pancreatitis, colic, and interstitial cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tropane Alkaloid
Tropane alkaloids are a class of bicyclic .2.1alkaloids and secondary metabolites that contain a tropane ring in their chemical structure. Tropane alkaloids occur naturally in many members of the plant family Solanaceae. Certain tropane alkaloids such as cocaine and scopolamine are notorious for their psychoactive effects, related usage and cultural associations. Particular tropane alkaloids such as these have pharmacological properties and can act as anticholinergics or stimulants. Classification Anticholinergics Anticholinergic drugs and deliriants: * Atropine, racemic hyoscyamine, from the deadly nightshade (''Atropa belladonna'') * Hyoscyamine, the ''levo''-isomer of atropine, from henbane (''Hyoscyamus niger''), mandrake ('' Mandragora officinarum'') and the sorcerers' tree ('' Latua pubiflora''). * Scopolamine, from henbane and ''Datura'' species (Jimson weed) All three acetylcholine-inhibiting chemicals can also be found in the leaves, stems, and flowers in varyi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Secondary Metabolite
Secondary metabolites, also called ''specialised metabolites'', ''secondary products'', or ''natural products'', are organic compounds produced by any lifeform, e.g. bacteria, archaea, fungi, animals, or plants, which are not directly involved in the normal cell growth, growth, Biological development, development, or reproduction of the organism. Instead, they generally mediate ecological biological interaction, interactions, which may produce a Natural selection, selective advantage for the organism by increasing its survivability or fecundity. Specific secondary metabolites are often restricted to a narrow set of species within a phylogenetic group. Secondary metabolites often play an important role in plant defense against herbivory and other interspecies defenses. Humans use secondary metabolites as medicines, flavourings, pigments, and recreational drugs. The term secondary metabolite was first coined by Albrecht Kossel, the 1910 Nobel Prize laureate for medicine and physio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solanaceae
Solanaceae (), commonly known as the nightshades, is a family of flowering plants in the order Solanales. It contains approximately 2,700 species, several of which are used as agricultural crops, medicinal plants, and ornamental plants. Many members of the family have high alkaloid contents, making some highly toxic, but many—such as tomatoes, potatoes, eggplants, and peppers—are commonly used in food. Originating in South America, Solanaceae now inhabits every continent on Earth except Antarctica. After the K—Pg extinction event they rapidly diversified and have adapted to live in deserts, tundras, rainforests, plains, and highlands, and taken on wide range of forms including trees, vines, shrubs, and epiphytes. Nearly 80% of all nightshades are included in the subfamily Solanoideae, most of which are members of the type genus ''Solanum''. Most taxonomists recognize six other subfamilies: Cestroideae, Goetzeoideae, Nicotianoideae, Petunioideae, Schizanthoideae, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hyoscyamus Niger
Henbane (''Hyoscyamus niger'', also black henbane and stinking nightshade) is a poisonous plant belonging to tribe Hyoscyameae of the nightshade family ''Solanaceae''. Henbane is native to temperate Europe and Siberia, and naturalised in Great Britain and Ireland. Historical use The name ''henbane'' dates from AD 1265; "bane" meant 'thing that causes death'. Other etymologies of ''henbane'' derive from the Indo-European stem ''bhelena'' meaning "crazy plant" and with the Proto-Germanic element ''bil'' meaning "vision", "hallucination", "magical power", and "miraculous ability". Historically, henbane was used in combination with other plants, such as the mandrake, the deadly nightshade, and datura, as an anaesthetic potion, and for its psychoactive properties in "magic brews". These psychoactive properties include visual hallucinations and a sensation of flight.Schultes & Smith 1976, p. 22 It was originally used in continental Europe, Asia, and the Arab world, though it did sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hyoscine
Scopolamine, also known as hyoscine, or Devil's Breath, is a medication used to treat motion sickness and postoperative nausea and vomiting. It is also sometimes used before surgery to decrease saliva. When used by injection, effects begin after about 20 minutes and last for up to 8 hours. It may also be used orally and as a transdermal patch since it has been long known to have transdermal bioavailability. Scopolamine is in the antimuscarinic family of drugs and works by blocking some of the effects of acetylcholine within the nervous system. Scopolamine was first written about in 1881 and started to be used for anesthesia around 1900. Scopolamine is also the main active component produced by certain plants of the nightshade family, which historically have been used as psychoactive drugs, known as ''deliriants'', due to their antimuscarinic-induced hallucinogenic effects in higher doses. In these contexts, its mind-altering effects have been utilized for recreat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Diabetes And Digestive And Kidney Diseases
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is part of the United States National Institutes of Health, which in turn is part of the Department of Health and Human Services. NIDDK is approximately the fifth-largest of the 27 List of institutes and centers of the National Institutes of Health, NIH institutes. The institute's mission is to support research, training, and communication with the public in the topic areas of "diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases". As of 2021, the Director of the institute is Griffin P. Rodgers, who assumed the position on an acting basis in 2006 and on a permanent basis in 2007. Mission The mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct and support medical research and research training and to disseminate science-based information on diabetes and ot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interstitial Cystitis
Interstitial cystitis (IC), a type of bladder pain syndrome (BPS), is chronic pain in the Urinary bladder, bladder and pelvic floor of unknown cause. Symptoms include urinary urgency, feeling the need to urinate right away, urinary frequency, needing to urinate often, bladder pain (pain in the organ) and pain with sex. IC/BPS is associated with depression (mood), depression and lower quality of life. Some of those affected also have irritable bowel syndrome and fibromyalgia. The cause of interstitial cystitis is unknown. While it can, it does not typically run in a family. The diagnosis is usually based on the symptoms diagnosis of exclusion, after ruling out other conditions. Typically the urine culture is negative. Ulceration or inflammation may be seen on cystoscopy. Other conditions which can produce similar symptoms include overactive bladder syndrome, overactive bladder, urinary tract infection (UTI), sexually transmitted infections, prostatitis, endometriosis in females ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal College Of Physicians
The Royal College of Physicians of London, commonly referred to simply as the Royal College of Physicians (RCP), is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1518, as the College of Physicians, the RCP is the oldest medical college in England. The RCP's home in Regent's Park is one of the few post-war buildings to be listed at Grade I. In 2016 it was announced that the RCP was to open new premises in Liverpool at The Spine, a new building in the Liverpool Knowledge Quarter. The Spine opened in May 2021. History The college was incorporated as "the President and College or Commonalty of the Faculty of Physic in London" when it received a royal charter in 1518, affirmed by Act of Parliament in 1523. It is not known when the name "Royal College of Physicians of London" was first assumed or granted. It came into use aft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Library Of Medicine
The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library. Located in Bethesda, Maryland, the NLM is an institute within the National Institutes of Health. Its collections include more than seven million books, journals, technical reports, manuscripts, microfilms, photographs, and images on medicine and related sciences, including some of the world's oldest and rarest works. the acting director of the NLM was Stephen Sherry. History The precursor of the National Library of Medicine, established in 1836, was the Library of the Surgeon General's Office, a part of the office of the Surgeon General of the United States Army. The Armed Forces Institute of Pathology and its Medical Museum were founded in 1862 as the Army Medical Museum. Throughout their history the Library of the Surgeon General's Office and the Army Medical Museum often shared quarters. From 1866 to 1887, they were ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drugs
A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via inhalation, injection, smoking, ingestion, absorption via a patch on the skin, suppository, or dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to treat, cure, prevent, or diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a regular basis for chronic disorders. Classification Pharmaceutical drugs are often classified into drug classes—groups of related drugs that hav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clap Mixture, Pharmacy Museum, New Orleans, LA
Clap may refer to: *Clapping, the percussive sound made by striking together two flat surfaces, as in the body parts of humans or animals *Gonorrhea, colloquially known as "the clap", a sexually transmitted infection caused by the bacterium ''Neisseria gonorrhoeae'' Music * "Clap" (Hostyle Gospel song), 2016 * "Clap" (Seventeen song), 2017 *"Clap", an instrumental by Yes from ''The Yes Album'' * "The Clap" (song), from ''High Risk Behaviour'' by the Chats People *Margaret Clap or Mother Clap (died ), keeper of a homosexual brothel in London, England *Thomas Clap or Thomas Clapp (1703–1767), president of Yale College Other uses *Clap skate, a type of ice skate used in speed skating * ''Clap'' (film), a 2022 Indian sports drama See also *CLAP (other) *Clap Clap (other) * Clapp, a surname * Clapper (other) *Thunderclap (other) Thunderclap may refer to: * Thunder, the sound caused by lightning. Arts and entertainment * Thunderclap (comics) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkinson's Disease
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become more prevalent as the disease progresses. The motor symptoms are collectively called parkinsonism and include tremors, bradykinesia, spasticity, rigidity as well as postural instability (i.e., difficulty maintaining balance). Non-motor symptoms develop later in the disease and include behavior change (individual), behavioral changes or mental disorder, neuropsychiatric problems such as sleep abnormalities, psychosis, anosmia, and mood swings. Most Parkinson's disease cases are idiopathic disease, idiopathic, though contributing factors have been identified. Pathophysiology involves progressive nerve cell death, degeneration of nerve cells in the substantia nigra, a midbrain region that provides dopamine to the basal ganglia, a system invo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
