Hla-dr7 Antigen

	Hla-dr7 Antigen HLA-DR7 (DR7) is a HLA- DR serotype that recognizes the DRB10701 to 0705 gene products. Serology The serological reaction of DR7 is excellent for 0701. The serology of 0703 to 0705 to 0709, and 0711 to 0714 serotypes is unknown. DRB10710N is a null allele. DRB10702 nomenclature has been deleted. Disease associations By serotype DR7 is positively associated with psoriasis vulgaris. By Allele group DRB107 is linked to ''T. cruzi'' infection with cardiomyopathy (also called Chaga's cardiomyopathy). By extended haplotype DR7:DQA10201:DQB10202 is associated with Graves' disease. DR7- DQ2/ DR5- DQ7 phenotype (transhaplotype encoded isoform DQα5β2) is the primary risk DQ isoform in celiac disease. DR7-DQ2/DR5-DQ7 (/ DR11-DQ7 or / DR12-DQ7) is a clarifying identifier for the at risk transhaplotype. DR53-DR7 may be associated with sclerosis/lupus associated anti-apolipoprotein antibodies. Genetic linkage HLA-DR7 is genetically linked HLA-DR53, and is linked to D ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	Anti-apolipoprotein Antibodies In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. As a result, AAHA are strongly implicated in autoimmune deep vein thrombosis. Also, it was proposed that AAHA is responsible for lupus anticoagulant. However, antiphospholipid antibodies bind phospholipids at sites similar to sites bound by anti-coagulants such as PAP1 sites and augment anti-coagulation activity. This contrasts with the major, specific, activity of AAHA, defining a subset of anti-cardiolipin antibodies Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome, idiopathi ... that specifically interacts ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Japan Japan is an island country in East Asia. Located in the Pacific Ocean off the northeast coast of the Asia, Asian mainland, it is bordered on the west by the Sea of Japan and extends from the Sea of Okhotsk in the north to the East China Sea in the south. The Japanese archipelago consists of four major islands—Hokkaido, Honshu, Shikoku, and Kyushu—and List of islands of Japan, thousands of smaller islands, covering . Japan has a population of over 123 million as of 2025, making it the List of countries and dependencies by population, eleventh-most populous country. The capital of Japan and List of cities in Japan, its largest city is Tokyo; the Greater Tokyo Area is the List of largest cities, largest metropolitan area in the world, with more than 37 million inhabitants as of 2024. Japan is divided into 47 Prefectures of Japan, administrative prefectures and List of regions of Japan, eight traditional regions. About three-quarters of Geography of Japan, the countr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Korea Korea is a peninsular region in East Asia consisting of the Korean Peninsula, Jeju Island, and smaller islands. Since the end of World War II in 1945, it has been politically Division of Korea, divided at or near the 38th parallel north, 38th parallel between North Korea (Democratic People's Republic of Korea; DPRK) and South Korea (Republic of Korea; ROK). Both countries proclaimed independence in 1948, and the two countries fought the Korean War from 1950 to 1953. The region is bordered by China to the north and Russia to the northeast, across the Yalu River, Amnok (Yalu) and Tumen River, Duman (Tumen) rivers, and is separated from Japan to the southeast by the Korea Strait. Known human habitation of the Korean peninsula dates to 40,000 BC. The kingdom of Gojoseon, which according to tradition was founded in 2333 BC, fell to the Han dynasty in 108 BC. It was followed by the Three Kingdoms of Korea, Three Kingdoms period, in which Korea was divided into Goguryeo, Baekje, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Antinode A node is a point along a standing wave where the wave has minimum amplitude. For instance, in a vibrating guitar string, the ends of the string are nodes. By changing the position of the end node through frets, the guitarist changes the effective length of the vibrating string and thereby the note played. The opposite of a node is an antinode, a point where the amplitude of the standing wave is at maximum. These occur midway between the nodes. Explanation Standing waves result when two sinusoidal wave trains of the same frequency are moving in opposite directions in the same space and interfere with each other. They occur when waves are reflected at a boundary, such as sound waves reflected from a wall or electromagnetic waves reflected from the end of a transmission line, and particularly when waves are confined in a resonator at resonance, bouncing back and forth between two boundaries, such as in an organ pipe or guitar string. In a standing wave the nodes are a se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Ireland Ireland (, ; ; Ulster Scots dialect, Ulster-Scots: ) is an island in the North Atlantic Ocean, in Northwestern Europe. Geopolitically, the island is divided between the Republic of Ireland (officially Names of the Irish state, named Irelanda sovereign state covering five-sixths of the island) and Northern Ireland (part of the United Kingdomcovering the remaining sixth). It is separated from Great Britain to its east by the North Channel (Great Britain and Ireland), North Channel, the Irish Sea, and St George's Channel. Ireland is the List of islands of the British Isles, second-largest island of the British Isles, the List of European islands by area, third-largest in Europe, and the List of islands by area, twentieth-largest in the world. As of 2022, the Irish population analysis, population of the entire island is just over 7 million, with 5.1 million in the Republic of Ireland and 1.9 million in Northern Ireland, ranking it the List of European islands by population, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Greenwich Greenwich ( , , ) is an List of areas of London, area in south-east London, England, within the Ceremonial counties of England, ceremonial county of Greater London, east-south-east of Charing Cross. Greenwich is notable for its maritime history and for giving its name to the Prime meridian (Greenwich), Greenwich Meridian (0° longitude) and Greenwich Mean Time. The town became the site of a royal palace, the Palace of Placentia, from the 15th century and was the birthplace of many House of Tudor, Tudors, including Henry VIII of England, Henry VIII and Elizabeth I. The palace fell into disrepair during the English Civil War and was demolished, eventually being replaced by the Greenwich Hospital (London), Royal Naval Hospital for Sailors, designed by Sir Christopher Wren and his assistant Nicholas Hawksmoor. These buildings became the Old Royal Naval College, Royal Naval College in 1873, and they remained a military education establishment until 1998, when they passed into the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Haplotype A haplotype (haploid genotype) is a group of alleles in an organism that are inherited together from a single parent. Many organisms contain genetic material (DNA) which is inherited from two parents. Normally these organisms have their DNA organized in two sets of pairwise similar chromosomes. The offspring gets one chromosome in each pair from each parent. A set of pairs of chromosomes is called diploid and a set of only one half of each pair is called haploid. The haploid genotype (haplotype) is a genotype that considers the singular chromosomes rather than the pairs of chromosomes. It can be all the chromosomes from one of the parents or a minor part of a chromosome, for example a sequence of 9000 base pairs or a small set of alleles. Specific contiguous parts of the chromosome are likely to be inherited together and not be split by chromosomal crossover, a phenomenon called genetic linkage. As a result, identifying these statistical associations and a few alleles of a specif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Serotype A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or Cell (biology), cells are classified together based on their shared reactivity between their surface antigens and a particular antiserum, allowing the classification of organisms to a Infraspecific name, level below the species. A group of serovars with common antigens is called a serogroup or sometimes ''serocomplex''. Serotyping often plays an essential role in determining species and subspecies. The ''Salmonella'' genus of bacteria, for example, has been determined to have over 2600 serotypes. ''Vibrio cholerae'', the species of bacteria that causes cholera, has over 200 serotypes, based on cell antigens. Only two of them have been observed to produce the potent enterotoxin that results in cholera: O1 and O139. Serotypes were discovered in hemolytic streptococci by the American microbiologist Rebecca Lancefield i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: class I, class II, and class III. In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. On the cell surface, these proteins are bound to protein fragments (peptides) that have been exported from within the cell. MHC class I proteins display these peptides to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-C HLA-C (Human Leukocyte Antigen-C) belongs to the MHC class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides. HLA-C is a locus on chromosome 6, which encodes for many HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA-C:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself. Disease associations By serotype Cw1: multinodular goiters By allele C16: B-cell chronic lymphocytic leukemia Nomenclature C01 Cw1 serotype: C01:02 and C01:09 Cw11 C01:04 to 01:08 C02 Cw2 serotype: C02:02 and 02:08 C02:03 to 02:07, and 02:09 C03 Cw9 serotype: C* ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	HLA-A HLA-A is a group of human leukocyte antigens (HLA) that are encoded by the ''HLA-A'' locus (genetics), locus, which is located at human chromosome 6p21.3. HLA is a major histocompatibility complex (MHC) antigen specific to humans. HLA-A is one of three major types of human MHC class I transmembrane proteins. The others are HLA-B and HLA-C. The protein is a heterodimer, and is composed of a heavy α chain and smaller β chain. The α chain is encoded by a variant #HLA-A gene, ''HLA-A'' gene, and the β chain (β2-microglobulin) is an invariant Beta-2 microglobulin, β2 microglobulin molecule. The β2 microglobulin protein is encoded by the ''B2M'' gene, which is located at chromosome 15q21.1 in humans. MHC Class I molecules such as HLA-A participate in a process that presents short polypeptides to the immune system. These polypeptides are typically 7–11 amino acids in length and originate from proteins being expressed by the cell. There are two classes of polypeptide that can be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]