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Gymnemic Acid
Gymnemic acids are a class of chemical compounds isolated from the leaves of ''Gymnema sylvestre'' (Apocynaceae). They are anti-sweet compounds, or sweetness inhibitors. After chewing the leaves, solutions sweetened with sugar taste like water. Chemically, gymnemic acids are triterpenoid glycosides. The central structure is the aglycone gymnemagenin (C30H50O6). This is adorned with a sugar such as glucuronic acid and with various ester groups. These variations give rise to the different gymnemic acids. More than 20 homologs of gymnemic acid are known. Gymnemic acid I has the highest anti-sweet properties. It suppresses the sweetness of most of the sweeteners including intense artificial sweeteners such as aspartame and natural sweeteners such as thaumatin, a sweet protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, inc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gymnema Sylvestre
''Gymnema sylvestre'' is a perennial woody vine native to Asia (including the Arabian Peninsula), Africa and Australia. It has been used in Ayurvedic medicine. Common names include gymnema, Australian cowplant, and Periploca of the woods, and the Hindi term ''gurmar'', which means "sugar destroyer". The leaves and extracts contain gymnemic acids, the major bioactive constituents that interact with taste receptors on the tongue to temporarily suppress the taste of sweetness. Description The plant is a climber with leaves having soft hairs on the upper surface. The leaves are elongated-oval in shape. It has a small, yellow, umbelliferous inflorescence that is produced throughout the year. Properties ''Gymnema sylvestre'' has a long history of use in herbal medicine and a broad range of therapeutic properties. Blocks sweet taste sensations Its leaves contain triterpenoid saponins, flavonols, and gurmarin. The major biologically active plant molecules are gymnemic acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetyl
In organic chemistry, an acetyl group is a functional group denoted by the chemical formula and the structure . It is sometimes represented by the symbol Ac (not to be confused with the element actinium). In IUPAC nomenclature, an acetyl group is called an ethanoyl group. An acetyl group contains a methyl group () that is single-bonded to a carbonyl (), making it an acyl group. The carbonyl center of an acyl radical has one non-bonded electron with which it forms a chemical bond to the remainder (denoted with the letter ''R'') of the molecule. The acetyl moiety is a component of many organic compounds, including acetic acid, the neurotransmitter acetylcholine, acetyl-CoA, acetylcysteine, acetaminophen (also known as paracetamol), and acetylsalicylic acid (also known as aspirin). Acetylation Acetylation is the chemical reaction known as "ethanoylation" in the IUPAC nomenclature. It depicts a reactionary process that injects an acetyl functional group into a chemical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gurmarin
Gurmarin is a 35-residue polypeptide from the Asclepiad vine ''Gymnema sylvestre'' (Gurmar). It has been utilized as a pharmacological Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between ... tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet taste in rats. This rat inhibition appears to have high specificity to sugar (sweetener) molecules like sucrose, glucose, and saccharin as well as the amino acid glycine. As a sweet-taste-suppressing protein, Gurmarin shows signs of being reversible in nature although having little to no effect on the sweet taste sensation in humans suggesting the protein is only active on rodent sweet taste receptors. Structure and inhibitory effect Gurmarin is a peptide used to eliminate swee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ziziphin
Ziziphin, a triterpene glycoside which exhibits taste-modifying properties, has been isolated from the leaves of ''Ziziphus jujuba'' (''Rhamnaceae''). Among ziziphin's known homologues found in this plant, it is the most anti-sweet. However, its anti-sweet activity is less effective than gymnemic acid 1, another anti-sweet compound glycoside isolated from the leaves of ''Gymnema sylvestre'' (Asclepiadaceae).Kinghorn, A.D. and Compadre, C.M. ''Alternative Sweeteners: Third Edition, Revised and Expanded'', Marcel Dekker ed., New York, 2001. Ziziphin reduces perceived sweetness of most of the carbohydrates (e.g. glucose, fructose), bulk sweeteners, intense sweeteners (natural: steviol glycoside – artificial: sodium saccharin and aspartame) and sweet amino acids (e.g. glycine Glycine (symbol Gly or G; ) is an amino acid that has a single hydrogen atom as its side chain. It is the simplest stable amino acid. Glycine is one of the proteinogenic amino acids. It is enco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactisole
Lactisole is the sodium salt and commonly supplied form of 2-(4-methoxy phenoxy)propionic acid, a natural carboxylic acid found in roasted coffee beans. Like gymnemic acid, it has the property of masking sweet flavors and is used for this purpose in the food industry. Chemistry Chemically, lactisole is a double ether of hydroquinone. Since it contains an asymmetric carbon atom the molecule is chiral, with the S enantiomer predominating in natural sources and being primarily responsible for the sweetness-masking effect. Commercial lactisole is a racemic mixture of the R and S forms.T. Nakagita et al "Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor" PLoS One. 2019; 14(3): e0213552 Natural occurrences The parent acid of lactisole was discovered in 1989 in roasted Colombian arabica coffee beans in a concentration of 0.5 to 1.2 ppm. Anti-sweet properties At concentrations of 100–150 par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hodulcine
Hodulcine (or hoduloside) are glycosides (dammarane-type triterpenes) which are isolated from the leaves of ''Hovenia dulcis Thunb.'' (''Rhamnaceae'') also known as Japanese Raisin Tree. Several glycosides homologue have been found in this plant and although hoduloside 1 exhibits the highest anti-sweet activity, it is less potent than gymnemic acid 1.Kinghorn, A.D. and Compadre, C.M. Alternative Sweeteners: Third Edition, Revised and Expanded, Marcel Dekker ed., New York, 2001. See also * Gymnemic acid * Lactisole * Ziziphin Ziziphin, a triterpene glycoside which exhibits taste-modifying properties, has been isolated from the leaves of ''Ziziphus jujuba'' (''Rhamnaceae''). Among ziziphin's known homologues found in this plant, it is the most anti-sweet. However, its ... References External links Hovenia dulcis - Plants For A Future database report Taste modifiers Triterpene glycosides {{Carbohydrate-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mole (unit)
The mole (symbol mol) is a unit of measurement, the base unit in the International System of Units (SI) for ''amount of substance'', an SI base quantity proportional to the number of elementary entities of a substance. One mole is an aggregate of exactly elementary entities (approximately 602 sextillion or 602 billion times a trillion), which can be atoms, molecules, ions, ion pairs, or other particles. The number of particles in a mole is the Avogadro number (symbol ) and the numerical value of the '' Avogadro constant'' (symbol ) expressed in mol−1. The relationship between the mole, Avogadro number, and Avogadro constant can be expressed in the following equation:1\text = \frac = \frac The current SI value of the mole is based on the historical definition of the mole as the amount of substance that corresponds to the number of atoms in 12 grams of 12C, which made the molar mass of a compound in grams per mole, numerically equal to the average molecular mass or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molar Mass
In chemistry, the molar mass () (sometimes called molecular weight or formula weight, but see related quantities for usage) of a chemical substance ( element or compound) is defined as the ratio between the mass () and the amount of substance (, measured in moles) of any sample of the substance: . The molar mass is a bulk, not molecular, property of a substance. The molar mass is a ''weighted'' ''average'' of many instances of the element or compound, which often vary in mass due to the presence of isotopes. Most commonly, the molar mass is computed from the standard atomic weights and is thus a terrestrial average and a function of the relative abundance of the isotopes of the constituent atoms on Earth. The molecular mass (for molecular compounds) and formula mass (for non-molecular compounds, such as ionic salts) are commonly used as synonyms of molar mass, as the numerical values are identical (for all practical purposes), differing only in units ( dalton vs. g/mol o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Formula
A chemical formula is a way of presenting information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, such as parentheses, dashes, brackets, commas and ''plus'' (+) and ''minus'' (−) signs. These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a chemical name since it does not contain any words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulae can fully specify the structure of only the simplest of molecules and chemical substances, and are generally more limited in power than chemical names and structural formulae. The simplest types of chemical formulae are called '' empirical formulae'', which use letters and numbers indicating the numerical ''proportions'' of atoms ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PubChem
PubChem is a database of Chemistry, chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine, which is part of the United States National Institutes of Health (NIH). PubChem can be accessed for free through a web user interface. Millions of compound structures and descriptive datasets can be freely downloaded via FTP. PubChem contains multiple substance descriptions and small molecules with fewer than 100 atoms and 1,000 bonds. More than 80 database vendors contribute to the growing PubChem database. History PubChem was released in 2004 as a component of the Molecular Libraries Program (MLP) of the NIH. As of November 2015, PubChem contains more than 150 million depositor-provided substance descriptions, 60 million unique chemical structures, and 225 million biological activity test results (from over 1 million assay experiments performe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrogen
Hydrogen is a chemical element; it has chemical symbol, symbol H and atomic number 1. It is the lightest and abundance of the chemical elements, most abundant chemical element in the universe, constituting about 75% of all baryon, normal matter. Under standard conditions, hydrogen is a gas of diatomic molecules with the chemical formula, formula , called dihydrogen, or sometimes hydrogen gas, molecular hydrogen, or simply hydrogen. Dihydrogen is colorless, odorless, non-toxic, and highly combustible. Stars, including the Sun, mainly consist of hydrogen in a plasma state, while on Earth, hydrogen is found as the gas (dihydrogen) and in molecular forms, such as in water and organic compounds. The most common isotope of hydrogen (H) consists of one proton, one electron, and no neutrons. Hydrogen gas was first produced artificially in the 17th century by the reaction of acids with metals. Henry Cavendish, in 1766–1781, identified hydrogen gas as a distinct substance and discovere ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
