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Frizzled
Frizzled is a family of atypical G protein-coupled receptor, G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Species distribution Frizzled proteins and the genes that encode them have been identified in an array of animals, from sponges to humans. Function Frizzled proteins also play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. These processes occur as a result of one of three signaling pathways. These include the canonical Wnt_signaling_pathway#Canonical_pathway, Wnt/β-catenin pathway, Wnt signaling pathway#Noncanonical pathways, Wnt/calcium pathway, and Wnt_signaling_pathway#Noncanonical_pathways, planar cell polarity (PCP) pathway. Mutations in the human frizzled-4 receptor have been linked to familial exudativ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD1
Frizzled-1 (Fz-1) is a protein that in humans is encoded by the ''FZD1'' gene. Function Members of the 'frizzled' gene family encode G protein–coupled receptor, 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. References Further reading * * * * * * * * External links * G protein-coupled receptors {{transmembranereceptor-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD4
Frizzled-4 (Fz-4) is a protein that in humans is encoded by the ''FZD4'' gene. Fz-4 has also been designated as CD344 (cluster of differentiation 344). Function This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Frizzled-4 is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins. FZD4 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD2
Frizzled-2 (Fz-2) is a protein that in humans is encoded by the ''FZD2'' gene. Members of the 'frizzled Frizzled is a family of atypical G protein-coupled receptor, G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol ...' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the ''FZD2'' gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary. References Further reading * * * * * * * * External links * G protein-coupled receptors {{transmembranereceptor-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD6
Frizzled-6 (Fz-6) is a protein that in humans is encoded by the ''FZD6'' gene. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Fz-6 is believed to be the receptor for the WNT4 ligand. Interactions Fz-6 has been shown to interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ... with secreted frizzled-related protein 1. References Further reading * * * * * * External links * {{G protein-coupled receptors, g4 G protein-coupled receptors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD3
Frizzled-3 (Fz-3) is a protein that in humans is encoded by the ''FZD3'' gene. Function This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development. The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells. See also * Frizzled Frizzled is a family of atypical G protein-coupled receptor, G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD7
Frizzled-7 (Fd-7) is a protein that in humans is encoded by the ''FZD7'' gene. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. Interactions Fz-7 has been shown to interact with DLG4 PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the ''DLG4'' (discs large homolog 4) gene. PSD-95 is a member of the membrane-associated guanylate kinase (MA .... References Further reading * * * * * * * * * * * External links * G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD9
Frizzled-9 (Fz-9) is a protein that in humans is encoded by the ''FZD9'' gene. Fz-9 has also been designated as CD349 (cluster of differentiation 349). Function Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7 Chromosome 7 is one of the 23 pairs of chromosomes in humans, who normally have two copies of this chromosome. Chromosome 7 spans about 160 million base pairs (the building material of DNA) and represents between 5 and 5.5 percent of the total DN ..., and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. References Further reading * * * * * * * * External links * * {{G protein-coupled receptors, g4 Clusters of differentiation G protein-coupled receptors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD5
Frizzled-5 (Fz-5) is a protein that in humans is encoded by the ''FZD5'' gene. Members of the 'frizzled Frizzled is a family of atypical G protein-coupled receptor, G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol ...' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Fz-5 is believed to be the receptor for the Wnt5A ligand. References Further reading * * * * * * * * * * * * * * External links * G protein-coupled receptors {{transmembranereceptor-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD8
Frizzled-8 (Fz-8) is a protein that in humans is encoded by the ''FZD8'' gene. Function This intronless gene is a member of the frizzled Frizzled is a family of atypical G protein-coupled receptor, G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol ... gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. References Further reading * * * * * * * * * External links * * G protein-coupled receptors< ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FZD10
Frizzled-10 (Fz-10) is a protein that in humans is encoded by the ''FZD10'' gene. Fz-10 has also been designated as CD350 (cluster of differentiation 350). Function This gene is a member of the frizzled Frizzled is a family of atypical G protein-coupled receptor, G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol ... gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. References Further reading * * * * * External links * * Clusters of differentiation G protein-coupled receptors {{transmembran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vantictumab
Vantictumab is a human IgG2 monoclonal antibody designed for the treatment of cancer. This drug was developed by OncoMed Pharmaceuticals Inc. in partnership with Bayer. OncoMed was awarded a patent in 2016, which is set to expire in 2029. In April 2017, Bayer terminated its option to license vantictumab. It inhibits wnt signalling by targeting the frizzled receptors on cancer cells. Phase I trials have been completed for pancreatic cancer, non-small cell lung cancer, and breast cancer. In 2016 results were reported from a phase 1b clinical trial for triple-negative breast cancer Triple-negative breast cancer (TNBC) is any breast cancer that either lacks or shows low levels of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) overexpression and/or gene amplification (i.e ... and in 2020 for pancreatic cancer. References Monoclonal antibodies for tumors Experimental cancer drugs {{monoclonal-antibody-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wnt Signaling Pathway
In cellular biology, the Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt, pronounced "wint", is a portmanteau created from the names Wingless and Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, and is thought to be negatively regulated in part ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
