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Fluvalinate
Fluvalinate is a synthetic pyrethroid chemical compound contained as an active agent in the products Apistan, Klartan, and Minadox, that is an acaricide (specifically, a miticide), commonly used to control varroa mites, ''Varroa'' mites in honey bee colonies, infestations that constitute a significant Diseases of the honeybee, disease of such insects. Fluvalinate is a stable, nonvolatile, viscous, heavy oil (technical) soluble in organic solvents. Although the compound may be found in Drone (bee), drones, a study has found honey samples virtually absent of fluvalinate, on account of its affinity to beeswax. CHS Health Classification Fluvalinate is considered an acute toxic, Health hazard and environmental hazard by ECHA (European Chemicals Agency). The chemical is fatal if inhaled and is extremally toxic to aquatic life. If not fatal the effects are permanent and has multiple long lasting effects. Stereoisomerism Fluvalinate is synthesized from Racemate, racemic valine [( ...
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Varroa Mites
''Varroa destructor'', the Varroa mite, is an ectoparasite, external parasitic mite that attacks and feeds on honey bees and is one of the most damaging honey bee pests in the world. A significant mite infestation leads to the death of a honey bee colony, usually in the late autumn through early spring. Without management for Varroa mite, honey bee colonies typically collapse within 2 to 3 years in temperate climates. These mites can infest ''Apis mellifera'', the western honey bee, and ''Apis cerana'', the Asian honey bee. Due to very similar physical characteristics, this species was thought to be the closely related ''Varroa jacobsoni'' prior to 2000, but they were found to be two separate species after DNA analysis. Parasitism of bees by mites in the genus ''Varroa'' is called varroosis. The Varroa mite can reproduce only in a honey bee colony. It attaches to the body of the bee and weakens the bee. The species is a vector for at least five debilitating bee viruses, includin ...
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Diseases Of The Honeybee
Diseases of the honey bee or abnormal hive conditions include: Pests and parasites ''Varroa'' mites ''Varroa destructor'' and ''V. jacobsoni'' are parasitic mites that feed on the fat bodies of adult, pupal and larval bees. When the hive is very heavily infested, ''Varroa'' mites can be seen with the naked eye as a small red or brown spot on the bee's thorax. ''Varroa'' mites are carriers for many viruses that are damaging to bees. For example, bees infected during their development will often have visibly deformed wings. ''Varroa'' mites have led to the virtual elimination of feral bee colonies in many areas, and are a major problem for kept bees in apiaries. Some feral populations are now recovering—it appears they have been naturally selected for ''Varroa'' resistance. ''Varroa'' mites were first discovered in Southeast Asia in about 1904, but are now present on all continents, following their introduction to Australia in 2022. They were discovered in the United S ...
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Diseases Of The Honey Bee
Diseases of the honey bee or abnormal hive conditions include: Pests and parasites ''Varroa'' mites ''Varroa destructor'' and ''V. jacobsoni'' are parasite, parasitic mites that feed on the fat bodies of adult, pupal and larval bees. When the hive is very heavily infested, ''Varroa'' mites can be seen with the naked eye as a small red or brown spot on the bee's thorax. ''Varroa'' mites are carriers for many viruses that are damaging to bees. For example, bees infected during their development will often have visibly Deformed Wing Virus, deformed wings. ''Varroa'' mites have led to the virtual elimination of feral bee colonies in many areas, and are a major problem for kept bees in apiary, apiaries. Some feral populations are now recovering—it appears they have been natural selection, naturally selected for ''Varroa'' resistance. ''Varroa'' mites were first discovered in Southeast Asia in about 1904, but are now present on all continents, following their introduction to ...
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Pyrethroid
A pyrethroid is an organic compound similar to the natural pyrethrins, which are produced by the flowers of pyrethrums (''Chrysanthemum cinerariaefolium'' and ''Chrysanthemum coccineum, C. coccineum''). Pyrethroids are used as commercial and household insecticides. In household concentrations pyrethroids are generally harmless to humans. However, pyrethroids are toxic to insects such as bees, dragonflies, mayflies, Horse-fly, gadflies, and some other invertebrates, including those that constitute the base of aquatic and terrestrial food webs. Pyrethroids are toxic to aquatic organisms, especially fish.Pyrethroids fact sheet
from the Illinois Department of Public Health.
They have been shown to be an effective control measure for malaria outbreaks, through indoor applications.


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Absolute Configuration
In chemistry, absolute configuration refers to the spatial arrangement of atoms within a molecular entity (or Functional group, group) that is chirality (chemistry), chiral, and its resultant stereochemical description. Absolute configuration is typically relevant in organic molecules where carbon is bonded to four different substituents. This type of construction creates two possible enantiomers. Absolute configuration uses a set of rules to describe the relative positions of each bond around the chiral center atom. The most common labeling method uses the descriptors ''R'' or ''S'' and is based on the Cahn–Ingold–Prelog priority rules. ''R'' and ''S'' refer to and , Latin for right and left, respectively. Chiral molecules can differ in their chemical properties, but are identical in their physical properties, which can make distinguishing enantiomers challenging. Absolute configurations for a chiral molecule (in pure form) are most often obtained by X-ray crystallography, ...
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Nitriles
In organic chemistry, a nitrile is any organic compound that has a functional group. The name of the compound is composed of a base, which includes the carbon of the , suffixed with "nitrile", so for example is called "propionitrile" (or propanenitrile). The prefix ''cyano-'' is used interchangeably with the term ''nitrile'' in industrial literature. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex, latex-free laboratory and medical gloves. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. Inorganic compounds containing the group are not called nitriles, but cyanides instead. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Structure and basic properties The N−C−C geome ...
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Trifluoromethyl Compounds
The trifluoromethyl group is a functional group that has the formula In science, a formula is a concise way of expressing information symbolically, as in a mathematical formula or a ''chemical formula''. The informal use of the term ''formula'' in science refers to the general construct of a relationship betwe ... . The naming of is group is derived from the methyl group (which has the formula ), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane , 1,1,1-trifluoroethane , and hexafluoroacetone . Compounds with this group are a subclass of the organofluorines. Properties The trifluoromethyl group has a significant electronegativity that is often described as being intermediate between the electronegativities of fluorine and chlorine. For this reason, trifluoromethyl-substituted compounds are often strong acids, such as trifluoromethanesulfonic acid and trifluoroacetic acid. Conversely, the trifluoromethyl group lowers the basicity of ...
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Chloroarenes
In organic chemistry, an aryl halide (also known as a haloarene) is an aromatic compound in which one or more hydrogen atoms directly bonded to an aromatic ring are replaced by a halide ion (such as fluorine F''−'', chlorine Cl−1,−3,−5, bromine Br−1, or iodine I−). Aryl halides are distinct from haloalkanes (alkyl halides) due to significant differences in their methods of preparation, chemical reactivity, and physical properties. The most common and important members of this class are aryl chlorides, but the group encompasses a wide range of derivatives with diverse applications in organic synthesis, pharmaceuticals, and materials science. Classification according to halide Aryl fluorides Aryl fluorides are used as synthetic intermediates, e.g. for the preparation of pharmaceuticals, pesticides, and liquid crystals. The conversion of diazonium salts is a well established route to aryl fluorides. Thus, anilines are precursors to aryl fluorides. In the classic Schiemann ...
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Pyrethroids
A pyrethroid is an organic compound similar to the natural pyrethrins, which are produced by the flowers of pyrethrums (''Chrysanthemum cinerariaefolium'' and '' C. coccineum''). Pyrethroids are used as commercial and household insecticides. In household concentrations pyrethroids are generally harmless to humans. However, pyrethroids are toxic to insects such as bees, dragonflies, mayflies, gadflies, and some other invertebrates, including those that constitute the base of aquatic and terrestrial food webs. Pyrethroids are toxic to aquatic organisms, especially fish.Pyrethroids fact sheet
from the Illinois Department of Public Health.
They have been shown to be an effective control measure for malaria outbreaks, through indoor applications.


Mode of action

Pyrethr ...
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Pyrethroid
A pyrethroid is an organic compound similar to the natural pyrethrins, which are produced by the flowers of pyrethrums (''Chrysanthemum cinerariaefolium'' and ''Chrysanthemum coccineum, C. coccineum''). Pyrethroids are used as commercial and household insecticides. In household concentrations pyrethroids are generally harmless to humans. However, pyrethroids are toxic to insects such as bees, dragonflies, mayflies, Horse-fly, gadflies, and some other invertebrates, including those that constitute the base of aquatic and terrestrial food webs. Pyrethroids are toxic to aquatic organisms, especially fish.Pyrethroids fact sheet
from the Illinois Department of Public Health.
They have been shown to be an effective control measure for malaria outbreaks, through indoor applications.


...
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Acaricide
Acaricides are pesticides that kill members of the arachnid subclass '' Acari'', which includes ticks and mites. Acaricides are used both in medicine and agriculture, although the desired selective toxicity differs between the two fields. Terminology More specific words are sometimes used, depending upon the targeted group: * "Ixodicides" are substances that kill ticks. * "Miticides" are substances that kill mites. *The term scabicide is more narrow, and refers to agents specifically targeting '' Sarcoptes''. *The term "arachnicide" is more general, and refers to agents that target arachnids. This term is used much more rarely, but occasionally appears in informal writing. As a practical matter, mites are a paraphyletic grouping, and mites and ticks are usually treated as a single group. Examples Examples include: * Permethrin can be applied as a spray. The effects are not limited to mites: lice, cockroaches, fleas, mosquitos, and other insects will be affected. * Ivermec ...
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