|
Farinomalein
Farinomalein is a natural maleimide with formula C10H13NO4 - was first isolated from the entomopathogenic fungus ''Isaria farinosa'' (''Paecilomyces farinosus'') - source H599 (Japan). Farinomalein has shown potent and selective inhibition (0.15-5 μg/disk) against eight isolates of plant pathogenic ''Phytophthora sojae''.Sastia Prama Putri, Hiroshi Kinoshita, Masayasu Kato and Takuya Nihira. ''Antimicrobial and antioomycete activities of the novel antibiotic farinomalein''. Poster Presentation 2P-2124, Annual Conference, The Society for Bioscience and Bioengineering, Japan, 28 October 2010. These results suggest that farinomalein might be useful as a candidate pesticide for the treatment of Phytophthora stem rot in soybean. Synthesis A simple two-stage synthesis from the γ-hydroxybutenolide compound, 5-hydroxy-4-methyl-2-5(''H'')-furanone, has been reported. Firstly, the furanone is oxidized to 3-isopropylfuran-2,5-dione by Dess–Martin periodinane Dess–Martin periodina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maleimide
Maleimide is a chemical compound with the formula H2C2(CO)2NH (see diagram). This unsaturated imide is an important building block in organic synthesis. The name is a contraction of maleic acid and imide, the -C(O)NHC(O)- functional group. Maleimides are also a ''class'' of derivatives of the parent maleimide where the N''H'' group is replaced with alkyl or aryl groups such as a methyl or phenyl, respectively. The substituent can also be a small molecule (such as biotin, a fluorescent dye, an oligosaccharide, or a nucleic acid), a reactive group, or a synthetic polymer such as polyethylene glycol. Human hemoglobin chemically modified with maleimide-polyethylene glycol is a blood substitute called MP4. Reactions Many analogues of maleimide are prepared by treating maleic anhydride with amines followed by dehydration. A defining feature of the reactivity of maleimides is their susceptibility to additions across the double bond either by Michael additions or via Diels-Alder react ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maleimides
Maleimide is a chemical compound with the chemical formula, formula H2C2(CO)2NH (see diagram). This unsaturated imide is an important building block in organic synthesis. The name is a contraction of maleic acid and imide, the -C(O)NHC(O)- functional group. Maleimides are also a ''class'' of derivatives of the parent maleimide where the N''H'' group is replaced with alkyl or aryl groups such as a methyl or phenyl, respectively. The substituent can also be a small molecule (such as biotin, a fluorescent dye, an oligosaccharide, or a nucleic acid), a reactive group, or a synthetic polymer such as polyethylene glycol. Human hemoglobin chemically modified with maleimide-polyethylene glycol is a blood substitute called MP4. Reactions Many analogues of maleimide are prepared by treating maleic anhydride with amines followed by dehydration. A defining feature of the reactivity of maleimides is their susceptibility to additions across the double bond either by Michael additions or via D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phytophthora Sojae
''Phytophthora sojae'' is an oomycete and a soil-borne plant pathogen that causes stem and root rot of soybean. This is a prevalent disease in most soybean growing regions, and a major cause of crop loss. In wet conditions the pathogen produces zoospores that move in water and are attracted to soybean roots. Zoospores can attach to roots, germinate, and infect the plant tissues. Diseased roots develop lesions that may spread up the stem and eventually kill the entire plant. ''Phytophthora sojae'' also produces oospores that can remain dormant in the soil over the winter, or longer, and germinate when conditions are favourable. Oospores may also be spread by animals or machinery. ''Phytophthora sojae'' is a diploid organism with a genome size of 95 Mbp (Millions of base pairs). The natural chemical farinomalein (a metabolite from entomopathogenic fungus '' Paecilomyces farinosus''Sastia P. Putri, Hiroshi Kinoshita, Fumio Ihara, Yasuhiro Igarashi and Takuya Nihira. ''Farinoma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Entomopathogenic Fungus
Entomopathogenic fungi are parasitic unicellular or multicellular microorganisms belonging to the kingdom of Fungi, that can infect and seriously disable or kill insects. Pathogenicity for insects is widely distributed in the kingdom of fungi and occur in six fungal phyla (Ascomycota, Oomycetes, Basidiomycota, Chytridiomycota, Zygomycota, and Microsporidia). It plays a vital ecological role in controlling insect populations by impacting 19 out of 30 known insect orders. Some fungal entomopathogens are opportunistic whereas some have evolved into highly specific pathogens of insects. Mode of infection Unlike many other insect pathogens (entomopathogenic viruses, nematodes, or bacteria), most entomopathogenic fungi do not require entry through ingestion or oral intake and instead directly attack the insect cuticle and penetrate the insect body through the exoskeleton. These fungi use a broad spectrum of virulence factors such as adhesins (to attach to insect cuticles), lytic enzym ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isaria Farinosa
''Cordyceps'' is a genus of ascomycete fungi (sac fungi) that includes over 260 species worldwide, many of which are parasitic. Diverse variants of cordyceps have had more than 1,500 years of use in Chinese medicine. Most ''Cordyceps'' species are Parasitoid#Types of parasitoids, endoparasitoids, parasitic mainly on insects and other arthropods (they are thus entomopathogenic fungi); a few are parasitic on other fungi. The generic name ''Cordyceps'' is derived from the ancient Greek κορδύλη ''kordýlē'', meaning "club", and the Latin language, Latin ''-ceps'', derived from Latin ''caput'', meaning "head". The genus has a worldwide distribution, with most of the known species being from Asia. Taxonomy There are two recognized subgenera: *''Cordyceps'' subgen. ''Cordyceps'' Fr. 1818 *''Cordyceps'' subgen. ''Cordylia'' Edmond Tulasne, Tul. & Charles Tulasne, C. Tul. 1865 ''Cordyceps'' sensu stricto are the teleomorphs of several genera of Teleomorph, anamorph and holo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phytophthora
''Phytophthora'' (from Greek (''phytón''), "plant" and (), "destruction"; "the plant-destroyer") is a genus of plant-damaging oomycetes (water molds), whose member species cause economic losses on crops worldwide, as well as environmental damage in natural ecosystems. The cell wall of ''Phytophthora'' is made up of cellulose. The genus was first described by Heinrich Anton de Bary in 1875. Approximately 210 species have been described, although 100–500 undiscovered ''Phytophthora'' species are estimated to exist. Pathogenicity ''Phytophthora'' spp. are mostly pathogens of dicotyledons, and many are relatively host-specific parasites. '' P. cinnamomi'', though, infects thousands of species ranging from club mosses, ferns, cycads, conifers, grasses, lilies, to members of many dicotyledonous families. Many species of ''Phytophthora'' are plant pathogens of considerable economic importance. '' P. infestans'' was the infective agent of the potato blight that caused the Gr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dess–Martin Periodinane
Dess–Martin periodinane (DMP) is a chemical reagent used in the Dess–Martin oxidation, Alcohol oxidation, oxidizing primary alcohols to aldehydes and secondary Alcohol (chemistry), alcohols to ketones. This periodinane has several advantages over chromium- and dimethyl sulfoxide, DMSO-based oxidants that include milder conditions (room temperature, neutral pH), shorter reaction times, higher yields, simplified workups, high chemoselectivity, tolerance of sensitive functional groups, and a long shelf life. However, use on an industrial scale is made difficult by its cost and its potentially explosive nature. It is named after the American chemists Daniel Benjamin Dess and James Cullen Martin who developed the reagent in 1983. It is based on 2-Iodoxybenzoic acid, IBX, but due to the acetate groups attached to the central iodine atom, DMP is much more reactive than IBX and is much more soluble in organic solvents. : Preparation The most friendly synthesis of IBX has been determin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carboxylic Acids
In organic chemistry, a carboxylic acid is an organic acid that contains a carboxyl group () attached to an Substituent, R-group. The general formula of a carboxylic acid is often written as or , sometimes as with R referring to an organyl group (e.g., alkyl, alkenyl, aryl), or hydrogen, or other groups. Carboxylic acids occur widely. Important examples include the amino acids and fatty acids. Deprotonation of a carboxylic acid gives a carboxylate anion. Examples and nomenclature Carboxylic acids are commonly identified by their trivial names. They often have the suffix ''-ic acid''. IUPAC-recommended names also exist; in this system, carboxylic acids have an ''-oic acid'' suffix. For example, butyric acid () is butanoic acid by IUPAC guidelines. For nomenclature of complex molecules containing a carboxylic acid, the carboxyl can be considered position one of the parent chain even if there are other substituents, such as 3-chloropropanoic acid. Alternately, it can be named ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pesticides
Pesticides are substances that are used to pest control, control pest (organism), pests. They include herbicides, insecticides, nematicides, fungicides, and many others (see table). The most common of these are herbicides, which account for approximately 50% of all pesticide use globally. Most pesticides are used as plant protection products (also known as crop protection products), which in general protect plants from weeds, fungi, or insects. In general, a pesticide is a Chemical substance, chemical or biological agent (such as a virus, bacterium, or entomopathogenic fungus, fungus) that deters, incapacitates, kills, or otherwise discourages pests. Target pests can include insects, plant pathogens, weeds, mollusca, molluscs, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, cause nuisance, spread disease, or are disease Vector (epidemiology), vectors. Along with these benefits, pesticides also have drawbacks, such as Pesticide poisoning, potent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
